Actikerall

The usual adult dose of fluorouracil - salicylic acid is 1 application of the solution to the lesions, once daily. Several lesions may be treated at a time, but the area being treated should not be larger than 25 cm² (5 cm × 5 cm). A total of 10 lesions may be treated at a time.

Fluorouracil - salicylic acid should only come into contact with the lesion and a very small area of healthy skin surrounding the lesion.

Clean the affected area with warm water and wait until the skin has completely dried before applying the solution.

Actikerall comes in a bottle with a brush applicator attached to the cap. Wipe the brush on the neck of the bottle before applying it to the affected area. After applying the solution to the lesion, let the solution dry on the skin, uncovered. A white film will form over the affected area. This improves the absorption of the medication into the lesion and protects the lesion from dirt and debris. Do not cover the treatment area with any type of dressing. Before applying the next dose, peel the film off the lesion to expose it to the next dose of medication. Warm water may also help remove the film.

Do not allow Actikerall to come in contact with the eyes, the inside of the nose or mouth, or the genitals. Close the lid of the bottle tightly after using to prevent it from drying out. Do not use Actikerall if it dries out or forms any crystals.

Actikerall usually starts to work within 6 weeks. Continue to use the medication for up to 12 weeks or until the lesions have completely cleared up. It may take up to 8 weeks after stopping the medication for the lesions to completely heal.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to use Actikerall exactly as prescribed by your doctor.

If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Actikerall at room temperature, protect it from light and moisture, and keep it out of the reach of children. Actikerall is flammable. Keep it away from fire or flames. If there is any medication left in the bottle 3 months after opening it, safely discard the remaining medication.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

In addition to its desired action, this medication may cause some adverse effects, notably: it may cause local pain; it may cause inflammation at the site where the medication is used; it may make your skin more sensitive to UV rays (e.g., sunlight, tanning lamps) - avoid exposure to UV rays as much as possible and protect yourself when out in the sun; it may cause local irritation. Each person may react differently to a treatment. If you think this medication may be causing adverse effects (including those described here, or others), talk to your health care professional. He or she can help you to determine whether or not the medication is the source of the problem.

Each 1 mL of clear, colourless to slightly orange-white solution contains 0.5% fluorouracil and 10% salicylic acid. Nonmedicinal ingredients: dimethyl sulfoxide, ethanol, ethyl acetate, pyroxyline, poly(butyl metacrylate, methyl methacrylate).

Do not take Actikerall if you:

• are allergic to fluorouracil, salicylic acid, or any ingredients of the medication
• are allergic to Capecitabine
• are allergic to salicylates
• have reduced kidney function
• are pregnant
• are breast-feeding
• have a condition known as dihydropyrimidine dehydrogenase (DPD) deficiency
• are taking medications that interfere with DPD

There may be an interaction between fluorouracil - salicylic acid and any of the following:

• benzoyl peroxide
• capecitabine
• Gemcitabine
• Isotretinoin
• Leucovorin Calcium
• Methotrexate
• other skin products that cause irritation or drying (e.g., cleansers, alcohol-containing cosmetics)
• Phenytoin
• Sorafenib
• sulfonylureas (e.g., Glyburide, Gliclazide)
• tretinoin
• Warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Actikerall. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Actikerall.

Diabetes: If you have diabetes, you may not notice severe reactions to Actikerall, particularly if you are applying Actikerall to an area of skin that you cannot see. Your doctor should closely monitor the progress of your treatment to avoid severe skin reactions.

Skin sensitivity: The area that is treated with Actikerall will be more sensitive to exposure to the sun. An exaggerated Sunburn reaction may occur. Avoid exposure to excessive sunlight, including sunlamps and tanning beds, and use sunblock with minimum SPF 15. It is normal to experience some redness and irritation in the areas where Actikerall has been applied.

Staining: This solution may cause permanent staining to clothing, fabric, or acrylics, such a bathubs. Avoid contact with these until the solution has dried.

Pregnancy: Although Actikerall is applied to the skin and is not expected to be absorbed into the body, other forms of fluorouracil cause harm to the developing baby when used during pregnancy. To avoid exposing the developing baby to Actikerall, it should not be used during pregnancy. If you become pregnant while taking Actikerall, contact your doctor immediately.

Breast-feeding: It is not known if fluorouracil - salicylic acid passes into breast milk. If you are a breast-feeding mother and are taking Actikerall, it may affect your baby. Breast-feeding is not recommended while using Actikerall.

Children: The safety and effectiveness of using Actikerall have not been established for children.

This medication is to be applied on the skin. To use: Clean the affected area. Apply small amount of the product and limit the application to the affected area. Wash your hands after applying the medication. Do not let this product come in contact with your eyes or lips. Do not apply it on skin that has been cut or scratched. Continue applying the product to complete the prescribed course of treatment, even after improvement is seen or felt. This product may discolour hair or clothing that it comes into contact with. Use caution when applying it. Children and pregnant women must avoid direct contact with a zone of application not washed or not covered with a garment. This medication is typically used only once a day. However, your pharmacist may have suggested a different schedule that is more appropriate for you. Apply it regularly and continuously to maintain its beneficial effect. Important: Follow the instructions on the label. Do not use more of this product, or more often, than prescribed. This product is to be applied only to affected areas. Avoid touching it with your fingers. To apply, use a finger cot (fingerstall) or an applicator.