Avamys

For adults and adolescents 12 years of age and older, the recommended dose is 2 sprays in each nostril once daily, preferably at the same time each day. For the best results, Avamys (Fluticasone-furoate-nasal) should be used regularly each day.

For children 2 to less than 12 years of age, the recommended starting dose is 1 spray in each nostril once daily. The doctor may suggest increasing the dose to 2 sprays in each nostril once daily until symptoms are controlled. Once the symptoms are under control, the doctor may suggest reducing the dose to 1 spray in each nostril once daily.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

If you are using Avamys (Fluticasone-furoate-nasal) for the first time, if you have not used it for more than 30 days, or if the cap has been left off for more than 5 days, you will need to "prime" the pump by spraying the pump in the air (away from you) 6 times or until a fine mist is sprayed from the bottle. Before each use, gently blow your nose to clear your nostrils.

With the cap on, shake the medication well. Then remove the cap and follow these 3 steps to use the medication:

• Tilt your head forward slightly and place the nozzle in one of your nostrils. Point the end of the nozzle towards the side of your nose.
• Press the button firmly one time to spray the medication while you are breathing in through your nose. Remove the nozzle from your nose and breathe out through your mouth.
• Repeat steps 1 and 2 for the other nostril.

If you are using 2 sprays in each nostril, repeat steps 1 to 3 again.

Avoid getting the spray in your eyes. If you do, thoroughly rinse your eyes with water. Always put the cap back on after use.

The contents of the bottle can be viewed through an indicator window. The nasal device should be discarded after the labelled number of sprays has been used. Beyond this, the correct amount of medication in each spray cannot be assured, even though the bottle is not completely empty.

It is important to use Avamys (Fluticasone-furoate-nasal) exactly as prescribed by your doctor. If you miss a dose of Avamys (Fluticasone-furoate-nasal) by several hours, skip the missed dose and continue with your regular dosing schedule. Do not double a dose to make up for a missed dose. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Avamys (Fluticasone-furoate-nasal) at room temperature in an upright position with the cap on, and keep it out of the reach of children. Do not refrigerate or freeze it.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

In addition to its desired action, this medication may cause some adverse effects, notably: it may cause headaches; it may cause nasal irritation; it may cause nosebleeds. Each person may react differently to a treatment. If you think this medication may be causing adverse effects (including those described here, or others), talk to your health care professional. He or she can help you to determine whether or not the medication is the source of the problem.

Fluticasone furoate nasal spray is an unscented, taste-free, alcohol-free, preserved aqueous suspension of micronized fluticasone furoate for topical administration to the nasal mucosa by means of a metering (50 µL), atomizing spray pump. Each bottle contains a net fill weight of 4.5 g or 10 g and will provide 30 or 120 metered sprays, respectively, after the initial priming. Each spray delivers a fine mist containing 27.5 µg of fluticasone furoate in 50 µL of formulation. Nonmedicinal ingredients: 0.015% w/w benzalkonium chloride, carboxymethylcellulose sodium, dextrose anhydrous, edetate disodium, microcrystalline cellulose, polysorbate 80, and purified water.

Fluticasone furoate nasal spray should not be used by anyone who is allergic to fluticasone furoate or to any of the ingredients of the medication.

There may be an interaction between fluticasone furoate nasal spray and any of the following:

• "azole" antifungals (e.g., ketoconzole, itraconazole, Voriconazole)
• Ceritinib
• Cobicistat
• delavirdine
• Desmopressin
• HIV protease inhibitors (atazanavir, darunavir, lopinavir, ritonavir, tipranavir)
• macrolide antibiotics (e.g., clarithromycin, erythromycin)
• Idelalisib

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Avamys (Fluticasone-furoate-nasal). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Avamys (Fluticasone-furoate-nasal).

Growth in children and adolescents: Corticosteroids such as fluticasone furoate nasal spray may impair the growth of children and adolescents. Your doctor will monitor for this. Talk to your doctor if you have any concerns.

Infections: Corticosteroids such as fluticasone furoate nasal spray may worsen existing infections, mask the signs of infection, and cause new infections. If you use Avamys (Fluticasone-furoate-nasal) for several months or longer, your doctor will monitor you periodically for signs of infection. People who have not had Chickenpox or Measles or have not been vaccinated against these infections should take special care to avoid exposure to them.

Liver function: Liver disease or reduced liver function may cause Avamys (Fluticasone-furoate-nasal) to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Avamys (Fluticasone-furoate-nasal) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Avamys (Fluticasone-furoate-nasal), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Avamys (Fluticasone-furoate-nasal).

Other corticosteroid medications: People who have been taking oral corticosteroids and are starting fluticasone furoate should be carefully monitored by their doctor. Changing from the oral form to the nasal spray can cause symptoms such as tiredness, aches, pains, and Depression. Tell your doctor if you have used or are using other corticosteroids. Your doctor will monitor you while you are taking Avamys (Fluticasone-furoate-nasal).

Vision problems: Corticosteroids such as fluticasone furoate nasal spray may cause Glaucoma or Cataracts. Report any vision changes to your doctor immediately. If you have glaucoma or cataracts, discuss with your doctor how Avamys (Fluticasone-furoate-nasal) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Avamys (Fluticasone-furoate-nasal), and whether any special monitoring is needed.

Wound healing: Corticosteroids such as fluticasone furoate nasal spray can impair the ability of wounds to heal. If you have ulcers in your nose, have had nasal surgery, or have had nasal trauma, talk to your doctor about how Avamys (Fluticasone-furoate-nasal) will affect these conditions. Your doctor may recommend waiting until wounds have completely healed.

Pregnancy: The safety of fluticasone furoate nasal spray use during pregnancy has not been established. Avamys (Fluticasone-furoate-nasal) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Avamys (Fluticasone-furoate-nasal), contact your doctor immediately.

Breast-feeding: It is not known if fluticasone furoate nasal spray passes into breast milk. If you are a breast-feeding mother and are taking Avamys (Fluticasone-furoate-nasal), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of Avamys (Fluticasone-furoate-nasal) have not been established for children under the age of 2 years.

This product is to be sprayed into the nostrils. To use: Blow your nose to clear your nostrils. Shake the container well. Tilt your head forward slightly. Spray the prescribed dose into the nostrils, breathing normally - do not sniff deeply. Wait 15 minutes after using the product before blowing your nose. Following its use, wipe the nozzle tip with a clean tissue or a smooth cloth. This medication is typically used only once a day. However, your pharmacist may have suggested a different schedule that is more appropriate for you. Important: Follow the instructions on the label. Do not use more of this product, or more often, than prescribed. It must be used regularly and continuously to maintain its beneficial effects. Be sure to keep an adequate supply on hand. If you forget a dose, take it as soon as you remember -- unless it is almost time for your next dose. In that case, skip the missed dose. Do not double the next dose to catch up.