Diacomit

The dose of stiripenol is based on body weight. The recommended dose is 50 mg per kilogram of body weight each day, divided into 2 or 3 equal doses. Diacomit (Stiripentol) should be started at a low dose and increased over 3 days to a daily dose of 50 mg per kilogram of body weight.

The capsule should be swallowed whole with a glass of water. Do not break or open the capsule.

The powder form of Diacomit (Stiripentol) should be mixed in a glass of water and taken immediately after mixing.

Diacomit (Stiripentol) should be taken with food as it breaks down in the acid that exists in an empty stomach. Avoid taking stiripenol with milk or dairy products, carbonated drinks, fruit juice or food and drinks that contain caffeine or Theophylline. Do not take Diacomit (Stiripentol) with alcoholic beverages.

If it is necessary to stop taking Diacomit (Stiripentol), the daily dose should be gradually reduced over the period of a month, to reduce the risk of seizures or increased frequency of seizures.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Diacomit (Stiripentol) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Diacomit (Stiripentol) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

250 mg
Each size 2 pink gelatin capsule contains 250 mg Diacomit (Stiripentol). Nonmedicinal ingredients: erythrosine, gelatin, indigotine, magnesium stearate, povidone, sodium starch glycolate, titanium dioxide.

500 mg
Each size 0 white gelatin capsule contains 500 mg Diacomit (Stiripentol). Nonmedicinal ingredients:gelatin, magnesium stearate, povidone, sodium starch, glycolate, titanium dioxide.

Powder for suspension

250 mg
Each packet of tutti frutti flavoured powder for suspension contains 250 mg Diacomit (Stiripentol). Nonmedicianl ingredients: aspartame, carmellose sodium, erythrosine, glucose, hydroxyethylcellulose, povidone, sodium starch glycolate, sorbitol, titanium dioxide, tutti frutti flavour.

500 mg
Each packet of tutti frutti flavoured powder for suspension contains 500 mg Diacomit (Stiripentol). Nonmedicianl ingredients: aspartame, carmellose sodium, erythrosine, glucose, hydroxyethylcellulose, povidone, sodium starch glycolate, sorbitol, titanium dioxide, tutti frutti flavour.

Do not take Diacomit (Stiripentol) if you are allergic to Diacomit (Stiripentol) or any ingredients of the medication.

There may be an interaction between Diacomit (Stiripentol) and any of the following:

• alcohol
• Alprazolam
• "azole" antifungals (e.g., itraconazole, ketoconazole, posaconazole)
• beta-blockers (e.g.,Carvedilol, Propranolol)
• caffeine
• calcium channel blockers (Amlodipine, Diltiazem, Verapamil)
• carbamazepine
• Chlorpheniramine
• Chlorpromazine
• cisapride
• Clobazam
• Codeine
• Cyclosporine
• Dextromethorphan
• Diazepam
• ergot alkaloids (e.g., ergotamine, Dihydroergotamine)
• Fentanyl
• Haloperidol
• HIV protease inhibitors (e.g., darunavir, lopinavir, ritonavir)
• macrolide antibiotics (e.g., azithromycin, clarithromycin, erythromycin)
• midazolam
• Omeprazole

• oral contraceptives
• phenobarbital
• phenytoin
• Pimozide
• quinidine
• selective serotonin reuptake inhibitors (SSRIs; Fluoxetine, paroxtine, Sertraline)
• Sirolimus
• "statin" cholesterol medications (e.g., Atorvastatin, Simvastatin)
• Tacrolimus
• theophylline
• Topiramate
• Tramadol
• Triazolam
• tricyclic antidepressants (e.g., Clomipramine, Imipramine)
• valproate

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Diacomit (Stiripentol). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Diacomit (Stiripentol).

Caffeine: Diacomit (Stiripentol) interacts with caffeine and other similar substances. People who take stiripenol should avoid colas, chocolate, coffee, tea and energy drinks.

Delirium and hallucinations: Rarely, Diacomit (Stiripentol) has been linked to delirium or hallucinations when taken by adults. If you have a history of psychoses or delirium, discuss with your doctor how Diacomit (Stiripentol) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Diacomit (Stiripentol), and whether any special monitoring is needed.

Drowsiness/Reduced Alertness: Diacomit (Stiripentol) may cause drowsiness or dizziness, affecting your ability to drive or operate machinery. Avoid these and other hazardous tasks until you have determined how Diacomit (Stiripentol) affects you.

Growth Problems: Diacomit (Stiripentol) can cause appetite loss and stomach upset which may result in loss of weight. For children this can result in growth problems. Your child's growth rate should be monitored by your doctor while taking Diacomit (Stiripentol). Talk to your doctor if your child is experiencing significant loss of appetite and weight loss.

Infection: Diacomit (Stiripentol) can reduce the number of cells that fight infection in the body (white blood cells). Tell your doctor immediately if you notice signs of an infection, such as fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness. Your doctor will do blood tests regularly to monitor the number of specific types of blood cells in your blood.

Kidney function: Reduced kidney function may cause Diacomit (Stiripentol) to build up in the body and cause side effects. If you have kidney problems, discuss with your doctor how Diacomit (Stiripentol) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Diacomit (Stiripentol), and whether any special monitoring is needed. Your doctor may want to test your kidney function regularly with blood tests while you are taking Diacomit (Stiripentol).

Liver function: The effect of reduced liver function on how the body uses Diacomit (Stiripentol) has not been studied. Diacomit (Stiripentol) may reduce liver function and can cause liver problems. If you have liver problems, discuss with your doctor how Diacomit (Stiripentol) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Diacomit (Stiripentol), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Diacomit (Stiripentol).

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately

Other medications for seizures: It is important to avoid taking Carbamazepine, Phenytoin or Phenobarbital when using Diacomit (Stiripentol). If you or your child are using any of these medications, discuss with your doctor the appropriate way to change medications.

Suicidal or agitated behaviour: People taking Diacomit (Stiripentol) may feel agitated (restless, anxious, aggressive, emotional, and feeling not like themselves), or they may want to hurt themselves or others. These symptoms may occur within several weeks after starting Diacomit (Stiripentol). If you experience these side effects or notice them in a family member who is taking Diacomit (Stiripentol), contact your doctor immediately. You should be closely monitored by your doctor for emotional and behaviour changes while taking Diacomit (Stiripentol).

Pregnancy: Although there is no information on the effect that Diacomit (Stiripentol) can have on the developing baby if it is taken by the mother during pregnancy, many medications that are used to treat seizures cause harm to the unborn baby. Diacomit (Stiripentol) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Diacomit (Stiripentol), contact your doctor immediately.

Breast-feeding: Diacomit (Stiripentol) may pass into breast milk. If you are a breast-feeding mother and are taking Diacomit (Stiripentol), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Seniors: There is no information regarding the safe and effective use of Diacomit (Stiripentol) by older adults. Seniors may be more likely to experience side effects because of liver and kidney impairment.