Estragyn

The recommended adult dose of conjugated estrogens ranges from 0.3 mg to 0.625 mg daily. Tablets can either be taken every day or in a cycle, such as 25 days on the medication each month and 5 days off. This medication should be used at the lowest dose for the shortest period of time possible.

Women who have not had their uterus removed should also take a progestogen (a different type of female hormone that protects the uterus from potential harmful effects caused by estrogen) for 10 to 14 days each month. Talk with your doctor or pharmacist about the advantages and disadvantages of the different dosing schedules of estrogen and progestogen.

It is important to have regular checkups with your doctor to decide if Estragyn (Estrogens-conjugated-synthetic) is still necessary.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to use Estragyn (Estrogens-conjugated-synthetic) exactly as prescribed by your doctor.

If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Estragyn (Estrogens-conjugated-synthetic) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

In addition to its desired action, this medication may cause some adverse effects, notably: it may cause headaches; when used, it may cause local irritation; it may cause nausea or, rarely, vomiting; it could cause water retention and swelling; it may increase breast size. Each person may react differently to a treatment. If you think this medication may be causing adverse effects (including those described here, or others), talk to your health care professional. He or she can help you to determine whether or not the medication is the source of the problem.

0.3 mg

Each yellow tablet contains 0.3 mg of esterified estrogens composed of sodium estrone sulphate and sodium equilin sulphate. Nonmedicinal ingredients: calcium carbonate, candy lacquer, lactose, magnesium stearate, mu-crystalline cellulose, sodium carboxymethylcellulose, starch, talc, tribasic calcium phosphate, FD&C Yellow No. 5, sodium benzoate, sucrose, and titanium dioxide.

0.625 mg

Each blue tablet contains 0.625 mg of esterified estrogens composed of sodium estrone sulphate and sodium equilin sulphate. Nonmedicinal ingredients: calcium carbonate, candy lacquer, lactose, magnesium stearate, mu-crystalline cellulose, sodium carboxymethylcellulose, starch, talc, tribasic calcium phosphate, FD&C Blue No. 1, FD&C Yellow No. 5, povidone, sodium benzoate, sucrose, and titanium dioxide.

Do not use esterified estrogens if you:

• are allergic to esterified estrogens or any ingredients of the medication
• are or may be pregnant
• are breast-feeding
• have known or suspected estrogen-dependent tumours such as breast or Uterine Cancer
• have abnormal liver test results caused by liver disease or liver problems
• have endometrial hyperplasia (overgrowth of the lining of the uterus)
• have a history of or suspected Breast Cancer
• have or have had a history of Blood Clots (e.g., in the legs or lungs), Heart Attack, Stroke, or heart disease
• have any vision problems or other vision problems due to ophthalmic vascular disease (disease involving blood vessels of the eye)
• have undiagnosed abnormal vaginal bleeding
• have a history of migraine Headaches with aura (classical migraine)

There may be an interaction between esterified estrogens and any of the following:

• acetylsalicylic acid (Asa)
• Anastrozole
• anticoagulants (e.g., Dalteparin, Enoxaparin, Warfarin, Apixaban, dabigatran, Rivaroxaban)
• ascorbic acid (vitamin C)
• Bosentan
• Carbamazepine
• Celecoxib
• corticosteroids (e.g., Hydrocortisone, Prednisolone, Prednisone)
• Cyclosporine
• Dabrafenib
• Deferasirox
• dehydroepiandosterone
• diabetes medications (e.g., chlorpropamide, glipizide, Glyburide, insulin, Metformin, Nateglinide, Rosiglitazone)
• efavirenz
• Enzalutamide
• etravirine
• Lenalidomide
• Mitotane
• Modafinil
• Phenobarbital
• Phenytoin
• primidone
• rifabutin
• rifampin
• Ropinirole
• St. John's wort
• Somatropin
• thalidomide
• theophyllines (e.g., Aminophylline, Oxtriphylline, Theophylline)
• thyroid medications (e.g., Levothyroxine, Liothyronine)
• Tocilizumab
• Ursodiol
• warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Estragyn (Estrogens-conjugated-synthetic). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Estragyn (Estrogens-conjugated-synthetic).

Note the following important information about estrogen replacement therapy: The Women's Health Initiative (WHI) study results indicated an increased risk of heart attack, stroke, breast cancer, blood clots in the lungs, and blood clots in the leg veins in postmenopausal women during 5 years of treatment with 0.625 mg conjugated equine estrogens and 2.5 mg medroxyprogesterone compared to women receiving sugar tablets. Other combinations of estrogen and progestins were not studied. However, until additional data are available, the risks should be assumed to be similar for other hormone replacement products. Therefore,

• estrogen with or without progestins should be used at the lowest dose that relieves your menopausal symptoms for the shortest time period possible, as directed by your doctor.
• estrogen with or without progestins should not be used to prevent heart disease, heart attacks, or strokes.

Blood clots: Estrogen with or without progestins is associated with an increased risk of blood clots in the lungs and legs. This risk also increases with age, a personal or family history of blood clots, smoking, and Obesity. The risk of blood clots is also increased if you are immobilized for prolonged periods and with major surgery. If possible, Estragyn (Estrogens-conjugated-synthetic) should be stopped 4 to 6 weeks before major surgery. Talk about the risk of blood clots with your doctor.

Breast cancer: Some studies have found an association between an increase in the risk of developing breast cancer and the use of hormone replacement therapy after menopause. Women who have a history of breast cancer should not use estrogens. If you have a family history of breast cancer, breast nodules, fibrocystic disease of the breast, or abnormal mammograms, you should be closely monitored by your doctor if you use estrogens. Women using estrogens should have regular breast examinations and should be taught how to do a breast self-examination. Your doctor may also recommend regular mammograms, depending on your age, risk factors, and previous mammogram results. Discuss the benefits and risks with your doctor so that you can make an informed choice about using Estragyn (Estrogens-conjugated-synthetic).

Dementia: Women over age 65 receiving combined estrogen and progestin replacement therapy may be at increased risk of developing dementia (loss of memory and intellectual function). If you are over 65 years of age, your doctor should closely monitor you for loss of memory and intellectual function.

Diabetes: People with diabetes should monitor their blood glucose closely to detect any changes in blood glucose control that sometimes occur with use of estrogens. If you have risk factors for diabetes, your doctor will monitor your blood glucose regularly while you are on Estragyn (Estrogens-conjugated-synthetic).

Endometrial cancer: Several studies suggest that estrogen replacement therapy increases the risk of cancer of the endometrium (uterus). Taking a progestin along with the estrogen reduces the risk to the same level as that of a woman not using estrogens. For this reason, all women who have not had their uterus removed should also take a progestin if they are using estrogens.

Fibroids: Estragyn (Estrogens-conjugated-synthetic) may worsen fibroids, causing sudden enlargement, pain, or tenderness. If you notice these effects, contact your doctor.

Gallbladder: An increased risk of gallbladder disease has been reported by postmenopausal women who take oral estrogens. If you experience symptoms of a gallbladder attack, such as severe pain on the right side of the abdomen, nausea, vomiting, and Fever, contact your doctor as soon as possible. If you have a history of gallbladder problems, discuss with your doctor how Estragyn (Estrogens-conjugated-synthetic) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Estragyn (Estrogens-conjugated-synthetic), and whether any special monitoring is needed.

Heart disease and stroke: Studies indicate an increased risk of heart disease and stroke with estrogen (with or without progestins) for postmenopausal women. Get immediate medical attention if you experience symptoms of a heart attack (chest pain, tightness or pressure, sweating, nausea, feeling of impending doom) or stroke (sudden dizziness, headache, loss of speech, changes in vision, weakness or numbness in the arms and legs) while taking Estragyn (Estrogens-conjugated-synthetic).

High Cholesterol or triglycerides: Estrogen may increase triglyceride (a type of fat found in the blood) levels, especially in those who already have high levels of triglycerides. If you have high levels of cholesterol or triglycerides, discuss with your doctor how Estragyn (Estrogens-conjugated-synthetic) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function (the liver makes cholesterol and triglycerides) regularly with blood tests while you are taking Estragyn (Estrogens-conjugated-synthetic).

Liver disease: Estrogens may reduce liver function and can cause liver failure. If you have liver problems, discuss with your doctor how Estragyn (Estrogens-conjugated-synthetic) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Estragyn (Estrogens-conjugated-synthetic).

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Ovarian Cancer: Several studies suggest that estrogen replacement therapy increases the risk of cancer of the ovaries, especially when taken for 5 years or longer. This may occur whether you are taking a progestin or not. If you are at an increased risk of developing ovarian cancer, discuss with your doctor how Estragyn (Estrogens-conjugated-synthetic) may affect your risk, whether any special monitoring is needed, and whether this medication is appropriate for you.

Porphyria: Estrogens may worsen symptoms of porphyria. If you have porphyria, discuss with your doctor how Estragyn (Estrogens-conjugated-synthetic) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Estragyn (Estrogens-conjugated-synthetic), and whether any special monitoring is needed.

Seizures: Estrogens may cause an increase in the frequency of seizures for women who experience seizures or have a history of seizures. If you have a history of seizures, discuss with your doctor how Estragyn (Estrogens-conjugated-synthetic) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Thyroid disease: Estrogens can affect how well the thyroid gland works. If you have thyroid disease such as Hypothyroidism (low thyroid levels), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Estragyn (Estrogens-conjugated-synthetic), and whether any special monitoring is needed.

Water retention: Estrogen may cause sodium (salt) and water retention, making symptoms worse for people with certain medical conditions such as Epilepsy, Asthma, and kidney or heart dysfunction. If you have any of these medical conditions, discuss with your doctor how Estragyn (Estrogens-conjugated-synthetic) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Estragyn (Estrogens-conjugated-synthetic), and whether any special monitoring is needed.

Pregnancy: Estrogen should not be used during pregnancy. If you become pregnant while using this medication, contact your doctor immediately.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are using esterified estrogens, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of Estragyn (Estrogens-conjugated-synthetic) have not been established for children less than 16 years of age.

This medication is to be used vaginally. As this product may leak and stain your underwear, you are advised to wear a sanitary napkin during the treatment. Use the product for the prescribed period of time and follow the directions for use included in the package.<br/><br/>When applying this product, you may feel a slight irritation at first. If the irritation becomes severe or continues longer than a few minutes, consult your health care professional. WARNING: This product can reduce the effectiveness of some methods of contraception (e.g.: condoms, diaphragms) during treatment and for 72 hours after it is completed. This medication is typically used only once a day. However, your pharmacist may have suggested a different schedule that is more appropriate for you. Important: Follow the instructions on the label. Do not use more of this product, or more often, than prescribed.