Mozobil

Mozobil (Plerixafor) is given by subcutaneous (under the skin) injection, usually in the abdominal area.

The recommended adult dose of Mozobil (Plerixafor) is based on body weight, calculated as 0.24 mg per kilogram of body weight, to a maximum of 40 mg daily. It is usually given as a single dose approximately 10 to 11 hours before the procedure to gather stem cells from the blood.

Mozobil (Plerixafor) is generally given under the supervision of a doctor in a hospital or similar setting with access to sterile equipment for preparation.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Mozobil (Plerixafor) exactly as prescribed by your doctor.

It is important Mozobil (Plerixafor) be given exactly as recommended by your doctor. If you miss an appointment to receive Mozobil (Plerixafor), contact your doctor as soon as possible to reschedule your appointment.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Each 1 mL of sterile, preservative-free, clear, colorless to pale yellow, isotonic solution contains 20 mg of Mozobil (Plerixafor). Nonmedicinal ingredients: sodium chloride in sterile water for injection, adjusted to a pH of 6.0 to 7.5 with hydrochloric acid and sodium hydroxide, if required.

Do not take Mozobil (Plerixafor) if you are allergic to Mozobil (Plerixafor) or any ingredients of the medication.

Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Mozobil (Plerixafor).

Blood counts: Mozobil (Plerixafor) can increase the number of white blood cells and decrease the number of platelets (which help your blood to clot). Your doctor will do blood tests to monitor this. If you notice any signs of infection (e.g., Fever, chills, or sore throat) or unusual bleeding or bruising, contact your doctor immediately.

Blood Pressure: Mozobil (Plerixafor) may cause low blood pressure or dizziness and lightheadedness when rising from a lying or sitting position. People taking medications that can cause dizziness should rise slowly from sitting or lying down to reduce the possibility of severe dizziness or fainting.

Drowsiness/reduced alertness: Mozobil (Plerixafor) may cause drowsiness or dizziness, affecting your ability to drive or operate machinery. Avoid these and other hazardous tasks until you have determined how Mozobil (Plerixafor) affects you.

Electrolyte balance: Mozobil (Plerixafor) may cause the levels of electrolytes such as potassium, sodium, magnesium, chloride, and calcium in the blood to change while taking Mozobil (Plerixafor). If you experience symptoms of fluid and electrolyte imbalance such as muscle pains or cramps; Dry Mouth; numb hands, feet, or lips; or racing heartbeat, contact your doctor as soon as possible. Your doctor will do blood tests regularly to monitor the levels of these electrolytes in your blood while you are taking Mozobil (Plerixafor).

Heart attack: Although rare, Mozobil (Plerixafor) has been associated with heart attack. If you experience signs of a heart attack such as chest pain or pressure, pain extending through shoulder and arm, nausea and vomiting, sweating, let your doctor know immediately.

Kidney function: Kidney Disease or reduced kidney function may cause Mozobil (Plerixafor) to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how Mozobil (Plerixafor) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Mozobil (Plerixafor), and whether any special monitoring is needed.

Pregnancy: Mozobil (Plerixafor) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Mozobil (Plerixafor), contact your doctor immediately. Women who may become pregnant should use effective birth control while being treated with Mozobil (Plerixafor).

Breast-feeding: It is not known if Mozobil (Plerixafor) passes into breast milk. If you are a breast-feeding mother and are taking Mozobil (Plerixafor), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Mozobil (Plerixafor) have not been established for children.