Novolin Ge Tor Penfill 3

Your required dose of regular insulin depends on how much natural insulin your pancreas is producing and how well your body is able to use it. Your doctor or diabetes educator will determine the appropriate dose for you according to various lifestyle factors and the blood glucose values obtained while monitoring your blood glucose.

Your dose of regular insulin should be injected subcutaneously (under the skin) exactly as instructed by your doctor or diabetes educator. Do not inject regular insulin into the vein and do not use regular insulin in insulin infusion pumps. The dose of insulin is measured in international units (IU). Each mL of insulin contains 100 IU. Regular insulin is injected about 30 minutes before certain meals. Longer-acting insulins are often used along with regular insulin to cover the time between doses of regular insulin. There are many variations of insulin dosing.

Regular insulin should be clear and colourless. Do not use the insulin if you notice anything unusual in the appearance of the solution, such as cloudiness, discolouration, or clumping.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones given here, do not change the way that you are using the medication without consulting your doctor.

It is very important that you use Novolin Ge Tor Penfill 3 (Insulin-human-regular) exactly as prescribed by your doctor. The timing of insulin with respect to your meals is crucial to keeping blood glucose under control and preventing unwanted side effects.

Keep unopened bottles of insulin in the refrigerator until needed. They may be used until the expiry date on the label. Never allow insulin to freeze. Insulin that is currently in use may be kept at room temperature for no more than 28 days and then discarded. Do not expose insulin to extremely hot temperatures or to sunlight. Keep insulin out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Aside from the risk of hypoglycemia (low blood sugar levels), this product has few adverse effects. If you think this medication may be causing adverse effects, talk to your health care professional. He or she can help you to determine whether or not the medication is the source of the problem.

Novolin® ge Toronto injection
Each mL vial contains 100 units of human biosynthetic insulin (regular insulin). Nonmedicinal ingredients: glycerol, hydrochloric acid and/or sodium hydroxide (for pH adjustment), metacresol, water for injection, and zinc chloride.

Novolin® ge Toronto Penfill
Each mL vial contains 100 units of human biosynthetic insulin (regular insulin). Nonmedicinal ingredients: glycerol, hydrochloric acid and/or sodium hydroxide (for pH adjustment), metacresol, water for injection, and zinc chloride.

Regular insulin should not be used by anyone who:

• is allergic to insulin or to any of the ingredients of the medication
• has low blood glucose (Hypoglycemia)

There may be an interaction between regular insulin and any of the following:

• alcohol
• anabolic steroids (e.g., testosterone)
• angiotensin converting enzyme inhitors (ACE inhibitors;(e.g., Ramipril, Enalapril, Lisinopril)
• second generation anti-psychotics (e.g., Clozapine, Olanzapine, Quetiapine)
• beta-blockers (e.g., Atenolol, Metoprolol, Pindolol, Propranolol, Sotalol)
• birth control pills
• chloroquine
• corticosteroids (e.g., Prednisone, Prednisolone)
• Dabrafenib
• Danazol
• decongestants (e.g., Pseudoephedrine)
• disopyromide
• diuretics (water pills; e.g., Furosemide, Hydrochlorothiazide, triamterene)
• Epinephrine
• estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol
• glucagon
• growth hormone
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• hydroxychloroquine
• Lanreotide
• mifepristone
• monoamine oxidase inhibitors (M.O.S. e.g., Moclobemide, Phenelzine, Rasagiline, Selegiline, Tranylcypromine)
• Niacin
• Octreotide
• oral medications for diabetes (e.g., Canagliflozin, Gliclazide, Glyburide, Pioglitazone, Metformin, Rosiglitazone)
• other insulins
• Pasireotide
• Pegvisomant
• Phenytoin
• progestins (e.g., Dienogest, Levonorgestrel, medroxyprogesterone, Norethindrone)
• quinine
• quinolone antibiotics (e.g., ciprofloxacin, Norfloxacin, Ofloxacin)
• salicylates (e.g., Asa)
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• somatostatin
• sulfa antibiotics (e.g., sulfamethoxazole, sulfadiazine)
• Sunitinib
• Tacrolimus
• thyroid replacement therapy (if beginning or changing dose)
• Vorinostat

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Novolin Ge Tor Penfill 3 (Insulin-human-regular). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Novolin Ge Tor Penfill 3 (Insulin-human-regular).

Allergic reactions: If you notice signs of a serious allergic reaction (e.g., swelling of the face or throat, difficulty breathing, wheezing, or an itchy skin rash), stop taking the medication and seek immediate medical attention.

Appearance of insulin: The contents of the vial of regular insulin should be clear and colourless. Do not use Novolin Ge Tor Penfill 3 (Insulin-human-regular) if you notice anything unusual about its appearance, such as cloudiness, discoloration, or clumping.

Blood glucose monitoring: It is important for anyone using insulin to monitor their blood glucose levels regularly, as recommended by their doctor or diabetes educator. It is especially important to test blood glucose more often when your insulin dose or schedule changes, or when you are ill or under stress. If blood tests consistently show high or low blood glucose levels, contact your doctor or diabetes educator.

Changes at injection site: Fatty tissue under the skin at the injection site may shrink or thicken if you inject yourself too often at the same site. To help avoid this effect, change the site with each injection. Talk to your doctor or diabetes educator if you notice your skin pitting or thickening at the injection site.

Changes in insulin requirements: Many things can affect blood glucose levels and insulin requirements. These include:

• certain medical conditions (e.g., infections, Thyroid conditions, or kidney or liver disease)
• certain medications that increase or decrease blood glucose levels
• diet
• exercise
• illness
• injury
• stress
• surgery
• travelling over time zones

It is important your doctor knows your current health situation and any changes that may affect the amount of regular insulin you need. Blood glucose should be monitored regularly, as recommended by your doctor or diabetes educator.

Diabetes identification: It is important to either wear a bracelet (or necklace) or carry a card indicating you have diabetes and are taking insulin.

Family and friends: Educate your family and friends about the signs and symptoms of hypoglycemia (low blood glucose). Keep a Glucagon kit available and instruct them on its proper use in case you experience severe low blood glucose and you lose consciousness.

High blood glucose (hyperglycemia): Hyperglycemia can occur if not enough insulin is used or if you routinely forget to use your insulin. If this is not treated, it can result in diabetic ketoacidosis or coma, which can be fatal. Ability to concentrate and react, as well as vision changes, are affected by high levels of blood glucose. The first symptoms of hyperglycemia include an increased need to urinate, nausea, vomiting, drowsiness, excessive thirst, weight loss, loss of appetite, and an acetone or fruity odour to the breath. If you notice any of these symptoms, contact your doctor immediately.

Low blood glucose (hypoglycemia): Hypoglycemia may occur if too much insulin is used, if meals are missed, or if you exercise more than usual. Symptoms of mild to moderate hypoglycemia may occur suddenly and can include cold sweat, nervousness or shakiness, fast heartbeat, headache, hunger, confusion, lightheadedness, weakness, and numbness or tingling of the tongue, lips, or fingers. Mild to moderate hypoglycemia may be treated by eating foods or drinks that contain sugar. People taking insulin should always carry a quick source of sugar, such as hard candies, glucose tablets, juice, or regular soft drinks (not diet soft drinks).

Signs of severe hypoglycemia can include disorientation, loss of consciousness, and seizures. People who are unable to take sugar by mouth or who are unconscious may require an injection of glucagon or treatment with intravenous (into the vein) glucose.

Pregnancy: It is essential to maintain good blood glucose control throughout pregnancy. Insulin requirements usually decrease during the first trimester and increase during the second and third trimesters.

Breast-feeding: Breast-feeding mothers may require adjustments in their insulin dose or diet.

This product must be injected under the skin (subcutaneously): Clean the tip of the cartridge with an alcohol swab and attach a needle. Select the required dose. Clean the skin at the injection site with an alcohol swab. Pinch the skin and inject the insulin into the fold. If you use a short needle, pinching the skin may not be necessary, ask your pharmacist. Wait a few days before injecting the same site again. Keep the injector and the cartridge you are using at room temperature and discard the cartridge after 28 days. Unopened cartridges should be stored in the refrigerator. Use this medication regularly and continuously to maintain its beneficial effects. Insulin users should be aware of the symptoms of low blood sugar, which include confusion, headache, hunger, mood changes, palpitations, rapid breathing, cold sweats and shakiness. These symptoms require immediate treatment, to bring your blood sugar back up to a safe level. This can be done with a quick source of sugar, such as: 4 or 5 glucose tablets 59 to 79 mL of liquid glucose 15 to 20 mL (3 or 4 teaspoons) of honey, maple syrup or corn syrup 6 to 8 LifeSavers type candies 150 to 200 mL (2/3 to 3/4 cup) of fruit juice or regular soft drink (not a diet soft drink) 4 or 5 packets of white sugar (3 or 4 teaspoons) dissolved in water Inform your health care professional if these symptoms have occurred, as it may mean that your diet and/or medication needs to be adjusted.<br/><br/>Insulin users must check their blood sugar levels regularly using an appropriate device. Dispose of used syringes and needles safely. Your pharmacist can tell you the best way to do this. If you miss a dose, contact your pharmacist. Never double a dose to make up for a missed dose. In order not to cause hypoglycemia, avoid excessive alcohol consumption. Do not drink alcohol on an empty stomach.