Typhim Vi

For adults and children 2 years of age and older, one dose is injected into the outer muscle of the upper arm or the thigh. A qualified health professional will inject the vaccine.

The typhoid vaccine should be given at least 14 days before entering the typhoid risk area for greatest protection from typhoid infection.

A repeat vaccination ("booster") is recommended every 3 years if you repeatedly travel to areas where you are exposed to S. typhi.

The typhoid vaccine may be given at the same time as some other vaccinations as long as they are injected into different areas of the body.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Store Typhim VI (Typhoid-vaccine-inactivated) in the refrigerator, do not freeze, protect it from light, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Each 0.5 mL dose of sterile, clear, colourless solution for intramuscular injection contains Salmonella typhi (TY2 strain) purified Vi capsular polysaccharide 25 µg. Nonmedicinal ingredients: phenol (as preservative) and isotonic buffer solution.

Do not take Typhim VI (Typhoid-vaccine-inactivated) if you:

• are allergic to typhoid vaccine or any ingredients of the medication
• have a fever or severe illness at the time of vaccination

There may be an interaction between typhoid vaccine and any of the following:

• antineoplastic or chemotherapy medications
• corticosteroids (e.g., Dexamethasone, Prednisone)
• immunosuppressants (e.g., Azathioprine, Cyclosporine, Fingolimod, hydroxychloroquine, Leflunomide, Tacrolimus)
• other live vaccines

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Typhim VI (Typhoid-vaccine-inactivated). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Typhim VI (Typhoid-vaccine-inactivated).

Allergic reactions: Rarely, this vaccine may cause severe allergic reactions. If you notice the signs of a Anaphylaxis (severe allergic reaction) (Hives; trouble breathing or swallowing; or swelling of the lips, face, throat, or tongue) get medical attention immediately.

Bleeding problems: If you have blood clotting problems or are currently taking blood thinners (oral anticoagulants), notify your doctor prior to injection.

Immunocompromised people: Typhoid vaccine may not be as effective for people with a compromised immune system (e.g., people with AIDS, people receiving chemotherapy, or people taking any medication that suppresses the immune system). People with any of these conditions should discuss with their doctor how Typhim VI (Typhoid-vaccine-inactivated) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Typhim VI (Typhoid-vaccine-inactivated), and whether any special monitoring is needed.

Infection and fever: Delay receiving the typhoid vaccine if you have an infection or fever, unless, in the opinion of your doctor, the benefits of receiving the vaccine while you are ill outweigh the risks.

Protection against typhoid: Not all people who take the vaccine will be fully protected against typhoid. This is especially so if the vaccine is given less than 2 weeks before arriving in the areas with typhoid exposure risk.

Pregnancy: The effects of Typhim VI (Typhoid-vaccine-inactivated) on an unborn baby are not known. Typhim VI (Typhoid-vaccine-inactivated) should not be used during pregnancy unless the benefits outweigh the risks. If you are or may be pregnant, discuss the risks and benefits of using this vaccine with your doctor.

Breast feeding: It is not known if typhoid vaccine passes into breast milk. If you are a breast-feeding mother and are taking Typhim VI (Typhoid-vaccine-inactivated), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Typhim VI (Typhoid-vaccine-inactivated) have not been established for children under 2 years of age.