Movantik

The recommended dose of Movantik (Naloxegol) is 25 mg taken by mouth, once daily. Depending on any side effects you experience, your doctor may suggest a lower dose.

It is recommended that Movantik (Naloxegol) be taken on an empty stomach in the morning. Therefore, it should be taken 1 hour before the first meal of the day or 2 hours after.

When you first start taking Movantik (Naloxegol), stop taking other laxatives until you determine how well Movantik (Naloxegol) works for you. You may have a bowel movement within 12 hours after taking the first dose of Movantik (Naloxegol).

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Movantik (Naloxegol) exactly as prescribed by your doctor.

If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is less than 12 hours until your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Movantik (Naloxegol) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

In addition to its desired action, this medication may cause some adverse effects, notably: it may cause headaches; it may cause diarrhea; it may cause stomach ache; it may cause gas and bloating; it may cause nausea or, rarely, vomiting; it may cause heavy perspiration. Each person may react differently to a treatment. If you think this medication may be causing adverse effects (including those described here, or others), talk to your health care professional. He or she can help you to determine whether or not the medication is the source of the problem.

12.5 mg
Each oval, biconvex, mauve, film-coated tablet, intagliated with "12.5" on one side and "nGL" on the other, contains 12.5 mg of Movantik (Naloxegol). Nonmedicinal ingredients: mannitol, microcrystalline cellulose, croscarmellose sodium, propyl gallate, and magnesium stearate. Tablet coating: hypromellose, titanium dioxide, macrogol 400, iron oxide red, and iron oxide black.

25 mg
Each oval, biconvex, mauve, film-coated tablet, intagliated with "25" on one side and "nGL" on the other, contains 25 mg of Movantik (Naloxegol). Nonmedicinal ingredients: mannitol, microcrystalline cellulose, croscarmellose sodium, propyl gallate, and magnesium stearate. Tablet coating: hypromellose, titanium dioxide, macrogol 400, iron oxide red, and iron oxide black.

Do not take Movantik (Naloxegol) if you:

• are allergic to Movantik (Naloxegol) or any ingredients of the medication
• have or may have a blockage in the digestive tract
• have a history of blockage in the digestive tract
• are taking any of the following medications:
  • "azole" antifungals (e.g., ketoconazole, Voriconazole)
  • HIV protease inhibitors (e.g., ritonavir, lopinavir)
  • macrolide antibiotics (e.g., clarithromycin, erythromycin)

There may be an interaction between Movantik (Naloxegol) and any of the following:

• Abiraterone acetate
• Amiodarone
• Aprepitant
• Atorvastatin
• "azole" antifungals (e.g., itraconazole, ketoconazole, voriconazole)
• boceprevir
• Bosentan
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
• Carbamazepine
• Cobicistat
• conivaptan
• Cyclosporine
• daclatasvir
• Deferasirox
• Dronedarone
• Enzalutamide
• Eslicarbazepine
• grapefruit juice
• HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, etravirine, nevirapine)
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• ledipasvir
• macrolide antibiotics (e.g., clarithromycin, erythromycin)
• Methadone
• Methylnaltrexone
• mifepristone
• Mitotane
• Modafinil
• Naloxone
• Naltrexone
• nefazodone
• Phenobarbital
• Phenytoin
• primidone
• certain protein kinase inhibitors (e.g., Crizotinib, Dabrafenib, imatinib, Lapatinib, Nilotinib)
• quinidine
• quinine
• rifabutin
• rifampin
• St. John's wort
• simeprevir
• Stiripentol
• Tocilizumab

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Movantik (Naloxegol). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Movantik (Naloxegol).

Gastrointestinal perforation: People with advanced illness who use Movantik (Naloxegol) may be at increased risk of gastrointestinal perforation (a hole that forms in the wall of the gastrointestinal tract, such as through the stomach or intestines). People are especially at risk if they also have a weakened gastrointestinal wall due to conditions such as cancer, intestinal cancer, or gastrointestinal cancer. If you experience severe, worsening, or persistent abdominal pain that's intensified by movement, or accompanied by Fever, chills, nausea or vomiting, seek immediate medical attention. These could be symptoms of gastrointestinal perforation, which is a medical emergency.

Kidney Function: Kidney Disease or reduced kidney function may cause Movantik (Naloxegol) to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how Movantik (Naloxegol) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Movantik (Naloxegol), and whether any special monitoring is needed.

Opioid withdrawal: Very rarely, Movantik (Naloxegol) may block the effects of opioids on the nervous system. This can result in symptoms of withdrawal. If you experience unusual sweating, mood swings, nausea or vomiting, muscle aches, tearing, diarrhea, yawning, or difficulty sleeping, contact your doctor.

Pregnancy: Movantik (Naloxegol) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Movantik (Naloxegol), contact your doctor immediately.

Breast-feeding: It is not known if Movantik (Naloxegol) passes into breast milk. If you are a breast-feeding mother and are taking Movantik (Naloxegol), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Movantik (Naloxegol) have not been established for children.

This medication is typically used only once a day. However, your pharmacist may have suggested a different schedule that is more appropriate for you. Take it regularly and continuously to maintain its beneficial effects. Important: Follow the instructions on the label. Do not use more of this product, or more often, than prescribed. This medication should be swallowed whole. If you have trouble swallowing the tablet whole, contact your pharmacist. If you remember missing a dose within 12 hours of the time it is usually taken, take it as soon as you remember, then take the next dose at the regularly scheduled time. If the dose is missed by more than 12 hours, skip the missed dose. Do not double the next dose to catch up. This medication should not be taken with food. It is best taken on an empty stomach in the morning, one hour before or 2 hours after the first meal of the day. Avoid grapefruit and grapefruit juice during your treatment. Grapefruit can seriously affect how this medication works.