Narcan Nasal

Before using Narcan Nasal (Naloxone), call 9-1-1 to request emergency medical assistance. Narcan Nasal (Naloxone) should not be used as a substitute for professional medical care.

Narcan Nasal (Naloxone) nasal spray is available as a 2 mg or a 4 mg spray device. The lowest available strength should be used as the starting dose. If the person responds to the first dose, but overdose symptoms reappear before emergency help arrives, administer additional doses of Narcan Nasal (Naloxone). If the person does not respond to the first dose of Narcan Nasal (Naloxone) after 2 to 3 minutes, administer repeated doses of Narcan Nasal (Naloxone) as necessary.

Each nasal spray device contains a single dose of Narcan Nasal (Naloxone) and cannot be reused. To administer Narcan Nasal (Naloxone) nasal spray, place patient on their back. Support the back of the neck to allow the head to tilt back. Ensure the device nozzle is inserted in either nostril and press firmly on the device plunger. Remove the device nozzle after use.

If repeat doses are needed, alternate nostrils for each dose.

If you are not sure how to use the nasal spray, or have questions about how to use it, contact your doctor or pharmacist. Before using Narcan Nasal (Naloxone), thoroughly read the patient information provided and ask your doctor if you have any questions.

Store Narcan Nasal (Naloxone) at room temperature, protect it from light, and keep it out of the reach of children. Do not expose it to extremes of heat or cold temperatures.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

In addition to its desired action, this medication may cause some adverse effects, notably: it may affect your heart rate; it may cause diarrhea; it may increase your blood pressure; it may cause nausea or, rarely, vomiting; it may cause heavy perspiration; it may cause shakiness. Each person may react differently to a treatment. If you think this medication may be causing adverse effects (including those described here, or others), talk to your health care professional. He or she can help you to determine whether or not the medication is the source of the problem.

2 mg/0.1 mL
Each sprayer containing 0.1 mL of aqueous solution for intranasal administration contains 2 mg of Narcan Nasal (Naloxone). Nonmedicinal ingredients: benzalkonium chloride, disodium ethylenediaminetetraacetate (stabilizer), sodium chloride, hydrochloric acid to adjust pH, and purified water.

4 mg/0.1 mL
Each sprayer containing 0.1 mL of aqueous solution for intranasal administration contains 4 mg of Narcan Nasal (Naloxone). Nonmedicinal ingredients: benzalkonium chloride, disodium ethylenediaminetetraacetate (stabilizer), sodium chloride, hydrochloric acid to adjust pH, and purified water.

Do not take Narcan Nasal (Naloxone) if you are allergic to Narcan Nasal (Naloxone) or any ingredients of the medication.

There may be an interaction between Narcan Nasal (Naloxone) and any of the following:

• cannabis
• Cobicistat
• Methylnaltrexone
• Nabilone
• Naloxegol

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Narcan Nasal (Naloxone). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Narcan Nasal (Naloxone).

Non-opioid overdoses: Narcan Nasal (Naloxone) does not reduce the effects of an overdose caused by other medications such as barbiturates, benzodiazepines, stimulants, alcohol, or other sedatives. Giving Narcan Nasal (Naloxone) to a person who is unconscious due to a non-opioid overdose is not likely to cause them more harm.

Opioid dependence: When given to a person who has been using opioids for a long time, Narcan Nasal (Naloxone) may cause withdrawal symptoms similar to stopping the opioid suddenly. These symptoms can include body aches, diarrhea, nausea, nervousness, restlessness, runny nose, sneezing, goose bumps, shaking, shivering, nausea, stomach cramps, fast or irregular heart rate, Fever, sweating, increased blood pressure, and possible seizures.

Rebound opioid toxicity: The effects of Narcan Nasal (Naloxone) are shorter than the effects of opioids. As a result, symptoms of overdose may reappear when Narcan Nasal (Naloxone) wears off. Additional doses of Narcan Nasal (Naloxone) may be required.

Recent surgery: Narcan Nasal (Naloxone) should be used with caution in someone who has had recent surgery. Side effects such as blood pressure changes, increased heart rate, irregular heartbeat, fluid build-up in the lungs and Heart Attack have been reported.

Pregnancy: The effects of Narcan Nasal (Naloxone) on a developing baby are unknown. Narcan Nasal (Naloxone) should not be used during pregnancy unless the benefits outweigh the risks.

Breast-feeding: It is not known if Narcan Nasal (Naloxone) passes into breast milk. If you are a breast-feeding mother and are taking Narcan Nasal (Naloxone), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

This product must be used in one nostril. To use: Emergency medical assistance (911) must be requested. The patient should be placed in the supine position. Provide support to the back of the neck to allow the head to tilt back. The device nozzle should be inserted in either nostril. The piston of the device must be firmly pressed. The device nozzle should be removed from the nostril after use. The patient should be turned on the side. Generally, this medication is used only as needed. Important: Follow the instructions on the label. Do not use more of this product, or more often, than prescribed.