Sulfinpyrazone

The recommended starting dose of sulfinpyrazone is 100 mg twice daily. Depending on your response to the medication, your doctor may gradually increase your dose up to 800 mg daily (e.g., 200 mg 4 times daily). The usual daily dose for chronic gout is 200 mg to 400 mg.

Sulfinpyrazone may be taken with or without food. If the medication upsets your stomach, you may take it with food. If you still experience problems, you may take the medication with an antacid. Your doctor may want you to drink up to 8 to 10 glasses of water daily when you first start taking Sulfinpyrazone. It is important that you follow your doctor's directions carefully, to avoid the formation of acidic urine.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Sulfinpyrazone exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Sulfinpyrazone (AA Pharma)

Each white, round, film-coated tablet, engraved "200" on one side, contains sulfinpyrazone 200 mg. Ask your pharmacist or doctor for details.

Do not take sulfinpyrazone if you:

• are allergic to sulfinpyrazone or any ingredients of the medication
• are allergic to acetylsalicylic acid (Asa) or non-steroidal anti-inflammatory medications
• have a history of blood disorders or blood coagulation disorders
• have an active ulcer

There may be an interaction between sulfinpyrazone and any of the following:

• Acetaminophen
• Amiodarone
• Aprepitant
• Aripiprazole
• Bosentan
• Carbamazepine
• Carvedilol
• Celecoxib
• chlorpropamide
• Cyclosporine
• dabigatran
• delaviridine
• Dipyridamole
• efavirenz
• Fenofibrate
• Fluoxetine
• fosphenytoin
• Fluorouracil
• Gemfibrozil
• glipizide
• Glyburide
• Heparin
• ketamine
• ketoconazole
• Leflunomide

• mestranol
• Montelukast
• nonsteroidal anti-inflammatory drugs (NSAIDs; e.g., Ibuprofen, Naproxen)
• mifepristone
• Omeprazole
• peginterferon Alfa-2b
• Phenobarbital
• Phenytoin
• primidone
• rifampin
• salicylates (e.g., ASA, salsalate)
• saxagliptan
• secobarbital
• Sorafenib
• sulfadiazine
• sulfamethoxazole
• sulfisoxazole
• Tamoxifen
• Tolbutamide
• Trimethoprim
• Valproic acid
• Voriconazole
• Warfarin
• Zafirlukast

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Sulfinpyrazone. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Sulfinpyrazone.

Allergy: Some people who are allergic to acetylsalicylic acid (ASA) also experience allergic reactions sulfinpyrazone. Before you take sulfinpyrazone, inform your doctor about any previous adverse reactions you have had to medications, especially ASA. Contact your doctor at once if you experience signs of an allergic reaction, such as skin rash, itching, difficulty breathing or swelling of the face and throat.

Diabetes: Sulfinpyrazone may cause a loss of control of diabetes by increasing blood glucose (sugar). If you have diabetes or are at risk of developing diabetes, discuss with your doctor how Sulfinpyrazone may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Sulfinpyrazone, and whether any special monitoring is needed. You may need to check your blood glucose levels more often.

Fluids: If you are prone to gout (high uric acid levels) and also take diuretics (water pills), make sure to drink lots of fluids. Your doctor may want you to start with a low dose of sulfinpyrazone. At the start of treatment, attacks of gout may occur more frequently because uric acid is being freed from affected joints. Therefore, maintain an adequate fluid intake. If an attack of gout occurs, sulfinpyrazone should be continued but your doctor will likely add other treatments (e.g., Colchicine or nonsteroidal anti-inflammatory drugs [but not ASA]).

Kidney function: Sulfinpyrazone may cause sodium and water retention. If you have a history of Kidney Disease or reduced kidney function, discuss with your doctor how Sulfinpyrazone may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Sulfinpyrazone, and whether any special monitoring is needed.

Stomach problems: Sulfinpyrazone may cause stomach problems or re-activate stomach ulcers. If you have a history of stomach problems, healed peptic ulcer or active ulcers, discuss with your doctor how Sulfinpyrazone may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Sulfinpyrazone, and whether any special monitoring is needed.

Pregnancy: Sulfinpyrazone should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Sulfinpyrazone, contact your doctor immediately.

Breast-feeding: It is not known if sulfinpyrazone passes into breast milk. If you are a breast-feeding mother and are taking Sulfinpyrazone, it may affect your baby. Talk to your doctor about whether you should continue breastfeeding.