Dipyridamole

The recommended oral adult dose of dipyridamole for preventing blood clots is 100 mg 4 times daily one hour before meals. If taken with 1000 mg of Asa daily, the dose of dipyridamole can be reduced to 25 mg 4 times daily.

When used for medical tests that examine how well blood is flowing through the heart, dipyridamole is given by injection in a hospital.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Dipyridamole exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Dipyridamole at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Intravenous solution: Each mL contains 5 mg of dipyridamole. Nonmedicinal ingredients: tartaric acid, polyethylene glycol 600, hydrochloric acid, and water for injection.

Do not take dipyridamole if you are allergic to dipyridamole or any ingredients of the medication.

Do not give the injectable form of Dipyridamole to anyone who is in a state of shock or collapse.

There may be an interaction between dipyridamole and any of the following:

• acetylsalicylic acid (ASA)
• Aliskiren
• alpha blockers (e.g., Alfuzosin, Doxazosin, Tamsulosin)
• alpha agonists (e.g., Clonidine, methyldopa)
• Amiodarone
• anti-cancer medications (e.g., Doxorubicin, Etoposide, Topotecan, Vinblastine)
• Apixaban
• beta-adrenergic blockers (e.g., Atenolol, Propranolol, Sotalol)
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
• Carvedilol
• cetirizine
• ciprofloxacin (systemic)
• cholinesterase inhibitors (e.g., Donepezil, Galantamine, Rivastigmine)
• Clopidogrel
• Colchicine
• Cyclosporine
• dabigatran
• Dexamethasone
• Digoxin
• erythromycin
• estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
• “gliptin” Diabetes medications (e.g., Linagliptin, Saxagliptin, Sitagliptin)
• glucosamine
• Heparin
• herbal products that affect blood clotting (e.g., cat's claw, chamomile, fenugreek, evening primrose, feverfew, garlic, ginger, ginseng, turmeric)
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• Hydrocortisone
• Loperamide
• low molecular weight heparins (e.g., Dalteparin, Enoxaparin, Tinzaparin)
• Methotrexate
• multivitamin supplements
• non-steroidal anti-inflammatory medications (NSAIDs; e.g., Diclofenac, Ibuprofen, Naproxen)
• Ondansetron
• omega-3 fatty acids
• Paliperidone
• Pentoxifylline
• protein kinase inhibitors (e.g., Crizotinib, Dasatinib, imatinib, Nilotinib)
• Prucalopride
• quinidine
• quinine
• Ranitidine
• rifampin
• Risperidone
• Rivaroxaban
• Romidepsin
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• serotonin-norepinephrine reuptake inhibitors (SNRIs; Desvenlafaxine, Duloxetine, Venlafaxine)
• "statin" anti-cholesterol medications (e.g., Atorvastatin, Lovastatin, Simvastatin)
• Tacrolimus
• theophyllines (with injectable form of dipyridamole; Aminophylline, Theophylline)
• Ticagrelor
• Ticlopidine
• Tolvaptan
• vitamin E
• Warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Dipyridamole. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Dipyridamole.

Liver function: Liver disease or reduced liver function may cause Dipyridamole to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Dipyridamole may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Dipyridamole, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Dipyridamole.

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Low blood pressure: Dipyridamole may cause lowering of blood pressure and increase the effect of blood pressure-lowering medications.

Pregnancy: Dipyridamole should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Dipyridamole, contact your doctor immediately.

Breast-feeding: Dipyridamole passes into breast milk. If you are a breast-feeding mother and are taking dipyridamole, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.