Innohep

Innohep (Tinzaparin) is given by subcutaneous (under the skin) injection only. The dose of Innohep (Tinzaparin) varies according to individual circumstances, such as the condition being treated and body weight. Your doctor will choose the dose that is most likely to prevent or treat blood clots but not cause you to bleed easily.

To prevent complications from general surgery or hip surgery, you will receive your first injection of Innohep (Tinzaparin) about 2 hours before the surgery and once daily after that for 7 to 10 days. For knee surgery, you will receive your first dose after surgery and once daily for 7 to 10 days. To treat deep vein thrombosis and pulmonary embolism, you will receive your dose once daily until the doctor recommends stopping therapy.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

In some cases, you may need to use Innohep (Tinzaparin) injection at home, after you leave the hospital. If you need to give the injection to yourself, your doctor or nurse will show you how to use the ready-to-use prefilled syringes. Be sure to follow the instructions exactly. Ask any questions necessary to be sure you completely understand how to use the medication. Innohep (Tinzaparin) must not be injected into the muscle.

It is important to use Innohep (Tinzaparin) exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Innohep (Tinzaparin) prefilled syringes at room temperature and do not refrigerate. Cold solution may result in painful injection. Syringes are for single use only.

Protect Innohep (Tinzaparin) from light and moisture and keep it out of reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

In addition to its desired action, this medication may cause some adverse effects, notably: it may cause headaches; it may cause bruising at the injection site; it may cause nausea or, rarely, vomiting; it may cause nosebleeds. Each person may react differently to a treatment. If you think this medication may be causing adverse effects (including those described here, or others), talk to your health care professional. He or she can help you to determine whether or not the medication is the source of the problem.

Multi-dose Vials

10,000 anti-Xa IU/mL
Each mL of sterile solution contains 10,000 anti-Xa IU of Innohep (Tinzaparin) sodium. Nonmedicinal ingredients: benzyl alcohol, sodium hydroxide (quantity sufficient for pH adjustment), sodium metabisulfite, and water for injection. pH range of the final solution is 5.0 to 7.5.

20,000 anti-Xa IU/mL
Each mL of sterile solution contains 20,000 anti-Xa IU of Innohep (Tinzaparin) sodium. Nonmedicinal ingredients: benzyl alcohol, sodium hydroxide (quantity sufficient for pH adjustment), sodium metabisulfite, and water for injection. pH range of the final solution is 5.0 to 7.5.

Pre-filled Syringes

10,000 anti-Xa IU/mL (2500 IU, 3500 IU, 4500 IU syringes)
Each mL of sterile solution contains 10,000 anti-Xa IU of Innohep (Tinzaparin) sodium. Nonmedicinal ingredients: sodium acetate·3H2O, sodium hydroxide (quantity sufficient for pH adjustment), and water for injection. pH range of the final solution is 5.0 to 7.5. Preservative-free.

20,000 anti-Xa IU/mL (8000 IU, 10000 IU, 12000 IU, 14000 IU, 16000 IU, 18000 IU syringes)
Each mL of sterile solution contains Innohep (Tinzaparin) sodium 20,000 anti-Xa IU. Nonmedicinal ingredients: sodium metabisulfite, sodium hydroxide (quantity sufficient for pH adjustment), and water for injection. pH range of the final solution is 5.0 to 7.5. Preservative-free.

Do not use Innohep (Tinzaparin) if you:

• are allergic to Innohep (Tinzaparin) or any ingredients of the medication
• are allergic to low-molecular-weight heparins or Heparin
• are at risk of heparin-induced thrombocytopenia (decreased number of platelets often associated with increased bleeding)
• have a history of thrombocytopenia
• have a stomach or duodenal ulcer
• have acute or sub-acute bacterial Endocarditis (infection of the inner lining of the heart)
• have any conditions associated with increased risk of bleeding
• have bleeding inside the brain (brain hemorrhage)
• have diabetic or hemorrhagic retinopathy (damage to the back of the eye)
• have injuries or have just had an operation involving the brain, spinal cord, eyes, or ears
• have major blood clotting disorders (e.g., Hemophilia or idiopathic thrombocytopenic purpura)
• have severe uncontrolled high blood pressure
• are receiving spinal/epidural anesthesia and will be needing multiple high doses of Innohep (Tinzaparin)
• have tested positive on an in-vitro platelet aggregation test in the presence of Innohep (Tinzaparin)
• have uncontrollable bleeding

Do not use the multi-dose vials for children under 3 years of age.

There may be an interaction between Innohep (Tinzaparin) and any of the following:

• acetylsalicylic acid (Asa)
• Aliskiren
• angiotensin converting enzyme inhibitors (ACEIs; Captopril, Enalapril, Ramipril)
• angiotensin receptor blockers (ARBs; e.g., candasartan, Irbesartan, Losartan)
• Apixaban
• Canagliflozin
• Clopidogrel
• dabigatran
• Dasatinib
• Deferasirox
• Desvenlafaxine
• Dipyridamole
• Eplerenone
• estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
• feverfew
• garlic
• ginger
• ginkgo
• heparin
• Ibrutinib
• other low molecular weight heparins (e.g., Dalteparin, Enoxaparin, Innohep (Tinzaparin))
• Mesalamine
• nonsteroidal anti-inflammatory medications (NSAIDs; e.g., Diclofenac, Ibuprofen, Indomethacin, Naproxen)
• Obinutuzumab
• omega-3 fatty acids
• Pentoxifylline
• potassium sparing diuretics (water pills; e.g., Amiloride, Spironolactone)
• potassium supplements
• Prasugrel
• progestins (e.g., Dienogest, Levonorgestrel, medroxyprogesterone, Norethindrone)
• Rivaroxaban
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• Sulfasalazine
• Ticagrelor
• Ticlopidine
• tipranavir
• Venlafaxine
• vitamin E
• Warfarin

If you are taking any of these, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Innohep (Tinzaparin). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Innohep (Tinzaparin).

Blood clotting: Innohep (Tinzaparin) is intended to prevent unwanted blood clots, but it can also make you bleed more easily. You should take care when performing activities that increase your risk of bleeding. Tell your doctor of any signs that your blood is not clotting as quickly. Such symptoms may include black and tarry stools, blood in the urine, easy bruising, or cuts that won't stop bleeding. You will need to have regular blood tests while taking Innohep (Tinzaparin) to ensure that you are receiving the correct dose.

Body weight: The safety and effectiveness of Innohep (Tinzaparin) for people of high weight (e.g., over 120 kg) and low weight (e.g., under 45 kg) have not been fully established. If you have a high or low body weight, discuss with your doctor how Innohep (Tinzaparin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Innohep (Tinzaparin), and whether any special monitoring is needed.

Heart problems: There have been reports of blood clots in people with prosthetic valves using low molecular weight heparins. Pregnant women with prosthetic heart valves have an increased risk of thromboembolism. If you have prosthetic heart valves your doctor should closely monitor your condition while you are using Innohep (Tinzaparin).

Kidney Disease: People with decreased kidney function or kidney disease may experience increased side effects of Innohep (Tinzaparin) as a result of the medication building up in the body. If you have kidney disease, discuss with your doctor how Innohep (Tinzaparin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Innohep (Tinzaparin), and whether any special monitoring is needed. You will probably need to have regular blood tests to ensure your kidneys are working properly while you are using Innohep (Tinzaparin).

Liver disease: If you have liver disease, discuss with your doctor how Innohep (Tinzaparin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Innohep (Tinzaparin), and whether any special monitoring is needed. You will probably need to have regular tests to ensure your liver is working properly while you are using Innohep (Tinzaparin).

Potassium levels: Increases in blood levels of potassium occur for a small percentage of people taking medications in the heparin family, including Innohep (Tinzaparin). This may be more likely to happen if you have Diabetes or chronic kidney failure, or if you are taking potassium sparing diuretics. Your doctor may want to monitor your potassium levels. If you experience unexplained nausea, fatigue, muscle weakness, or tingling sensations, contact your doctor.

Stomach ulcers: If you have a history of stomach ulcers, discuss with your doctor how Innohep (Tinzaparin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Innohep (Tinzaparin), and whether any special monitoring is needed.

Pregnancy: The safety of Innohep (Tinzaparin) for use during pregnancy has not been established. Innohep (Tinzaparin) should not be used during pregnancy unless the benefits outweigh the risks. If your doctor recommends using Innohep (Tinzaparin), the multi-dose vial of Innohep (Tinzaparin) should not be used by pregnant women since it contains benzyl alcohol. If you become pregnant while taking Innohep (Tinzaparin), contact your doctor immediately.

Breast-feeding: It is not known if Innohep (Tinzaparin) passes into breast milk. If you are a breast-feeding mother and are taking Innohep (Tinzaparin), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Innohep (Tinzaparin) have not been established for children. Children under 3 years old must not receive Innohep (Tinzaparin) from multi-dose vials. The preservative, benzyl alcohol, may cause an effect called "gasping syndrome," which may be fatal to small children.

Seniors: Seniors may be at an increased risk of bleeding while using Innohep (Tinzaparin). Innohep (Tinzaparin) is not recommended in seniors over the age of 70 with decreased renal function and in those who have low body weight (<45 kg).

This product thins the blood and prevents blockage of blood vessels. It belongs to the family of low-molecular weight heparins.<br/><br/>It must be injected under the skin (subcutaneously) in the abdominal region, according to the technique you were shown. Be sure to choose a different injection site each time.<br/><br/>WARNING: If you injure yourself, prolonged bleeding may occur. Report any excessive or unusual bleeding to your doctor. To reduce the risk of bleeding, do not consume alcohol, make any significant dietary changes, or take acetylsalicylic acid (ASA, e.g., Aspirin) unless prescribed by your doctor.