Trajenta

The usual dose of Trajenta (Linagliptin) is 5 mg daily.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Trajenta (Linagliptin) can be taken with or without food.

It is important to take Trajenta (Linagliptin) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Trajenta (Linagliptin) at room temperature and keep it out of the reach of children.

What form(s) does Trajenta (Linagliptin) come in?

Each light red, round, biconvex, bevelled-edged, film-coated tablet, marked on one side with the Boehringer Ingelheim company symbol and "D5" on the other, contains 5 mg of Trajenta (Linagliptin). Nonmedicinal ingredients: mannitol, pregelatinised starch, maize starch, copovidone, and magnesium stearate; film coating: hypromellose, titanium dioxide, talc, macrogol, and iron oxide red.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

In addition to its desired action, this medication may cause some adverse effects, notably: it may cause headaches; it may increase your blood pressure; it may cause muscle pain. Each person may react differently to a treatment. If you think this medication may be causing adverse effects (including those described here, or others), talk to your health care professional. He or she can help you to determine whether or not the medication is the source of the problem.

Each light red, round, biconvex, bevelled-edged, film-coated tablet, marked on one side with the Boehringer Ingelheim company symbol and "D5" on the other, contains 5 mg of Trajenta (Linagliptin). Nonmedicinal ingredients: mannitol, pregelatinised starch, maize starch, copovidone, and magnesium stearate; film coating: hypromellose, titanium dioxide, talc, macrogol, and iron oxide red.

Do not take Trajenta (Linagliptin) if you:

• are allergic to Trajenta (Linagliptin) or any ingredients of Trajenta (Linagliptin)
• have ketoacidosis (a complication of diabetes associated with high blood sugar, weight loss, nausea, or vomiting)
• have Type 1 Diabetes

There may be an interaction between Trajenta (Linagliptin) and any of the following:

• acetylsalicylic acid (Asa)
• Amiodarone
• androgens (e.g., testosterone)
• angiotensin converting enzyme inhibitors (ACEIs; Captopril, Enalapril, Ramipril)
• Apalutamide
• atypical antipsychotics (e.g., Aripiprazole, Clozapine, Olanzapine, Quetiapine, Risperidone)
• "azole" antifungals (e.g., itraconazole, ketoconazole, Voriconazole)
• Basiliximab
• Bosentan
• Buserelin
• Carbamazepine
• Carvedilol
• chloroquine
• oral corticosteroids (e.g., Dexamethasone, Hydrocortisone, Prednisone)
• Cyclosporine
• Cyproterone
• Dabrafenib
• daclatasvir
• Danazol
• Deferasirox
• other diabetes medications (e.g., chlorpropamide, glyburide, insulin, metformin, Rosiglitazone)
• Disopyramide
• diuretics (e.g., Furosemide, Hydrochlorothiazide, Indapamide)
• Dronedarone
• Enzalutamide
• Elagolix
• Eliglustat
• Epinephrine
• Eslicarbazepine
• estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
• Everolimus
• Flibanserin
• glecaprevir and pibrentasvir
• Glucagon
• Goserelin
• HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., efavirenz, etravirine, nevirapine)
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• hydroxychloroquine
• Lanreotide
• Lapatinib
• ledipasvir
• Leuprolide
• lumacaftor and Ivacaftor
• macrolide antibiotics (e.g., azithromycin, clarithromycin, erythromycin)
• mifepristone
• Mitotane
• Modafinil
• monoamine oxidase inhibitors (M.O.S. e.g., Moclobemide, Phenelzine, Rasagiline, Selegiline, Tranylcypromine)
• Niacin
• Nilotinib
• Octreotide
• Pasireotide
• Pegvisomant
• Phenobarbital
• Phenytoin
• primidone
• progestins (e.g., Dienogest, Levonorgestrel, medroxyprogesterone, Norethindrone, Progesterone)
• Propafenone
• quinidine
• quinine
• quinolone antibiotics (e.g., ciprofloxacin, Norfloxacin, Ofloxacin)
• rifabutin
• rifampin
• St. John's wort
• Sarilumab
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• siltuximab
• Sirolimus
• Somatropin
• sulfonamide antibiotics ("sulfas"; e.g., sulfisoxazole, sulfamethoxazole)
• Sunitinib
• Tacrolimus
• Temsirolimus
• Tocilizumab
• Tramadol
• velpatasvir
• Venetoclax
• Verapamil
• Vorinostat

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Trajenta (Linagliptin). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking.

Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Trajenta (Linagliptin).

Blood sugar: Hypoglycemia (low blood sugar) can occur when Trajenta (Linagliptin) is used in combination with Metformin and a sulfonylurea (e.g., Glyburide, Gliclazide). Your doctor may suggest a lower dose of the sulfonylurea when you start Trajenta (Linagliptin).

If you experience low blood sugar (e.g., headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heartbeat, sweating, and feeling jittery) contact your doctor.

During times of stress (e.g., fever, trauma, surgery, infection), your doctor may suggest that you temporarily stop Trajenta (Linagliptin) and use insulin to help control your blood sugar levels.

Congestive Heart Failure and heart disease: Heart failure has occurred for people taking medications similar to Trajenta (Linagliptin). If you have CHF or heart disease, discuss with your doctor how Trajenta (Linagliptin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Trajenta (Linagliptin), and whether Trajenta (Linagliptin) is appropriate for you.

Immune system: Trajenta (Linagliptin) can reduce the number of cells that fight infection in the body (white blood cells). This side effect may be more of a concern for people who already have a weakened immune system due to certain medical conditions or medications. If this applies to you, discuss with your doctor how Trajenta (Linagliptin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Trajenta (Linagliptin), and whether any special monitoring is needed.

Kidney function: There is limited information about the safety and effectiveness of the use of Trajenta (Linagliptin) by people with severely reduced kidney function. If you have reduced kidney function or Kidney Disease, discuss with your doctor how Trajenta (Linagliptin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Trajenta (Linagliptin), and whether any special monitoring is needed.

Trajenta (Linagliptin) is not recommended if you have severely reduced kidney function.

Liver function: There is limited information about the safety and effectiveness of Trajenta (Linagliptin) when it is used by people with reduced liver function. If you have reduced liver function or liver disease, discuss with your doctor how Trajenta (Linagliptin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Trajenta (Linagliptin), and whether any special monitoring is needed. Trajenta (Linagliptin) is not recommended if you have severely reduced liver function.

Pancreatitis: Trajenta (Linagliptin) may cause or worsen pancreatitis (inflammation of the pancreas). If you have a history of pancreatitis, gallstones, Alcoholism, or high triglycerides, you may be more at risk of experiencing this and should be closely monitored by your doctor while taking Trajenta (Linagliptin).

If you experience symptoms of pancreatitis (e.g., upper left abdominal pain, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen or prolonged and severe abdominal pain with or without vomiting), contact your doctor immediately.

Pregnancy: Trajenta (Linagliptin) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Trajenta (Linagliptin), contact your doctor immediately.

Breast-feeding: It is not known if Trajenta (Linagliptin) passes into breast milk. If you are a breast-feeding mother and are taking Trajenta (Linagliptin), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Trajenta (Linagliptin) have not been established for children.

Seniors: There is limited information about the safety and effectiveness of Trajenta (Linagliptin) for people 75 years and older. Seniors may be more likely to experience side effects of Trajenta (Linagliptin).

This medication is typically used only once a day. However, your pharmacist may have suggested a different schedule that is more appropriate for you. It must be used regularly and continuously to maintain its beneficial effects. Be sure to keep an adequate supply on hand. Like all individuals with diabetes, you should monitor your blood sugar levels regularly using the appropriate device. If you remember missing a dose within 12 hours of the time it is usually taken, take it as soon as you remember, then take the next dose at the regularly scheduled time. If the dose is missed by more than 12 hours, skip the missed dose. Do not double the next dose to catch up. This medication may be taken with or without food.