Lozide

The recommended starting dose of Lozide (Indapamide) is 1.25 mg once daily in the morning. After 4 to 8 weeks, your doctor may increase this to 2.5 mg once daily, depending on the effect of the medication. If a dose of 2.5 mg daily does not reduce your blood pressure sufficiently, your doctor will likely add another blood-pressure-lowering medication that is not a diuretic or may try a different diuretic. Do not take more than 2.5 mg daily.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Lozide (Indapamide) exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Lozide (Indapamide) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

In addition to its desired action, this medication may cause some adverse effects, notably: it may decrease your appetite; it may cause headaches; it may cause dizziness - use caution when getting up from a lying or sitting position and use caution if driving; it may cause nausea or, rarely, vomiting; it may make your skin more sensitive to UV rays (e.g., sunlight, tanning lamps) - avoid exposure to UV rays as much as possible and protect yourself when out in the sun. Each person may react differently to a treatment. If you think this medication may be causing adverse effects (including those described here, or others), talk to your health care professional. He or she can help you to determine whether or not the medication is the source of the problem.

1.25 mg
Each round, orange, film-coated tablet, with "S" marked on one side, contains Lozide (Indapamide) 1.25 mg. Nonmedicinal ingredients: glycerol, hydroxypropyl methylcellulose, lactose monohydrate, macrogol 6000, magnesium stearate, maize starch, microcrystalline cellulose, pregelatinized starch, sunset yellow S Aluminium Lake, talc, and titanium dioxide.

2.5 mg
Each pink, sugar-coated tablet contains Lozide (Indapamide) 2.5 mg. Nonmedicinal ingredients: colloidal silica, corn starch, ethylcellulose, FD&C Red No. 3 Lake, FD&C Yellow No. 6 Lake, glycerol monooleate, lactose, magnesium stearate, polysorbate, povidone, pregelatinized corn starch, sodium benzoate, sodium carboxymethylcellulose, sucrose, talc, titanium dioxide, and white beeswax.

Do not take Lozide (Indapamide) if you:

• are allergic to Lozide (Indapamide) or any ingredients of Lozide (Indapamide)
• are allergic to sulfa (sulfonamide) medications (e.g., sulfamethoxazole)
• are breast-feeding
• are pregnant
• are taking certain medications that can increase the risk of a type of abnormal heart rhythm called torsades de pointes
• have low levels of potassium in your blood
• have severe kidney failure
• have severe liver impairment, including possible brain involvement
• have lactose or galactose intolerance or malabsorption

There may be an interaction between Lozide (Indapamide) and any of the following:

• aclidinium
• alcohol
• Aldesleukin
• Aliskiren
• Allopurinol
• alpha-agonists (e.g., Clonidine, methyldopa)
• alpha-blockers (e.g., Alfuzosin, Doxazosin, Tamsulosin)
• amifostine
• Amiodarone
• amphetamines (e.g., Dextroamphetamine, Lisdexamfetamine)
• angiotensin converting enzyme inhibitors (ACEIs; e.g., Captopril, Lisinopril, Ramipril)
• angiotensin receptor blockers (ARBs; e.g., Candesartan, Irbesartan, Losartan)
• antihistamines (e.g., cetirizine, doxylamine, Diphenhydramine, Hydroxyzine, Loratadine)
• antipsychotics (e.g., chlorpromazine, Clozapine, Haloperidol, Olanzapine, Quetiapine, Risperidone)
• atropine
• azelastine
• Baclofen
• barbiturates (e.g., butalbital, Phenobarbital)
• belladonna
• Benztropine
• beta2-agonists (e.g., formoterol, Indacaterol, salbutamol)
• beta-adrenergic blockers (e.g., Atenolol, Propranolol, sotalol)
• brimonidine
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
• calcium supplements (e.g., calcium carbonate, calcium citrate)
• Carbamazepine
• Cholestyramine
• Colestipol
• inhaled corticosteroids (e.g., budesonide, ciclesonide, fluticasone)
• oral corticosteroids (e.g., Dexamethasone, Hydrocortisone, Prednisone)
• Cyclobenzaprine
• Cyclophosphamide
• dexmethylphenidate
• diabetes medications (e.g., chlorpropamide, Glyburide, insulin, Metformin, Rosiglitazone)
• diazoxide
• Digoxin
• Disopyramide
• diuretics water pills; e.g., Furosemide, Hydrochlorothiazide, triamterene)
• dofetilide
• Dronedarone
• Duloxetine
• Flavoxate
• Flecainide
• glycopyrrolate
• ipratropium
• ketotifen
• levodopa
• licorice
• lithium
• Methadone
• Methylphenidate
• mifepristone
• Minoxidil
• monoamine oxidase inhibitors (M.O.S. e.g., Moclobemide, Phenelzine, Rasagiline, Selegiline, Tranylcypromine)
• multiple vitamins/minerals
• narcotic pain relievers (e.g., Codeine, Fentanyl, Morphine, Oxycodone)
• nitrates (e.g., Nitroglycerin, isosorbide dinitrate, isosorbide mononitrate)
• nonsteroidal anti-inflammatory medications (NSAIDs; e.g., Ibuprofen, Ketorolac, Naproxen)
• Obinutuzumab
• orphenadrine
• Oxcarbazepine
• Oxybutynin
• Pentoxifylline
• phosphodiesterase 5 inhibitors (e.g., Sildenafil, Tadalafil, Vardenafil)
• Porfimer
• quinidine
• quinine
• scopolamine
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• sodium phosphates
• Solifenacin
• tiotropium
• Tolterodine
• Topiramate
• Tramadol
• Trazodone
• tricyclic antidepressants (e.g., Amitriptyline, Clomipramine, Desipramine)
• umeclidinium
• vitamin D analogues (e.g., alfacalcidol, Calcitriol, cholecalciferol)
• Yohimbine

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Lozide (Indapamide). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Lozide (Indapamide).

Abnormal heart rhythms: Lozide (Indapamide) can cause abnormal heart rhythms. Certain medications (e.g., Sotalol, quinidine, thioridazine, Chlorpromazine, Pimozide, moxifloxacin, Mefloquine, pentamidine, arsenic trioxide, probucol, Tacrolimus) can increase the risk of a type of abnormal heart rhythm called torsades de pointes and should be used with caution with Lozide (Indapamide).

If you are taking medication for abnormal heart rhythms, discuss with your doctor how Lozide (Indapamide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Lozide (Indapamide), and whether any special monitoring is needed.

Allergy: Some people who are allergic to sulfonamides also experience allergic reactions to Lozide (Indapamide), as it has a sulfonamide component. Before you take Lozide (Indapamide), tell your doctor about any previous adverse reactions you have had to medications, especially sulfonamide (sulfa) antibiotics. Contact your doctor at once if you experience signs of an allergic reaction, such as skin rash, itching, difficulty breathing, or swelling of the face and throat.

Diabetes: Although Lozide (Indapamide) has very little effect on blood sugar control, people with diabetes may need additional insulin to keep blood sugar levels steady. High blood sugar and sugar in the urine may occur for people who have risk factors for developing diabetes.

If you have diabetes, or are at risk for developing diabetes, discuss with your doctor how Lozide (Indapamide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Lozide (Indapamide), and whether any special monitoring is needed.

Dizziness: Lozide (Indapamide) can cause severe dizziness, especially when rising from a sitting or lying position. This is more likely to occur when starting to take Lozide (Indapamide) or increasing the dose being taken, particularly when other medications with similar side effects are being taken. If you are taking medications that can cause dizziness, rise slowly from sitting or lying down to reduce the possibility of severe dizziness or fainting.

Electrolytes: Changes in the blood levels of electrolytes such as potassium and magnesium become severe at doses above 2.5 mg per day. Do not take more than 2.5 mg per day.

Abnormally low blood potassium levels may occur at all doses causing weakness, cramps, and abnormal heart rhythms. The warning signs of electrolyte imbalance are:

• drowsiness
• dry mouth
• frequent urination
• Low Blood Pressure
• muscle fatigue
• muscle pains or cramps
• racing heartbeat
• restlessness
• stomach problems (e.g., nausea, vomiting)
• thirst
• tiredness
• weakness

Galactose intolerance: Lozide (Indapamide) medications are prepared with lactose. If you have lactose or galactose intolerance you should not take these medications.

Gout: Lozide (Indapamide) may increase the level of uric acid in the body. If you develop painful, warm and swollen joints contact your doctor as soon as possible. If you have a history of gout, discuss with your doctor how Lozide (Indapamide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Lozide (Indapamide), and whether any special monitoring is needed.

Kidney function: Lozide (Indapamide) is not helpful for people with severely reduced kidney function. If you have Kidney Disease or reduced kidney function, discuss with your doctor how Lozide (Indapamide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Lozide (Indapamide), and whether any special monitoring is needed. If you experience a decrease in the amount of urine your body is producing, contact your doctor as soon as possible.

Liver function: If you have liver disease or reduced liver function, discuss with your doctor how Lozide (Indapamide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Lozide (Indapamide), and whether any special monitoring is needed.

If you have severely reduced liver function you should not take Lozide (Indapamide) because this increases the risk for developing liver-caused brain disease.

Sun sensitivity: Like other sulfonamide medications, Lozide (Indapamide) may cause increased sensitivity to the effects of exposure to the sun. If you experience a severe sunburn-like reaction while taking Lozide (Indapamide), contact your doctor immediately. Regardless, you should take measures to protect yourself from the sun, such as use of an appropriate sunscreen and keeping exposed skin covered, while taking Lozide (Indapamide).

Systemic Lupus erythematosus: Lozide (Indapamide) can worsen or activate the symptoms of lupus. If you experience swollen and painful joints, fever, fatigue, or rash on the nose and cheeks while taking Lozide (Indapamide), contact your doctor.

Pregnancy: In general, diuretics should not be used during pregnancy, due to the risk of reducing the growth of the fetus. Lozide (Indapamide) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Lozide (Indapamide), contact your doctor immediately.

Breast-feeding: Lozide (Indapamide) passes into breast milk. If you are a breast-feeding mother and are taking Lozide (Indapamide), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of Lozide (Indapamide) for use by children have not been established.

Seniors: Seniors may be at an increased risk of developing side effects to Lozide (Indapamide). Lower doses may be appropriate when using Lozide (Indapamide) to treat high blood pressure for seniors.

This medication is typically used only once a day. However, your pharmacist may have suggested a different schedule that is more appropriate for you. Important: Follow the instructions on the label. Do not use more of this product, or more often, than prescribed. It must be used regularly and continuously to maintain its beneficial effects. Be sure to keep an adequate supply on hand. If you forget a dose, take it as soon as you remember -- unless it is almost time for your next dose. In that case, skip the missed dose. Do not double the next dose to catch up. This medication may be taken with or without food. Consuming alcohol may modify the effect of this product. Limit alcohol consumption during treatment.