Detrol La

The usual recommended dose of Detrol LA (Tolterodine) extended-release capsules is 4 mg once daily to start. The dose may later be reduced to 2 mg once daily based on individual response and needs. The maximum dose is 4 mg daily.

For people with reduced liver or kidney function, and people taking certain medications, the recommended dose is 2 mg once daily. Check with your doctor or pharmacist.

The capsules should be swallowed whole, not crushed or chewed. They can be taken with or without food.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important to take Detrol LA (Tolterodine) regularly and exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Detrol LA (Tolterodine) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

In addition to its desired action, this medication may cause some adverse effects, notably: it may cause dryness of the mouth; it may cause headaches; it may cause constipation - to prevent this, drink plenty of water or juice, and eat more dietary fibre; it may cause drowsiness or dizziness - use caution when getting up from a lying or sitting position and use caution if driving; it may cause vision problems. Each person may react differently to a treatment. If you think this medication may be causing adverse effects (including those described here, or others), talk to your health care professional. He or she can help you to determine whether or not the medication is the source of the problem.

2 mg
Each blue-green extended release capsule, with a symbol and "2" printed in white ink, contains Detrol LA (Tolterodine) L-tartrate 2 mg. Nonmedicinal ingredients: ammonium hydroxide, ethylcellulose, FD&C Blue No. 2, gelatin, hypromellose, medium chain triglycerides, oleic acid, Opacode White S-1-7085 (shellac glaze, titanium dioxide, ammonium hydroxide, propylene glycol, and simethicone), starch, sucrose, and yellow iron oxide.

4 mg
Each blue extended release capsule, with symbol and "4" printed in white ink, contains Detrol LA (Tolterodine) L-tartrate 4 mg. Nonmedicinal ingredients: ammonium hydroxide, ethylcellulose, FD&C Blue No. 2, gelatin, hypromellose, medium chain triglycerides, oleic acid, Opacode White S-1-7085 (shellac glaze, titanium dioxide, ammonium hydroxide, propylene glycol, and simethicone), starch, and sucrose.

Detrol LA (Tolterodine) should not be taken by anyone who:

• is allergic to Detrol LA (Tolterodine) or any of the ingredients of the medication
• has gastric retention (stomach obstruction)
• has uncontrolled narrow-angle Glaucoma
• has urinary retention

There may be an interaction between Detrol LA (Tolterodine) and any of the following:

• Abiraterone
• aclidinium
• alcohol
• Amiodarone
• antihistamines (e.g,. cetirizine, doxylamine, Diphenhydramine, Hydroxyzine, Loratadine)
• antipsychotics (e.g., Chlorpromazine, Clozapine, Haloperidol, Olanzapine, Quetiapine, Risperidone)
• Aprepitant
• atropine
• azelastine
• "azole" antifungals (e.g., ketoconazole, fluconazole, Voriconazole)
• Bicalutamide
• belladonna
• Benztropine
• boceprevir
• Bosentan
• Bupropion
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
• Carbamazepine
• chloroquine
• Cinacalcet
• Clobazam
• cocaine
• conivaptan
• Cyclobenzaprine
• Cyclosporine
• Disopyramide
• Domperidone
• Donepezil
• Dronedarone
• Duloxetine
• Enzalutamide
• Flavoxate
• Flecainide
• Fluoxetine
• formoterol
• Galantamine
• glycopyrrolate
• grapefruit juice
• HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delaviridine, efavirenz, etravirine, nevirapine)
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• ipratropium
• isoniazid
• ketotifen
• Lomitapide
• macrolide antibiotics (e.g., erythromycin, clarithromycin, telithromycin)
• Methadone
• Metoclopramide
• mifepristone

• Mirabegron
• Mitotane
• Metronidazole
• Modafinil
• narcotic pain relievers (e.g., Codeine, Fentanyl, Morphine, Oxycodone)
• nefazodone
• Norfloxacin
• orphenadrine
• Oxybutynin
• peginterferon alfa-2b
• Phenobarbital
• Phenytoin
• Pimozide
• potassium chloride
• Primaquine
• primidone
• procainamide
• quinidine
• quinine
• quinolone antibiotics (e.g., ciprofloxacin, Ofloxacin,)
• rifabutin
• rifampin
• rilpivirine
• Rivastigmine
• St. John's wort
• secretin
• serotonin antagonists (anti-emetics; Dolasetron, Granisetron, Ondansetron)
• certain selective serotonin reuptake inhibitors (SSRIs; e.g., duloxetine, fluoxetine, Paroxetine, Sertraline)
• scopolamine
• simeprevir
• sitaxentan
• Sotalol
• Stiripentol
• telaprevir
• terbinafine
• Tetrabenazine
• Tetracycline
• thiazide diuretics (water pills; e.g., Hydrochlorothiazide, Indapamide, Metolazone)
• Ticlopidine
• tiotropium
• Tocilizumab
• Topiramate
• Tranylcypromine
• Trazodone
• tricyclic antidepressants (e.g., Amitriptyline, Clomipramine, Desipramine, Trimipramine)
• Triptorelin
• tyrosine kinase inhibitors (e.g., Lapatinib, Pazopanib, Sunitinib)
• Vinblastine
• Warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. In many cases, interactions are intended or are managed by close monitoring. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you being using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Abnormal heart rhythm: Detrol LA (Tolterodine) may cause or increase the risk for a certain type of abnormal heart rhythm called QT prolongation. Other medications can also increase the risk of QT prolongation when taken together with Detrol LA (Tolterodine). This abnormal heart rhythm is more likely to occur in women, seniors, and people with certain risk factors such as:

• heart disease
• other heart rhythm problems (such as atrial fibrillation)
• a history of Stroke
• a family history of sudden cardiac death
• blood electrolyte disturbances
• abnormally slow heartbeat
• Eating Disorders
• Diabetes
• nerve disorders

If you experience symptoms of an abnormal heart rhythm such as dizziness, heart palpitations (fast, pounding, or irregular heartbeat), fainting, or seizures, stop taking Detrol LA (Tolterodine) and get immediate medical attention.

Bladder problems: People with conditions that significantly block the bladder should be closely monitored by their doctor for urinary retention while taking Detrol LA (Tolterodine). If you experience difficulty urinating while taking Detrol LA (Tolterodine), contact your doctor.

Driving/using machinery: Detrol LA (Tolterodine) may cause fatigue, dizziness, or blurred vision. Avoid activities requiring mental alertness, such as driving, operating machinery, or performing hazardous work, if the medication affects you in this way.

Drowsiness/reduced alertness: Detrol LA (Tolterodine) may cause dizziness, which may impair your ability to drive or operate machinery. Avoid hazardous tasks until you know how the medication affects you.

Glaucoma: People who have controlled narrow-angle glaucoma should discuss the benefits and risks of Detrol LA (Tolterodine) with their doctor. Detrol LA (Tolterodine) may worsen this condition.

Kidney function: Kidney Disease or reduced kidney function may cause Detrol LA (Tolterodine) to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how Detrol LA (Tolterodine) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Detrol LA (Tolterodine), and whether any special monitoring is needed.

Liver function: People with liver disease may be more at risk of experiencing side effects and may require lower doses of Detrol LA (Tolterodine). Liver disease or reduced liver function may cause Detrol LA (Tolterodine) to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Detrol LA (Tolterodine) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Detrol LA (Tolterodine), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Detrol LA (Tolterodine).

Myasthenia Gravis: If you have myasthenia gravis, Detrol LA (Tolterodine) may make your symptoms worse. Discuss with your doctor how Detrol LA (Tolterodine) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Detrol LA (Tolterodine), and whether any special monitoring is needed.

Stomach problems: People with stomach problems affecting the passage and digestion of food should discuss with their doctor how Detrol LA (Tolterodine) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Detrol LA (Tolterodine), and whether any special monitoring is needed.

Pregnancy: Detrol LA (Tolterodine) should not be used during pregnancy unless the benefits outweigh the risks. If you are or may be pregnant, talk to your doctor about the benefits and risks of using this medication. Women who may become pregnant should use adequate contraception (birth control) while taking Detrol LA (Tolterodine).

Breast-feeding: It is not known if Detrol LA (Tolterodine) passes into breast milk. If you are a breast-feeding mother and are taking Detrol LA (Tolterodine), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Detrol LA (Tolterodine) have not been established for children.

This medication is typically used only once a day. However, your pharmacist may have suggested a different schedule that is more appropriate for you. Take it regularly and continuously to maintain its beneficial effects. Important: Follow the instructions on the label. Do not use more of this product, or more often, than prescribed. The capsule of this medication should not be opened, crushed or chewed. If you forget a dose, take it as soon as you remember -- unless it is almost time for your next dose. In that case, skip the missed dose. Do not double the next dose to catch up. This medication may be taken with or without food.