Domperidone

The usual adult dose of domperidone is 10 mg, taken 15 to 30 minutes before meals. The maximum recommended dose is a total of 30 mg daily for the shortest possible duration of treatment. Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that Domperidone be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Domperidone at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

In addition to its desired action, this medication may cause some adverse effects, notably: it may cause dryness of the mouth; it may cause headaches. Each person may react differently to a treatment. If you think this medication may be causing adverse effects (including those described here, or others), talk to your health care professional. He or she can help you to determine whether or not the medication is the source of the problem.

Each white, plain-coated, round, biconvex tablet, engraved with "rph D51" on one side and plain on the other, contains 12.72 mg of domperidone maleate (equivalent to 10 mg of domperidone). Nonmedicinal ingredients: cornstarch, croscarmelose sodium, hydroxypropyl methylcellulose, lactose, magnesium stearate, microcrystalline cellulose, polydextrose, polyethylene glycol, povidone, sodium docusate 85%-sodium benzoate 15%, titanium dioxide, and triacetin.

Do not take domperidone if you:

• are allergic to domperidone or any ingredients of the medication
• are taking the medications in the same families as ketoconazole, erythromycin, ritonavir, or nefazodone
• are taking medications which cause QT prolongation
• have bleeding in the stomach or intestines
• have a blockage in the stomach or intestines
• have breaks in the lining of the stomach or intestines
• have a prolactinoma (a tumour of the pituitary gland)
• have uncorrected levels of potassium, magnesium, or calcium in your blood
• have cardiac disease (e.g., heart failure)
• have QT prolongation (a type of irregular heartbeat)
• have moderate or severe liver impairment

There may be an interaction between domperidone and any of the following:

• Alfuzosin
• amantadine
• Amiodarone
• anticholinergics (e.g., Benztropine, , oxybutinin)
• antihistamines (e.g., cetirizine, doxylamine, Diphenhydramine, Hydroxyzine, Loratadine)
• antipsychotic medications (e.g., Haloperidol, Risperidone, Quetiapine)
• Apomorphine
• Aprepitant
• "azole" antifungals (e.g., fluconazole, itraconazole, ketoconazole, Voriconazole)
• Buprenorphine
• Buserelin
• Capecitabine
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
• Ceritinib
• chloral hydrate
• chloroquine
• Cobicistat
• conivaptan
• Crizotinib
• Cyclosporine
• Degarelix
• Disopyramide
• Donepezil
• Doxepin
• Dronedarone
• Famotidine
• Fingolimod
• Flecainide
• formoterol
• Galantamine
• grapefruit juice
• HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, etravirine, nevirapine)
• HIV protease inhibitors (e.g., indinavir, atazanavir, lopinavir, nelfinavir, ritonavir)
• hydroxychloroquine
• Indacaterol
• Indapamide
• Ivabradine
• lithium
• Lomitapide
• Loperamide
• macrolide antibiotics (e.g., azithromycin, clarithromycin, erythromycin)
• Maprotiline
• mefloquine
• Methadone
• Metoclopramide
• Metronidazole
• mifepristone
• Mirabegron
• Mirtazapine
• monoamine oxidase inhibitors (M.O.S. e.g., Moclobemide, Phenelzine, Rasagiline, Selegiline, Tranylcypromine, nefazodone)
• Octreotide
• olodaterol
• pentamidine
• Primaquine
• probucol
• procainamide
• Propafenone
• protein kinase inhibitors (e.g., Bosutinib, Dasatinib, Erlotinib, imatinib, Nilotinib)
• Romidepsin
• quinidine
• quinine
• quinolone antibiotics (e.g., ciprofloxacin, moxifloxacin, Norfloxacin, levofloxacin)
• salmeterol
• selective serotonin reuptake inhibitors (SSRIS; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• serotonin antagonists (anti-emetic medications; e.g., Granisetron, ondansetron)
• simeprevir
• Solifenacin
• sotalol
• Stiripentol
• sulfamethoxazole
• tacrolimus
• Tamoxifen
• Tetrabenazine
• Trazodone
• tricyclic antidepressants (e.g., Amitriptyline, Nortriptyline)
• Trimethoprim
• Vardenafil
• Venlafaxine
• vilanterol
• Vorinostat

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Domperidone. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Domperidone.

Heart rhythm problems and cardiac arrest: Recent studies have shown that the risk of serious abnormal heart rhythms or cardiac arrest (sudden death) may be higher in people who take more than 30 mg of domperidone per day, or in people who are over 60 years of age. If you have a heart condition with abnormal electrical activity of your heart (e.g., QT prolongation), heart failure, or low blood levels of magnesium or potassium, discuss with your doctor how Domperidone may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Domperidone, and whether any special monitoring is needed.

This is especially important if you are taking other medications that can change the electrical activity of the heart or increase the amount of domperidone in your blood. Certain medications (e.g., Sotalol, quinidine, thioridazine, Chlorpromazine, Pimozide, moxifloxacin, Mefloquine, pentamidine, arsenic trioxide, Ondansetron, probucol, Tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should not be used in combination with domperidone if possible. You are more at risk for this type of abnormal heart rhythm and its complications if you:

• are female
• are older than 65 years of age
• have a family history of sudden cardiac death
• have a history of heart disease or abnormal heart rhythms
• have a slow heart rate
• have congenital prolongation of the QT interval
• have diabetes
• have had a Stroke
• have low potassium, magnesium, or calcium levels
• have nutritional deficiencies

Hormone levels: Domperidone may increase prolactin, a hormone in the body. If you have a history of Breast Cancer, ask your doctor about the benefits and risks associated with using Domperidone, since some breast cancers are thought to be prolactin-dependent.

Kidney function: Reduced kidney function may cause Domperidone to build up in the body, causing side effects. If you have reduced kidney function, discuss with your doctor how Domperidone may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Domperidone, and whether any special monitoring is needed. Your doctor may suggest a lower dose or that you take Domperidone only once or twice a day.

Liver function: Liver disease or reduced liver function may cause Domperidone to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Domperidone may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Domperidone, and whether any special monitoring is needed.

Pregnancy: Domperidone should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Domperidone, contact your doctor immediately.

Breast-feeding: Domperidone passes into breast milk. If you are a breast-feeding mother and are taking domperidone, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Domperidone have not been established for children.

Seniors: People over the age of 60 appear to be more likely to experience heart problems including Heart Attack with the use of domperidone. Talk to your doctor about the risks and benefits of taking Domperidone.

This medication is typically used 3 times a day. However, your pharmacist may have suggested a different schedule that is more appropriate for you. Take it regularly and continuously to maintain its beneficial effects. Important: Follow the instructions on the label. Do not use more of this product, or more often, than prescribed. This medication should be taken 30 minutes before a meal. Avoid grapefruit and grapefruit juice during your treatment. Grapefruit can seriously affect how this medication works.