Myrbetriq

The usual starting dose of Myrbetriq (Mirabegron) is 25 mg once daily. Your doctor may increase the dose to a maximum of 50 mg once daily, if necessary to control symptoms. Myrbetriq (Mirabegron) may be taken with or without food. Swallow the tablet whole with some water. Do not chew, crush, or divide the tablet.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important to take Myrbetriq (Mirabegron) exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. If you miss several doses, talk to your doctor. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Myrbetriq (Mirabegron) at room temperature and keep it out of reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

In addition to its desired action, this medication may cause some adverse effects, notably: it may cause dryness of the mouth; it may cause headaches; it may cause dizziness - use caution when getting up from a lying or sitting position and use caution if driving; it could make you more prone to urinary tract infections; it may increase your blood pressure; it may cause flu-like symptoms. Each person may react differently to a treatment. If you think this medication may be causing adverse effects (including those described here, or others), talk to your health care professional. He or she can help you to determine whether or not the medication is the source of the problem.

25 mg
Each oval, brown, film-coated, extended-release tablet debossed with "325" and the Astellas logo, contains 25 mg Myrbetriq (Mirabegron). Non-medicinal ingredients: polyethylene oxide, polyethylene glycol, hydroxypropyl cellulose, butylated hydroxytoluene, magnesium stearate, hypromellose, yellow ferric oxide, and red ferric oxide.

50 mg
Each oval, yellow, film-coated, extended-release tablet debossed with "355" and the Astellas logo, contains 50 mg Myrbetriq (Mirabegron). Non-medicinal ingredients: polyethylene oxide, polyethylene glycol, hydroxypropyl cellulose, butylated hydroxytoluene, magnesium stearate, hypromellose, and yellow ferric oxide.

Do not use Myrbetriq (Mirabegron) if you:

• are allergic to Myrbetriq (Mirabegron) or any ingredients of the medication
• are pregnant
• have severe, uncontrolled hypertension (high blood pressure)

There may be an interaction between Myrbetriq (Mirabegron) and any of the following:

• aclidinium
• Alfuzosin
• Amiodarone
• antihistamines (e.g., cetirizine, doxylamine, Diphenhydramine, Hydroxyzine, Loratadine)
• antipsychotics (e.g., chlorpromazine, Clozapine, pimozide, Haloperidol, Quetiapine, Ziprasidone)
• Atomoxetine
• atropine
• azelastine
• belladonna
• Benztropine
• beta-2 agonists (e.g., formoterol, salbutamol, salmeterol)
• beta-blockers (e.g., Carvedilol, Propranolol, Metoprolol, Timolol)
• Captopril
• chloroquine
• Cyclobenzaprine
• Darifenacin
• Dextromethorphan
• Digoxin
• Disopyramide
• dofetilide
• Domperidone
• Doxorubicin
• Dronedarone
• Eliglustat
• Fesoterodine
• Flavoxate
• Flecainide
• glycopyrrolate
• ipratropium
• ketotifen
• Lomitapide
• lopinavir
• macrolide antibiotics (e.g., clarithromycin, erythromycin)
• Maprotiline
• methamphetamine
• Mexiletine
• mifepristone
• Mirtazapine
• nefazodone
• certain opioids (e.g., Codeine, Hydrocodone, Methadone)
• orphenadrine
• Oxybutynin
• procainamide
• Propafenone
• quinidine
• quinine
• quinolone antibiotics (e.g., ciprofloxacin, levofloxacin)
• rifampin
• saquinavir
• scopolamine
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• serotonin antagonists (e.g., , Ondansetron, Granisetron)
• serotonin norepinephrine reuptake inhibitors (SNRIs: e.g., Desvenlafaxine, Duloxetine, Venlafaxine)
• Solifenacin
• tacrolimus
• Tamoxifen
• Tetrabenazine
• tiotropium
• Tolterodine
• Tramadol
• Tranylcypromine
• Trazodone
• tricyclic antidepressants (e.g., Amitriptyline, Clomipramine, Desipramine, Trimipramine)
• tyrosine kinase inhibitors (e.g., Lapatinib, Nilotinib, Sunitinib)
• umeclidinium

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Myrbetriq (Mirabegron). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take Myrbetriq (Mirabegron).

Abnormal heart rhythms: Myrbetriq (Mirabegron) can cause abnormal heart rhythms. Certain medications (e.g., Sotalol, quinidine, thioridazine, Chlorpromazine, Pimozide, moxifloxacin, Mefloquine, pentamidine, arsenic trioxide, probucol, Tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should not be used in combination with Myrbetriq (Mirabegron). You are more at risk for this type of abnormal heart rhythm and its complications if you:

• are female
• are older than 65 years of age
• have a family history of sudden cardiac death
• have a history of heart disease or abnormal heart rhythms
• have a slow heart rate
• have congenital prolongation of the QT interval
• have Diabetes
• have had a stroke
• have low potassium, magnesium, or calcium levels
• have nutritional deficiencies

If you have heart disease and abnormal heart rhythms, or are taking certain medications (e.g., Verapamil, atazanavir), discuss with your doctor how Myrbetriq (Mirabegron) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Myrbetriq (Mirabegron), and whether any special monitoring is needed.

Bladder obstruction: If you have bladder obstruction (blockage) or are taking any other medications, such as anticholinergics, for the treatment of overactive bladder, discuss with your doctor how Myrbetriq (Mirabegron) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Myrbetriq (Mirabegron), and whether any special monitoring is needed.

Glaucoma: If you have glaucoma, discuss with your doctor how Myrbetriq (Mirabegron) may affect your medical condition, and how your medical condition may affect the dosing and effectiveness of Myrbetriq (Mirabegron). Your doctor should perform regular eye exams while you are taking Myrbetriq (Mirabegron).

Heart conditions: Myrbetriq (Mirabegron) may cause increased blood pressure, or an increased heart rate. If you have a history of high blood pressure or heart disease, discuss with your doctor how Myrbetriq (Mirabegron) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Myrbetriq (Mirabegron), and whether any special monitoring is needed.

Kidney function: Kidney Disease or decreased kidney function may cause Myrbetriq (Mirabegron) to build up in the body, causing side effects. If you have reduced kidney function, discuss with your doctor how Myrbetriq (Mirabegron) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Myrbetriq (Mirabegron), and whether any special monitoring is needed.

Liver function: Liver disease or decreased liver function may cause Myrbetriq (Mirabegron) to build up in the body, causing side effects. If you have reduced liver function, discuss with your doctor how Myrbetriq (Mirabegron) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Myrbetriq (Mirabegron), and whether any special monitoring is needed.

Pregnancy: Myrbetriq (Mirabegron) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Myrbetriq (Mirabegron), contact your doctor immediately.

Breast-feeding: It is not known if Myrbetriq (Mirabegron) passes into breast milk. If you are a breast-feeding mother and are taking Myrbetriq (Mirabegron), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Myrbetriq (Mirabegron) have not been established for children under the age of 18.

This medication is typically used only once a day. However, your pharmacist may have suggested a different schedule that is more appropriate for you. Take it regularly and continuously to maintain its beneficial effects. Important: Follow the instructions on the label. Do not use more of this product, or more often, than prescribed. This medication should be swallowed whole. It should not be split, crushed or chewed. If you forget a dose, take it as soon as you remember -- unless it is almost time for your next dose. In that case, skip the missed dose. Do not double the next dose to catch up. This medication may be taken with or without food.