Toloxin

The dose varies widely depending on age, disease, weight, and kidney function. Higher doses are often given at the start of treatment to make sure there is enough medication in your body to achieve the desired effect. After this "loading dose", daily adult doses usually range between 0.0625 mg and 0.25 mg. Children's doses are individually determined by their doctor.

Toloxin (Digoxin) is normally taken once daily at the same time each day. Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important to take Toloxin (Digoxin) exactly as prescribed by your doctor. If you miss a dose, and you remember it within 12 hours, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss 2 doses in a row, call your doctor for instruction.

Store Toloxin (Digoxin) at room temperature, protect it from light, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

In addition to its desired action, this medication may cause some adverse effects, notably: it may decrease your appetite; it may cause dizziness - use caution when getting up from a lying or sitting position and use caution if driving; it may cause nausea and vomiting. Each person may react differently to a treatment. If you think this medication may be causing adverse effects (including those described here, or others), talk to your health care professional. He or she can help you to determine whether or not the medication is the source of the problem.

Tablet

0.0625 mg
Each round, peach, flat-faced, bevelled-edged tablet, debossed "TOLOXIN" over a score line and "06" under it on one side and plain on the other side, contains Toloxin (Digoxin) 0.0625 mg (62.5 µg). Nonmedicinal ingredients: FD&C Yellow No. 6, lactose, magnesium stearate, and starch (corn).

0.125 mg
Each round, yellow, flat-faced, bevelled edge tablet, debossed "TOLOXIN" over a score line and "12" under it on one side and plain on the other side, contains Toloxin (Digoxin) 0.125 mg (125 µg). Nonmedicinal ingredients: D&C Yellow No. 10, lactose, magnesium stearate, starch (corn), and yellow ferric oxide.

0.25 mg
Each round, white, biconvex tablet, debossed "TOLOXIN" over a score line and "25" under it on one side and plain on the other side, contains Toloxin (Digoxin) 0.25 mg (250 µg). Nonmedicinal ingredients: lactose, magnesium stearate, and starch (corn).

Oral solution

0.05 mg/mL

Each mL of clear, light-green coloured liquid with a lime odour and taste contains Toloxin (Digoxin) 0.05 mg (50 µg). Nonmedicinal ingredients: alcohol, calcium diatomaceous earth, citric acid, D&C Green No. 5, D&C Yellow No. 10, lime flavour, methylparaben, propylene glycol, sodium phosphate, sucrose, and water. Alcohol: 11.5 mL/100 mL. Tartrazine-free.

Do not take Toloxin (Digoxin) if you:

• are allergic to Toloxin (Digoxin) or any ingredients of the medication
• have certain abnormal heart rhythms (ventricular fibrillation)

There may be an interaction between Toloxin (Digoxin) and any of the following:

• Abiraterone acetate
• Acarbose
• aminoglycoside antibiotics (e.g., Amikacin, gentamicin, tobramycin)
• Amiodarone
• amphetamines
• antacids
• anthracycline cancer medications (e.g., Daunorubicin, Doxorubicin)
• antimalarials (e.g., chloroquine, hydroxychloroquine, Primaquine)
• antithyroid medications (e.g., Methimazole, Propylthiouracil)
• Atorvastatin
• “azole” antifungals (e.g., itraconazole, ketoconazole, Voriconazole)
• beta-adrenergic blockers (e.g., Acebutolol, Atenolol, Carvedilol, Propranolol, Sotalol, Timolol)
• boceprevir
• brimonidine
• calcium channel blockers (e.g., Diltiazem, Nifedipine, Verapamil)
• calcium supplements (e.g., calcium carbonate, calcium citrate)
• certain anticancer medications (e.g., Bleomycin, carmustine)
• Carbamazepine
• carvedilol
• Ceritinib
• Colestipol
• Cholestyramine
• Clonidine
• Cobicistat
• Colchicine
• conivaptan
• Crizotinib
• Cyclosporine
• Dexamethasone
• Dipyridamole
• diuretics (water pills; e.g., furosemide, hydrochlorothiazide, triamterene)
• Donepezil
• Dronedarone
• Eplerenone
• etravirine
• Fingolimod
• Flecainide
• Galantamine
• glycopyrrolate
• grapefruit juice
• Guanfacine
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• kaolin - pectin
• Lacosamide

• Lapatinib
• Lenalidomide
• Levothyroxine
• licorice
• Lomitapide
• macrolide antibiotics (e.g., clarithromycin, erythromycin)
• Mesalamine
• methyldopa
• methyldopa
• Midodrine
• mifepristone
• Mirabegron
• multivitamins
• nefazodone
• neomycin
• nicardipine
• Nilotinib
• non-steroidal anti-inflammatory medications (NSAIDs; e.g., Diclofenac, Ibuprofen, Naproxen)
• Octreotide
• Pasireotide
• penicillamine
• Phenytoin
• Polyethylene Glycol 3350
• Prazosin
• primidone
• Progesterone
• Propafenone
• quinidine
• quinine
• Regorafenib
• reserpine
• rifampin
• Rivastigmine
• St. John's wort
• simeprevir
• Sitagliptin
• sodium polystyrene
• Spironolactone
• Sucralfate
• sufentanil
• Sulfasalazine
• Sunitinib
• Tacrolimus
• Tamoxifen
• telaprevir
• Telmisartan
• Ticagrelor
• Tizanidine
• Tolvaptan
• Trazodone
• Trimethoprim
• vitamin D analogues (e.g., alfacalcidol, Calcitriol, cholecalciferol)

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Toloxin (Digoxin). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Toloxin (Digoxin).

Kidney function: Kidney Disease or reduced kidney function may cause Toloxin (Digoxin) to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how Toloxin (Digoxin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Toloxin (Digoxin), and whether any special monitoring is needed.

Magnesium levels: Low blood levels of magnesium increase the risk of side effects with Toloxin (Digoxin). It is important that magnesium levels be checked periodically when taking Toloxin (Digoxin).

Potassium levels: Low blood levels of potassium increase the risk of overdose with Toloxin (Digoxin). It is important that potassium levels be checked periodically, especially if you are taking medications that can change the levels of potassium in the blood (e.g., Hydrochlorothiazide, Furosemide).

Potential overdose: The difference between an effective dose and an overdose is less for this medication than for most. Therefore, it is important to take Toloxin (Digoxin) exactly as prescribed. If you develop loss of appetite, nausea, or vomiting while taking Toloxin (Digoxin), contact your doctor, as these may be signs that the dose is too high.

Thyroid function: The effect of Toloxin (Digoxin) on heart rhythm is affected by thyroid function. If you have thyroid disease, discuss with your doctor how Toloxin (Digoxin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Toloxin (Digoxin), and whether any special monitoring is needed.

Pregnancy: Toloxin (Digoxin) should be taken by pregnant women only if clearly needed. The effects on the developing baby of the mother taking Toloxin (Digoxin) during pregnancy are currently unknown.

Breast-feeding: This medication passes into breast milk. It is generally believed that the amount of Toloxin (Digoxin) in breast milk that a breast-fed infant would receive is not likely to affect the infant. Talk to your doctor about whether you should continue breast-feeding.

Children: Toloxin (Digoxin) can be prescribed to children, however the dose needed by the child changes as the child gets older. Your child’s doctor will want to closely monitor the effectiveness of Toloxin (Digoxin) for your child. Keep Toloxin (Digoxin) out of the reach of children.

Seniors: As you age, your kidney function can decrease. If this happens you may need a lower dose of Toloxin (Digoxin).

This medication is typically used only once a day. However, your pharmacist may have suggested a different schedule that is more appropriate for you. Important: Follow the instructions on the label. Do not use more of this product, or more often, than prescribed. It must be used regularly and continuously to maintain its beneficial effects. Be sure to keep an adequate supply on hand. It is not advisable to stop using this product suddenly, particularly if you have been on it for several weeks. If you are considering stopping the medication, talk to your pharmacist first. If you forget a dose, take it as soon as you remember -- unless it is almost time for your next dose. In that case, skip the missed dose. Do not double the next dose to catch up. This medication may be taken with or without food.