Dom Tiaprofenic

The recommended adult dose is 600 mg daily in 2 or 3 divided doses. It may be taken as 300 mg taken twice a day or 200 mg taken 3 times a day.

To reduce the possibility of Dom Tiaprofenic (Tiaprofenic-acid) causing upset stomach, take Dom Tiaprofenic (Tiaprofenic-acid) after meals or with milk.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Dom Tiaprofenic (Tiaprofenic-acid) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Ask your doctor or pharmacist for details.

Tiaprofenic acid should not be taken by anyone who:

• is allergic to tiaprofenic acid or to any of the ingredients of the medication
• is in the third trimester (last 3 months) of pregnancy
• is taking other medications from the same group (i.e., NSAIDs)
• has Asthma (whether it is related to anti-inflammatory medications or not)
• has had an allergic reaction to Asa or other anti-inflammatory medications (e.g., asthma, itchy and runny nose, Hives, or other allergic reactions)
• has nasal polyps
• has or has recently had an active inflammatory disease of the stomach and intestines such as stomach or intestinal ulcer or Ulcerative Colitis
• has reduced liver function or active liver disease
• has severely impaired or worsening kidney function

There may be an interaction between tiaprofenic acid and any of the following:

• aminoglycoside antibiotics (e.g., Amikacin, gentamicin, tobramycin)
• angiotensin II receptor blockers (e.g., Candesartan, Losartan, valsartin)
• angiotensin-converting enzyme inhibitors (ACE inhibitors; e.g., Enalapril, Lisinopril,Ramipril)
• ASA
• bisphosphonates (e.g., Alendronate, etidronate)
• certain blood pressure medications, including beta-blockers (e.g., Propranolol, Metoprolol, or Atenolol)
• Cholestyramine
• Clopidogrel
• Colestipol
• Cyclosporine
• Dasatinib
• Digoxin
• diuretics (e.g., Hydrochlorothiazide, Furosemide, Spironolactone)
• glucocorticoids (e.g., Hydrocortisone, Prednisone, Methylprednisolone)

• glucosamine
• Heparin
• Hydralazine
• hypoglycemics (medications used to lower your blood sugar, such as Glyburide)
• Ketorolac
• lithium
• many herbal products
• Methotrexate
• omega-3-fatty acids
• other NSAIDs (e.g., Ibuprofen or Naproxen)
• Phenytoin
• probenecid
• quinolone antibiotics (e.g., ciprofloxacin, levofloxacin, Norfloxacin)
• SSRI antidepressants (e.g., Citalopram, Escitalopram, Fluoxetine, Sertraline)
• Ticlopidine
• tricyclic antidepressants (e.g., Amitriptyline, Desipramine, Imipramine)
• vancomycin
• Warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Dom Tiaprofenic (Tiaprofenic-acid). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Dom Tiaprofenic (Tiaprofenic-acid).

HEALTH CANADA ADVISORY

June 8, 2021

Health Canada has issued new information concerning the use of non-steroidal anti-inflammatory drugs (NSAIDs). To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.

A previous advisory on non-steroidal anti-inflammatory drugs (NSAIDs) was issued on October 30, 2020.

Cardiovascular disease: As with other nonsteroidal anti-inflammatory drugs (NSAIDs), tiaprofenic acid may cause blood pressure to increase, Stroke, or Heart Attack. People with any heart or circulatory disease should discuss with their doctor how Dom Tiaprofenic (Tiaprofenic-acid) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Dom Tiaprofenic (Tiaprofenic-acid), and whether any special monitoring is needed.

Drowsiness/reduced alertness: Headache, dizziness, and lightheadedness have been reported by some people taking Dom Tiaprofenic (Tiaprofenic-acid). Do not drive vehicles or undertake other potentially hazardous activities until you have determined that Dom Tiaprofenic (Tiaprofenic-acid) does not affect you in this way.

Fluid retention: As with many other NSAIDs, fluid retention has been reported. Tiaprofenic acid should be used with caution by anyone who:

• is recovering from surgical operations under general anesthesia
• has any other condition that might lead to fluid retention
• has certain heart conditions
• has high blood pressure
• has Kidney Disease

People with any of the above conditions should discuss with their doctor how Dom Tiaprofenic (Tiaprofenic-acid) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Dom Tiaprofenic (Tiaprofenic-acid), and whether any special monitoring is needed.

Kidney function: Tiaprofenic acid has occasionally been known to cause kidney damage. People with reduced kidney function or kidney disease should discuss with their doctor how Dom Tiaprofenic (Tiaprofenic-acid) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Dom Tiaprofenic (Tiaprofenic-acid), and whether any special monitoring is needed. If you are taking the medication for a long period of time, your doctor may recommend kidney function tests.

Liver function: Other medications from the same group as tiaprofenic acid (NSAIDs) have occasionally caused liver damage. People with reduced liver function or liver disease should discuss with their doctor how Dom Tiaprofenic (Tiaprofenic-acid) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Dom Tiaprofenic (Tiaprofenic-acid), and whether any special monitoring is needed.

Stop taking the medication and contact your doctor as soon as possible if you notice signs of liver damage, such as yellow eyes or skin, abdominal pain, itchy skin, pale stools, or dark urine. Your doctor may recommend regular liver function tests if you are taking Dom Tiaprofenic (Tiaprofenic-acid) for a long period of time.

Ulcers: Tiaprofenic acid may increase the risk of ulcers in the stomach and intestines. It should be taken under close medical supervision by people prone to irritation of the stomach and intestines, particularly those people who have had a stomach ulcer, blood in the stools, or diverticulosis or another inflammatory disease of the stomach or intestines (such as ulcerative colitis or Crohn's Disease). In these cases, the doctor must weigh the benefits of treatment against the possible risks. Stop taking the medication and seek immediate medical attention if you develop symptoms of a bleeding ulcer such as dark tarry stools, blood in the stools, or the vomiting up of blood or material that looks like coffee grounds.

Pregnancy: Tiaprofenic acid should not be used during early pregnancy unless the benefits outweigh the risks. If it is taken close to the end of pregnancy, it may prolong labour. If you become pregnant while taking Dom Tiaprofenic (Tiaprofenic-acid), contact your doctor immediately.

Breast-feeding: Tiaprofenic acid passes into breast milk. If you are a breast-feeding mother and are taking tiaprofenic acid, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of Dom Tiaprofenic (Tiaprofenic-acid) have not been established for children.

Seniors: Seniors who take Dom Tiaprofenic (Tiaprofenic-acid) should be closely monitored by their doctors. Seniors may be more likely to develop side effects to tiaprofenic acid and may require a lower dose.