Dysport Aesthetic

The dose of medication required depends on the area being treated and individual circumstances.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are receiving the medication without consulting your doctor.

Botulinum toxin is available in injectable form. The injection will be given into a muscle by a qualified health care professional.

It is important to receive Dysport Aesthetic (Abobotulinumtoxin-a) exactly as recommended by your doctor. If you miss an appointment to receive botulinum toxin type A (cosmetic), contact your doctor as soon as possible to reschedule your appointment. It is very important to keep your appointments for treatment and follow-up.

Before mixing, Dysport Aesthetic (Abobotulinumtoxin-a) is stored in the refrigerator and protected from light. Once mixed, it can be stored for up to 24 hours in the refrigerator.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

300 units
Each sterile vial contains 300 units of lyophilized abobotulinumtoxinA. Nonmedicinal ingredients: human serum Albumin and lactose.

Dysport Therapeutic

300 units
Each sterile vial contains 300 units of lyophilized abobotulinumtoxinA. Nonmedicinal ingredients: human serum albumin and lactose.

500 units
Each sterile vial contains 500 units of lyophilized abobotulinumtoxinA. Nonmedicinal ingredients: human serum albumin and lactose.

Do not use botulinum toxin type A (Dysport) if you:

• are allergic to botulinum toxin or to any of the ingredients of the medication
• are allergic to cow's milk protein
• have an infection at the site the injection is to be given in
• have Myasthenia Gravis, amyotrophic lateral sclerosis, or Eaton Lambert syndrome

There may be an interaction between botulinum toxin type A (Dysport) and any of the following:

• aclidinium
• aminoglycoside antibiotics (e.g., gentamicin, neomycin, tobramycin, streptomycin)
• antihistamines (e.g., brompheniramine, Diphenhydramine)
• antipsychotics (e.g. Clozapine, Olanzapine, Risperidone)
• atropine
• azelastine
• belladonna
• Benztropine
• clidinium
• Darifenacin
• Flavoxate
• glycopyrrolate
• ipratropium
• Moclobemide
• muscle relaxants (e.g. Cyclobenzaprine, orphenadrine)
• Oxybutynin
• polymyxins (e.g., polymyxin B)
• quinidine
• scopolamine
• Solifenacin
• tiotropium
• Tolterodine
• tricyclic antidepressants (e.g., Amitriptyline, Clomipramine, Imipramine)
• Trospium
• umeclidinium

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Dysport Aesthetic (Abobotulinumtoxin-a). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Dysport Aesthetic (Abobotulinumtoxin-a).

Distant toxin spread: Very rarely, Dysport Aesthetic (Abobotulinumtoxin-a) may spread to other parts of the body other than where it was injected, leading to muscle weakness, difficulty swallowing, pneumonia, speech difficulties, and breathing problems. Distant toxin spread can be fatal. If you develop severe difficulty swallowing, speaking, or breathing while using Dysport Aesthetic (Abobotulinumtoxin-a), contact your doctor immediately. Dysport Aesthetic (Abobotulinumtoxin-a) should be used with caution in people who have pre-existing swallowing, breathing, or nerve problems.

Heart problems: There have been rare reports of heart problems such as irregular heart rhythms and Heart Attack following injection of Dysport Aesthetic (Abobotulinumtoxin-a). If you have heart disease discuss with your doctor how Dysport Aesthetic (Abobotulinumtoxin-a) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Dysport Aesthetic (Abobotulinumtoxin-a), and whether any special monitoring is needed.

Other medical conditions: People with amyotrophic lateral sclerosis, with disorders that produce a depletion of acetylcholine, or disorders that produce peripheral neuromuscular dysfunction should discuss with their doctor how Dysport Aesthetic (Abobotulinumtoxin-a) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Dysport Aesthetic (Abobotulinumtoxin-a), and whether any special monitoring is needed.

Pregnancy: Dysport Aesthetic (Abobotulinumtoxin-a) should be used during pregnancy only if the potential benefit justifies the potential risk to the mother and unborn baby. If you become pregnant while using Dysport Aesthetic (Abobotulinumtoxin-a), contact your doctor immediately.

Breast-feeding: It is not known if Dysport Aesthetic (Abobotulinumtoxin-a) passes into breast milk. If you are a breast-feeding mother and are using Dysport Aesthetic (Abobotulinumtoxin-a), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of Dysport Aesthetic (Abobotulinumtoxin-a) have not been established for children under the age of 18, except for the treatment of lower limb spasticity in children over the age of 2 years.