Lixiana

To prevent a first stroke in people with atrial fibrillation, the recommended dose is 60 mg taken by mouth, once daily.

To treat and prevent recurring DVT and PE, the recommended dose is 60 mg taken by mouth, once daily. This is to be started after 5 to 10 days of Heparin given intravenously (through a vein).

Lixiana (Edoxaban) may be taken with food or on an empty stomach.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Lixiana (Edoxaban) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Lixiana (Edoxaban) at room temperature, protect it from moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

In addition to its desired action, this medication may cause some adverse effects, notably: it may cause anemia (low red blood cells); it may cause spots or redness of the skin; it may reduce your blood clotting ability. Each person may react differently to a treatment. If you think this medication may be causing adverse effects (including those described here, or others), talk to your health care professional. He or she can help you to determine whether or not the medication is the source of the problem.

15 mg
Each orange, round, film-coated tablet debossed with "DSC L15" contains 20.2 mg of Lixiana (Edoxaban) tosylate monohydrate equivalent to 15 mg of Lixiana (Edoxaban). Nonmedicinal ingredients: carnauba wax, crospovidone, hydroxypropyl cellulose, magnesium stearate, mannitol, pregelatinized starch, talc, iron oxide yellow, iron oxide red, polyethylene glycol 8000, talc, and titanium dioxide.

30 mg
Each pink, round, film-coated tablet debossed with "DSC L30" contains 40.41 mg of Lixiana (Edoxaban) tosylate monohydrate equivalent to 30 mg of Lixiana (Edoxaban). Nonmedicinal ingredients: carnauba wax, crospovidone, hydroxypropyl cellulose, magnesium stearate, mannitol, pregelatinized starch, talc. Nonmedicinal ingredients: carnauba wax, crospovidone, hydroxypropyl cellulose, magnesium stearate, mannitol, pregelatinized starch, talc, iron oxide red, polyethylene glycol 8000, talc, and titanium dioxide.

60 mg
Each yellow, round, film-coated tablet debossed with "DSC L60" contains 80.82 mg of Lixiana (Edoxaban) tosylate monohydrate equivalent to 60 mg of Lixiana (Edoxaban). Nonmedicinal ingredients: carnauba wax, crospovidone, hydroxypropyl cellulose, magnesium stearate, mannitol, pregelatinized starch, talc, iron oxide yellow, polyethylene glycol 8000, talc, and titanium dioxide.

Do not take Lixiana (Edoxaban) if you:

• are allergic to Lixiana (Edoxaban) or any ingredients of the medication
• are currently experiencing severe or dangerous bleeding
• are taking any other medication to reduce the risk of clotting (i.e., blood "thinners"), such as:
  • Apixaban
  • dabigatran
  • heparin
  • low-molecular-weight heparin (e.g., Tinzaparin, Enoxaparin)
  • Warfarin
• have a condition that increases the risk of experiencing severe or dangerous bleeding, such as a stomach ulcer or recent stroke
• have liver disease that also affects your clotting ability
• are or may become pregnant
• are breast-feeding

There may be an interaction between Lixiana (Edoxaban) and any of the following:

• acetylsalicylic acid (Asa)
• Amiodarone
• apixaban
• "azole" antifungals (e.g., itraconazole, ketoconazole, Voriconazole)
• Carbamazepine
• Carvedilol
• Celecoxib
• Clopidogrel
• Cobicistat
• Cyclosporine
• dabigatran
• Deferasirox
• Dexamethasone
• Dipyridamole
• Dronedarone
• Elagolix
• estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
• Flibanserin
• heparin
• Hepatitis C antivirals (e.g., daclatasvir, ledipasvir, ombitasvir, velpatasvir)
• herbal products that affect blood clotting (e.g., cat's claw, chamomile, fenugreek, evening primrose, feverfew, garlic, ginger, ginseng, turmeric)
• Ivacaftor
• Lomitapide
• low-molecular-weight heparins (e.g., Dalteparin, enoxaparin, tinzaparin)
• macrolide antibiotics (e.g., azithromycin, clarithromycin, erythromycin)
• Mefloquine
• mifepristone
• non-steroidal anti-inflammatory medications (NSAIDs; e.g., Diclofenac, Ibuprofen, Naproxen)
• Obinutuzumab
• omega-3 fatty acids
• Phenytoin
• Prasugrel
• Prazosin
• progestins (e.g., Dienogest, Levonorgestrel, medroxyprogesterone, Norethindrone)
• Propafenone
• Propranolol
• protein kinase inhibitors (e.g., Dasatinib, Crizotinib, Nilotinib, Sunitinib)
• quinidine
• quinine
• rifampin
• ritonavir
• Rivaroxaban
• St. John's wort
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• serotonin-norepinephrine reuptake inhibitors (SNRIs; Desvenlafaxine, Duloxetine, Venlafaxine)
• Ticagrelor
• Ticlopidine
• tipranavir
• Verapamil
• vitamin E
• warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Lixiana (Edoxaban). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Lixiana (Edoxaban).

Bleeding: Lixiana (Edoxaban) is intended to decrease dangerous clotting, but it can contribute to serious and possibly deadly bleeding. If you experience an increase in bruising, difficulty stopping bleeding from cuts, or increased nosebleeds, contact your doctor as soon as possible. If you experience symptoms of bleeding from the stomach, such as vomiting material that looks like coffee grounds, passing blood in the stool, or coughing up blood, seek immediate medical attention.

Kidney function: Decreased kidney function or Kidney Disease can cause Lixiana (Edoxaban) to build up in the body, increasing the risk of side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how Lixiana (Edoxaban) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Lixiana (Edoxaban), and whether any special monitoring is needed.

Liver function: The safety and effectiveness of using Lixiana (Edoxaban) if you have severely reduced liver function has not been determined. If you have reduced liver function or liver disease, discuss with your doctor how Lixiana (Edoxaban) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Lixiana (Edoxaban), and whether any special monitoring is needed. Lixiana (Edoxaban) is not recommended for people with severe liver dysfunction.

Spinal or epidural catheters: Lixiana (Edoxaban) should not be taken by people who have spinal or epidural catheters in place (or for 5 hours after their removal) or by people receiving pain medications through an epidural catheter.

Stopping the medication: If you need to discontinue Lixiana (Edoxaban), talk to your doctor. If the Lixiana (Edoxaban) is stopped too early, there is an increased risk of experiencing a dangerous blood clot.

Surgery: If you are going to have surgery or a dental procedure, let your doctors know that you are taking Lixiana (Edoxaban). Depending on the type of surgery, your doctor may stop Lixiana (Edoxaban) to reduce the risk of increased bleeding during surgery and delayed healing afterward.

Pregnancy: Lixiana (Edoxaban) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Lixiana (Edoxaban), contact your doctor immediately.

Breast-feeding: It is not known if Lixiana (Edoxaban) passes into breast milk. If you are a breast-feeding mother and are taking Lixiana (Edoxaban), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Lixiana (Edoxaban) have not been established for children.

This medication is typically used only once a day. However, your pharmacist may have suggested a different schedule that is more appropriate for you. Important: Follow the instructions on the label. Do not use more of this product, or more often, than prescribed. You should take this medication at approximately the same time each day. If you forget a dose, take it as soon as you remember, but do not take two doses the same day. This medication may be taken with or without food.