Duotrav Pq

The recommended adult dose of travoprost - timolol is one drop in the affected eye(s) once daily. Do not use it more than once a day.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

To use the eye drops:

1. Wash your hands before using the eye drops.
2. Remove the cap and place it in a clean location. To avoid possible contamination keep the tip of the container away from contact with any surface.
3. Tilt your head back and look towards the ceiling.
4. With your index finger, gently pull the lower eyelid down and away from the eye to form a pouch.
5. Apply one drop into the pouch but do not allow the tip of the container to touch the eye or areas around the eye.
6. Gently apply pressure to the inner corner of the eye (at the bridge of the nose) for about 30 seconds (this is called nasolacrimal occlusion). This prevents the medication from dripping down through the tear duct and entering the bloodstream, which could cause you to experience some side effects.
7. Repeat with the other eye, if prescribed by your physician.
8. Wash your hands again to remove any medication.

Do not allow the dropper tip of the bottle to touch the eye or other surrounding structures. This can contaminate the tip with common bacteria known to cause Eye Infections. Serious damage to the eye, possibly leading to loss of vision may result if you use eye drop solutions that have become contaminated.

If you use other eye drops as well, wait at least 5 minutes before using them.

If you wear contact lenses, remove them before instilling travoprost - timolol into your eye. You may put your contact lenses back in 15 minutes after using the medication.

It is important to use Duotrav Pq exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not administer a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Duotrav Pq at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

0.004%/ 0.5% eye drops
Each mL of sterile, isotonic, buffered, preserved, aqueous solution contains travoprost 0.04 mg and timolol 5.0 mg. Nonmedicinal ingredients:POLYQUAD (polyquaternium-1), mannitol, polyoxyethylene hydrogenated castor oil 40, propylene glycol, boric acid, sodium chloride, sodium hydroxide and or hydrochloric acid and purified water.

Do not use Duotrav Pq if you:

• are allergic to travoprost, timolol, or any ingredients of the medication
• have Asthma or have had asthma in the past
• have certain heart diseases or conditions:
  • cardiogenic shock (heart cannot provide enough oxygen to the body)
  • second-degree or third-degree atrioventricular (AV) block or sick sinus syndrome (electrical problems)
  • sinus bradycardia (slow heartbeat)
  • uncontrolled heart failure (heart cannot pump effectively)
• have severe COPD (Chronic Obstructive Pulmonary Disease) (COPD)

There may be an interaction between travoprost - timolol eye drops and any of the following:

• Abiraterone acetate
• acetylcholine
• alpha/beta agonists (e.g., Epinephrine, norepinephrine)
• alpha agonists (e.g., Clonidine, methyldopa)
• alpha-1 blockers (e.g., Doxazosin, Tamsulosin, Terazosin)
• Amiodarone
• anaesthetics
• anti-malarial medications (e.g., chloroquine, hydroxychloroquine, Primaquine)
• antipsychotics (e.g., Chlorpromazine, Haloperidol, trifluoperazine)
• Aripiprazole
• barbiturates (e.g., butalbital, Phenobarbital)
• benzodiazepines (e.g., Diazepam, Lorazepam)
• beta-adrenergic blockers (e.g., Atenolol, Metoprolol, Propranolol)
• beta-2 agonists (e.g., salbutamol, formoterol, terbutaline)
• brimonidine
• Bromocriptine
• bupivacaine
• Bupropion
• Cabergoline
• calcium channel blockers (e.g., Nifedipine, Verapamil)
• carbachol
• Celecoxib
• Cimetidine
• Cinacalcet
• Clobazam
• clonidine
• Clozapine
• Cobicistat
• Darifenacin
• darunavir
• delavirdine
• Digoxin
• Diphenhydramine
• Dipyridamole
• Disopyramide
• Donepezil
• Dronedarone
• ergot alkaloids (e.g., Dihydroergotamine, ergonovine, ergotamine, methylergonovine)
• Fingolimod
• Galantamine
• grass pollen allergen extract
• Guanfacine
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• isoniazid
• ketoconazole
• Lanreotide
• lidocaine
• Methadone
• methyldopa
• Midodrine
• Mirabegron
• monoamine oxidase inhibitors (M.O.S. e.g., Phenelzine, Tranylcypromine)
• Octreotide
• opiate medications (e.g., Codeine, Hydrocodone, Morphine)
• Pasireotide
• peginterferon alfa-2b
• Pilocarpine
• Propafenone
• certain protein kinase inhibitors (e.g., Ceritinib, imatinib, Nilotinib, Tofacitinib)
• pyridostigmine
• quinidine
• quinine
• rifabutin
• rifampin
• Rituximab
• Rivastigmine
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• sulfonylurea diabetes medications (e.g., Gliclazide, Glyburide, Tolbutamide)
• terbinafine
• Ticlopidine
• Tizanidine
• theophyllines (e.g., Aminophylline, Oxtriphylline, Theophylline)
• tranylcypromine
• tricyclic antidepressants (e.g., Amitriptyline, Clomipramine, Desipramine, Trimipramine)

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Duotrav Pq. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Duotrav Pq.

Allergy: People who have a history of allergies or anaphylactic reactions are more likely to experience these reactions while using travoprost - timolol eye drops. If you have a history of severe allergic reactions, you should discuss with your doctor how Duotrav Pq may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Duotrav Pq, and whether any special monitoring is needed.

Asthma and respiratory disease: Although Duotrav Pq is intended to be used as a topical (surface only) treatment for the eyes, it may be absorbed into the bloodstream and affect breathing if you have a history of breathing problems or difficulty breathing. If you have asthma or other respiratory conditions, discuss with your doctor how Duotrav Pq may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Duotrav Pq, and whether any special monitoring is needed.

Contact lenses: If you wear contact lenses, remove the lenses before using the eye drops and wait at least 15 minutes before reinserting them.

Diabetes: Although Duotrav Pq is intended to be used as a topical treatment for the eyes, it may be absorbed into the bloodstream and affect blood sugar control if you have diabetes. If you have diabetes, discuss with your doctor how Duotrav Pq may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Duotrav Pq, and whether any special monitoring is needed. You may need to test your blood sugar more often while you are using Duotrav Pq.

Drowsiness/reduced alertness: Duotrav Pq may cause drowsiness, dizziness, and temporary blurring of your vision. Do not drive, operate machinery, or engage in any potentially hazardous activities until you determine how Duotrav Pq affects you.

Eye changes: Duotrav Pq may gradually change the colour of the eye, increasing the amount of brown pigment in the iris (coloured part of the eye). The long-term effects on the eye and the chances of injury to the eye are currently unknown. As the change in colour may be permanent and occurs slowly, it may not be noticeable for several months or years. Duotrav Pq can also cause darkening, thickening, and lengthening of eyelashes. Eyelid skin darkening may also occur. Talk to your doctor if you have any concerns.

Eye conditions: If you have certain types of eye conditions (e.g., glaucoma, uveitis, certain lens problems), discuss with your doctor how Duotrav Pq may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Duotrav Pq, and whether any special monitoring is needed. If you experience frequent or chronic eye inflammation, discuss the risks and benefits of using Duotrav Pq with your doctor.

Kidney problems: If you have decreased kidney function or Kidney Disease, discuss with your doctor how Duotrav Pq may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Duotrav Pq, and whether any special monitoring is needed.

Liver problems: If you have reduced liver function or liver disease, discuss with your doctor how Duotrav Pq may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Duotrav Pq, and whether any special monitoring is needed.

Myasthenia Gravis: The timolol component of Duotrav Pq may cause increased muscle weakness for people with myasthenia gravis. If you have myasthenia gravis, discuss with your doctor how Duotrav Pq may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Duotrav Pq, and whether any special monitoring is needed.

Severe cardiovascular (heart) disease: Although Duotrav Pq is intended to be used as a topical treatment for the eyes, it may be absorbed into the bloodstream and have an effect on heart disease. If you have heart disease, discuss with your doctor how Duotrav Pq may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Duotrav Pq, and whether any special monitoring is needed.

Thyroid disease: If you have thyroid disease (e.g., Hyperthyroidism), discuss with your doctor how Duotrav Pq may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Duotrav Pq, and whether any special monitoring is needed.

Pregnancy: The medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Duotrav Pq, contact your doctor immediately.

Breast-feeding: Timolol passes into breast milk after being used as an eye drop. It is not known if travoprost passes into breast milk. If you are a breast-feeding mother and are using travoprost - timolol eye drops, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Duotrav Pq have not been established for children.