Endometrin

Vaginal gel: The recommended dose of progesterone vaginal gel is 90 mg (one applicator) inserted into the vagina once or twice daily, starting the day of embryo transfer. If pregnancy occurs, treatment may be continued for up to 12 weeks.

To insert progesterone vaginal gel, hold the applicator by the thick end and shake down to ensure the contents are at the thin end. Twist off the tab and gently insert the thin end of the applicator into the vagina while you are in a sitting position or when lying on your back with your knees bent. Press the thick end of the applicator firmly to deposit the gel. Remove and discard the applicator. Applicators are intended for a single use only.

Vaginal tablets: The recommended dose of progesterone vaginal tablets is 100 mg inserted into the vagina 2 or 3 times daily starting the day after egg retrieval. If pregnancy occurs, treatment may be continued for up to 10 weeks.

To insert progesterone vaginal tablets, place one tablet in the space provided at the end of the applicator. The tablet should fit snugly and not fall out. While sitting, standing, or lying on your back with your knees bent, gently insert the thin end of the applicator (the one containing the tablet) well into the vagina. Push the plunger to release the tablet. Remove and discard the applicator. Applicators are intended for a single use only.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important to use Endometrin (Progesterone-vaginal) exactly as prescribed by your doctor. If you miss a dose, use it the following day and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Endometrin (Progesterone-vaginal) at room temperature, protect it from extreme heat or cold, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

In addition to its desired action, this medication may cause some adverse effects, notably: it may cause headaches; it may cause constipation - to prevent this, drink plenty of water or juice, and eat more dietary fibre; it may cause nausea or, rarely, vomiting; it may cause your breasts to feel swollen and tender; it may cause drowsiness - use caution when driving; it may increase breast size. Each person may react differently to a treatment. If you think this medication may be causing adverse effects (including those described here, or others), talk to your health care professional. He or she can help you to determine whether or not the medication is the source of the problem.

Each white to off-white oblong-shaped effervescent vaginal tablet, debossed with "FPI" on one side and "100" on the other side, contains progesterone 100 mg. Nonmedicinal ingredients: lactose monohydrate, polyvinylpyrrolidone, adipic acid, sodium bicarbonate, sodium lauryl sulfate, magnesium stearate, pregelatinized starch, and colloidial silicone dioxide.

Do not use Endometrin (Progesterone-vaginal) if you:

• are allergic to progesterone or any ingredients of Endometrin (Progesterone-vaginal)
• had a miscarriage and the doctor suspects some tissue is still in the uterus
• have abnormal vaginal bleeding that has not been checked by a doctor
• have an Ectopic Pregnancy (a pregnancy that occurs outside of the womb)
• have decreased liver function or liver disease
• have diagnosed or suspected breast or genital cancer (e.g., vaginal, uterine, ovarian)
• have diagnosed or suspected cancer that depends on progesterone to grow
• have or have had inflammation of the veins or a history of Blood Clots problems
• have porphyria

There may be an interaction between progesterone vaginal gel or vaginal tablets and any of the following:

• Aliskiren
• Amiodarone
• Apixaban
• bexarotene
• Bosentan
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
• certain cancer medications (e.g., Daunorubicin, Doxorubicin, Etoposide, Irinotecan, Vinblastine)
• Carbamazepine
• Carvedilol
• cetirizine
• ciprofloxacin (systemic)
• Colchicine
• Cyclosporine
• dabigatran
• Deferasirox
• Dexamethasone
• diabetes medications (e.g., chlorpropamide, glipizide, Glyburide, insulin, Metformin, Nateglinide, Rosiglitazone)
• Digoxin
• dofetilide
• Everolimus
• estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
• Heparin
• HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., efavirenz, etravirine, nevirapine)
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• Hydrocortisone
• ketoconazole
• certain kinase inhibitors (e.g., Bosutinib, Dabrafenib, imatinib, Pazopanib)

• Lomitapide
• Loperamide
• low molecular weight heparins (e.g., Dalteparin, Enoxaparin, Tinzaparin)
• Modafinil
• Morphine
• Nadolol
• Ondansetron
• Paliperidone
• Phenobarbital
• Phenytoin
• Pimozide
• primidone
• Prucalopride
• quinidine
• quinine
• Ranitidine
• rifabutin
• rifampin
• Risperidone
• Rivaroxaban
• Romidepsin
• St. John's wort
• Silodosin
• Sirolimus
• "statin" anti-cholesterol medications (e.g., Atorvastatin, Lovastatin, Simvastatin)
• Tacrolimus
• telaprevir
• Tolvaptan
• Warfarin
• other vaginal medications or treatments (e.g., Clotrimazole, miconazole)

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Endometrin (Progesterone-vaginal). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Endometrin (Progesterone-vaginal).

Blood clots: Endometrin (Progesterone-vaginal) may cause blood clots. If you experience pain, swelling, or redness in your calf or leg; chest pain; shortness of breath; difficulty breathing; eye pain or vision changes; get immediate medical attention.

Depression: Hormones, such as progesterone, have been known to cause mood swings and symptoms of depression. If you have depression or a history of depression, discuss with your doctor how Endometrin (Progesterone-vaginal) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Endometrin (Progesterone-vaginal), and whether any special monitoring is needed.

If you experience symptoms of depression such as poor concentration, changes in weight, changes in sleep, decreased interest in activities, or notice them in a family member who is taking Endometrin (Progesterone-vaginal) contact your doctor as soon as possible.

Diabetes: Progesterone may cause an increase in blood sugar levels (may cause a loss of blood glucose control) and glucose tolerance may change. People with diabetes may find it necessary to monitor their blood sugar more frequently while using Endometrin (Progesterone-vaginal).

Drowsiness/reduced alertness: Progesterone may cause drowsiness. Do not drive or operate machinery until you know how Endometrin (Progesterone-vaginal) affects you.

Fluid retention: Progesterone can cause fluid retention. If you have Epilepsy, migraines, Asthma, or heart or kidney problems, discuss with your doctor how Endometrin (Progesterone-vaginal) may affect your medical condition and whether any special monitoring is needed.

Heart attack: The risk of heart attack is increased with the use of progesterone, due to the increased risk of blood clots. If you experience symptoms of heart attack, such as sudden chest pain or pressure on the chest, a sense of dread, difficulty breathing, nausea or pain radiating from the shoulder to the jaw or arm, seek immediate medical help.

Liver: Endometrin (Progesterone-vaginal) may cause liver problems. If you experience yellowing of the skin or eyes, nausea, vomiting, abdominal pain, light-coloured stools, or dark urine, contact your doctor. Your doctor will monitor your liver function while you are using this medication.

Other vaginal medications: Progesterone vaginal gel or tablets should not be used at the same time as other vaginal medications or products. Wait at least 6 hours after using progesterone vaginal gel before using other vaginal medications or products.

Stroke: Endometrin (Progesterone-vaginal) increases the risk of a stroke occurring. If you experience signs of a stroke, such as confusion, difficulty speaking, loss of coordination, sudden headache or vision changes, contact your doctor as soon as possible.

Vaginal bleeding: If you experience vaginal bleeding while using Endometrin (Progesterone-vaginal), contact your doctor.

Pregnancy: Endometrin (Progesterone-vaginal) can be used for up to 10 to 12 weeks to maintain pregnancy.

Breast-feeding: This medication may pass into breast milk. If you are a breast-feeding mother and are using vaginal progesterone, it may affect your baby. Breast-feeding is not recommended while you are using Endometrin (Progesterone-vaginal).

Children: The safety and effectiveness of using Endometrin (Progesterone-vaginal) have not been established for children. Endometrin (Progesterone-vaginal) is not intended for use by children.

Seniors: Endometrin (Progesterone-vaginal) is intended for use by women of child-bearing age. Its safety and effectiveness have not been established for seniors.

This medication is to be used vaginally. Use the product for the prescribed period of time and follow the directions for use included in the package. When applying this product, you may feel a slight irritation at first. If the irritation becomes severe or continues longer than a few minutes, consult your health care professional. Use this medication regularly and continuously to maintain its beneficial effects.