Nadolol

The recommended adult dose of nadolol ranges from 40 mg to 320 mg in one daily dose, with or without food.

For the treatment of angina pectoris or high blood pressure, the recommended starting dose is 80 mg once daily. If the desired response is not achieved after one week, your doctor may increase the daily dose by 80 mg each week (e.g., in Week 1, the dose is 80 mg; in Week 2, the dose is 160 mg; etc.), until the blood pressure or chest pain is controlled.

The maximum recommended daily dose is 240 mg for treatment of angina pectoris and 320 mg for treatment of high blood pressure.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Nadolol exactly as prescribed by your doctor. If you miss a dose skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

In addition to its desired action, this medication may cause some adverse effects, notably: it may cause diarrhea or constipation, depending on the person; it may cause dizziness - use caution when getting up from a lying or sitting position and use caution if driving; it may cause either drowsiness or excitability - use caution until you know how you will react; it may lower your sex drive (libido). Each person may react differently to a treatment. If you think this medication may be causing adverse effects (including those described here, or others), talk to your health care professional. He or she can help you to determine whether or not the medication is the source of the problem.

40 mg
Each round, white, biconvex tablet, scored and engraved "N40" below the bisect on one side, contains 40 mg of nadolol. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose monohydrate, magnesium stearate, and microcrystalline cellulose.

80 mg
Each round, white, biconvex tablet, scored and engraved "N80" on one side, contains 80 mg of nadolol. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose monohydrate, magnesium stearate, and microcrystalline cellulose.

160 mg
Each blue, capsule-shaped, biconvex tablet, scored and engraved bisect and “160” on one side, contains 160 mg of nadolol. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, FD&C Blue No. 1, FD&C Blue No. 2, lactose monohydrate, magnesium stearate, and microcrystalline cellulose.

Do not take Nadolol if you:

• are allergic to nadolol or any ingredients of the medication
• are being treated with anesthetics that reduce the function of the heart (e.g., ether)
• are in cardiogenic shock
• have a severely slow heart rate
• have Allergic Rhinitis
• have Asthma or a history of other obstructive airway disease
• have right ventricular failure caused by pulmonary hypertension (high blood pressure in the lungs)
• have serious heart block (second- and third-degree AV block) or sick sinus syndrome
• have uncontrolled Congestive Heart Failure

There may be an interaction between nadolol and any of the following:

• Abiraterone acetate
• Aldesleukin
• Aliskiren
• alpha-1 blockers (e.g., Doxazosin, Prazosin, Tamsulosin)
• alpha-2 blockers (e.g., Clonidine, dexmedetomidine, methyldopa)
• amifostine
• Amiodarone
• amphetamines (e.g., Dextroamphetamine, lisdexamphetamine, phentermine)
• angiotensin converting enzyme inhibitors (ACEIs; e.g., Captopril, Ramipril)
• angiotensin II receptor blockers (i.e., Irbesartan, losartian, Valsartan)
• anti-psychotics (e.g., Clozapine, Olanzapine, Quetiapine, Risperidone)
• Atorvastatin
• asunaprevir
• azole antifungals (e.g., itraconazole, ketoconazole, posaconazole)
• barbiturates (e.g., Phenobarbital)
• benzodiazepines (e.g., Alprazolam, Diazepam, Lorazepam)
• beta-agonists (e.g., formoterol, salbutamol, salmeterol)
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
• brimonidine
• Carbamazepine
• Ceritinib
• Cobicistat
• Crizotinib
• Cyclosporine
• daclatasvir
• Dexamethasone
• Digoxin
• Dipyridamole
• Disopyramide
• diuretics (water pills; e.g., Furosemide, Hydrochlorothiazide)
• Donepezil
• Dronedarone
• Duloxetine
• epinephrine
• ergot alkaloids (e.g., Dihydroergotamine, methysergide)
• Fentanyl
• Fingolimod
• Floctafenine
• Galantamine
• ginger
• ginseng
• grapefruit juice
• grass pollen allergen extract guanethidine
• HIV protease inhibitors (e.g., nelfinavir, ritonavir, saquinavir)
• insulin
• Lanreotide
• Lapatinib
• levodopa
• licorice
• lidocaine
• Lomitapide
• MAO inhibitors (e.g., Phenelzine, Moclobemide, Selegiline)
• macrolide antibiotics (e.g., azithromycin, clarithromycin, erythromycin)
• Mefloquine
• Methylphenidate
• Minoxidil
• nefazodone
• Nilotinib
• nitrates (e.g., Nitroglycerin, isosorbide dinitrate, isosorbide mononitrate)
• nonsteroidal anti-inflammatory drugs (NSAIDs; e.g., Ibuprofen, Naproxen)
• Obinutuzumab
• Octreotide
• other beta-blockers (e.g., Atenolol, Metoprolol, Propranolol)
• Pasireotide
• Pentoxifylline
• phosphodiesterase-5-inhibitors (e.g., Sildenafil, Tadalafil)
• Pilocarpine
• Progesterone
• Propafenone
• quinidine
• quinine
• reserpine
• rifampin
• Riociguat
• Rivastigmine
• St. John's wort
• sacubitril
• sulfonylureas (e.g., Gliclazide, Glyburide, Tolbutamide)
• Sunitinib
• Tacrolimus
• Tamoxifen
• tenofovir
• theophyllines (e.g., Aminophylline, Oxtriphylline, Theophylline)
• Ticagrelor
• tipranavir
• Tizanidine
• Vinblastine
• Yohimbine

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Nadolol. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Nadolol.

Breathing problems: Nadolol may make symptoms of asthma and certain other breathing problems worse. If you have asthma, other breathing problems, or a history of breathing problems, discuss with your doctor how Nadolol may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nadolol, and whether any special monitoring is needed.

Diabetes: The signs of low blood sugar may not be as noticeable when you are taking nadolol. If you have diabetes and take insulin or other medications that affect blood glucose levels, discuss with your doctor how Nadolol may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nadolol, and whether any special monitoring is needed. It may be necessary to monitor your blood glucose levels more often when you are taking Nadolol.

Dizziness: Occasionally, blood pressure drops too low after taking nadolol, causing dizziness or lightheadedness. This is more likely to happen when you first start to take Nadolol. To reduce the likelihood of this happening, move slowly when changing from a lying or sitting position to a standing position to reduce the severity of dizziness.

Heart failure: Taking Nadolol if you have heart problems may cause the symptoms of heart disease to worsen. If you have heart failure or a history of heart disease, discuss with your doctor how Nadolol may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nadolol, and whether any special monitoring is needed.

Hyperthyroidism (high level of Thyroid hormones): Nadolol may reduce the symptoms of hyperthyroidism, giving a false impression that the condition is improving. If you have hyperthyroidism, discuss with your doctor how Nadolol may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nadolol, and whether any special monitoring is needed.

Kidney function: Kidney Disease or reduced kidney function may cause Nadolol to build up in the body, causing side effects. If you have kidney problems, discuss with your doctor how Nadolol may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nadolol, and whether any special monitoring is needed.

Mental health: If you have a history of Depression or other psychiatric illness, discuss with your doctor how Nadolol may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nadolol, and whether any special monitoring is needed.

Myasthenia Gravis: The signs of worsening myasthenia gravis may not be as noticeable for people taking nadolol. If you have myasthenia gravis, discuss with your doctor how Nadolol may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nadolol, and whether any special monitoring is needed.

Peripheral vascular disease: Nadolol may worsen the symptoms of diseases of the blood vessels, such as Raynaud's disease. If you have a condition involving the blood vessels, discuss with your doctor how Nadolol may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nadolol, and whether any special monitoring is needed.

Psoriasis: Nadolol has been related to the development or worsening of psoriasis, although how this occurs is not known. If you have psoriasis or a history of psoriasis, discuss with your doctor how Nadolol may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nadolol, and whether any special monitoring is needed.

Severe allergies: Nadolol may make it more difficult to treat severe allergic reactions with Epinephrine. If you have allergies that are severe enough to cause Anaphylaxis (severe allergic reaction) (a severe allergic reaction where swelling of the face, lips, and throat make it difficult to breathe), talk to your doctor about what to do if you have an allergic reaction.

Stopping medication: The dose of nadolol should be gradually reduced, rather than stopped suddenly. There have been reports of severe worsening of angina, and of heart attack or abnormal heart rhythms occurring for people with angina pectoris who have stopped Nadolol without gradually reducing the dose. Discuss the risks and benefits of stopping nadolol with your doctor.

Surgery: If you are scheduled for surgery, inform all doctors involved in your care that you take nadolol. If it is planned surgery and it is necessary to stop taking nadolol before the surgery, it should be done gradually to reduce the risk of chest pain and increased blood pressure.

Pregnancy: Nadolol should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Nadolol, contact your doctor immediately.

Breast-feeding: Nadolol passes into breast milk. If you are a breast-feeding mother and are taking nadolol, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Nadolol have not been established for children.

Seniors: Seniors are at an increased risk of experiencing the side effects of nadolol. The starting dose and maximum daily dose may be lower for this population.

This medication is typically used only once a day. However, your pharmacist may have suggested a different schedule that is more appropriate for you. Important: Follow the instructions on the label. Do not use more of this product, or more often, than prescribed. It is not advisable to stop using this product suddenly, particularly if you have been on it for several weeks. If you are considering stopping the medication, talk to your pharmacist first. It must be used regularly and continuously to maintain its beneficial effects. Be sure to keep an adequate supply on hand. If you forget a dose, take it as soon as you remember -- unless it is almost time for your next dose. In that case, skip the missed dose. Do not double the next dose to catch up. This medication may be taken with or without food. To ensure effectiveness, avoid taking green tea or green tea supplements during treatment with this medication.