Matulane

Matulane (Procarbazine) is taken by mouth under medical supervision. The recommended dose and dosing schedule of Matulane (Procarbazine) varies according to body size. The dose is usually given for 14 days and is repeated every 4 weeks.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Matulane (Procarbazine) should only be prescribed by health care professionals familiar with the use of cancer chemotherapy.

It is important to use Matulane (Procarbazine) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

As well as interfering with the genetic material (DNA) of cancer cells, Matulane (Procarbazine) can interfere with some of your normal cells. This can cause a number of side effects. Keep track of any side effects and report them to your doctor as suggested in the section "What side effects are possible with Matulane (Procarbazine)?"

Store Matulane (Procarbazine) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

50 mg
Each No. 2 ivory gelatin capsule contains Matulane (Procarbazine) 50 mg (as Matulane (Procarbazine) HCl). Nonmedicinal ingredients: cornstarch, gelatin, mannitol, methylparaben, potassium sorbate, propylparaben, quinoline yellow WS, sunset yellow FCF, talc, and titanium dioxide.

Matulane (Procarbazine) should not be taken by anyone who:

• is allergic to Matulane (Procarbazine) or to any of the ingredients of the medication
• has severe depletion of neutrophils (white blood cells), platelets, or red blood cells

There may be an interaction between Matulane (Procarbazine) and any of the following:

• alcohol
• amphetamines (e.g., Dextroamphetamine, Lisdexamfetamine)
• antihistamines (e.g., Diphenhydramine, Chlorpheniramine)
• antipsychotics (e.g., Aripiprazole, Clozapine, Haloperidol, Risperidone)
• apraclonidine
• Atomoxetine
• atropine
• Baricitinib
• barbiturates (e.g., Phenobarbital, secobarbital)
• BCG
• beta-2 agonists (e.g., salbutamol, formoterol, terbutaline)
• beta-blockers (e.g., Acebutolol, Metoprolol, Propranolol)
• brimonidine
• Bromocriptine
• Buprenorphine
• Bupropion
• Buspirone
• calcium channel blockers (e.g., Amlodipine, Nifedipine)
• Carbamazepine
• Cyclobenzaprine
• Dextromethorphan
• Diabetes medications (e.g., chlorpropamide, Glyburide, insulin, Metformin, Rosiglitazone)
• Digoxin
• diphenoxylate
• Disopyramide
• disulfiram
• Domperidone
• echinacea
• Entacapone
• Epinephrine
• ergot alkaloids (e.g., ergotamine, Dihydroergotamine)
• Fingolimod
• guanethidine
• Lanreotide
• Leflunomide
• levodopa
• Linezolid
• lithium
• Methadone
• methyldopa
• Methylphenidate
• Metoclopramide
• mifepristone
• Mirtazapine
• monoamine oxidase inhibitors (M.O.S. e.g., methylene blue, Moclobemide, Rasagiline, Selegiline, Tranylcypromine)
• narcotic pain relievers (e.g., Codeine, Fentanyl, Morphine, Oxycodone)
• Natalizumab
• nefazodone
• Nivolumab
• norepinephrine
• Octreotide
• other cancer medications or radiation therapy
• other medications used to lower blood pressure (e.g., Furosemide, Hydralazine, Hydrochlorothiazide, Ramipril)
• Pasireotide
• pentamidine
• Pimecrolimus
• Pindolol
• Pseudoephedrine
• quinine
• Roflumilast
• St. John's wort
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, , Fluoxetine, Paroxetine, Sertraline)
• serotonin antagonists (anti-emetic medications; e.g., Granisetron, Ondansetron)
• serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., Desvenlafaxine, Duloxetine, Venlafaxine)
• Sunitinib
• Tacrolimus
• Tapentadol
• Tetrabenazine
• Tofacitinib
• tolcapone
• Tramadol
• Trastuzumab
• Trazodone
• tricyclic antidepressants (e.g., Amitriptyline, Clomipramine, Desipramine, Imipramine)
• "triptans" (e.g., Sumatriptan, Rizatriptan, Zolmitriptan)
• Tryptophan
• vaccines

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Matulane (Procarbazine). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Matulane (Procarbazine).

Alcohol: Avoid drinking alcohol while using Matulane (Procarbazine) and for a few days after stopping the medication. Drinking alcohol while using Matulane (Procarbazine) can lead to unpleasant symptoms such as nausea, flushing, racing heartbeat, and feelings of faintness. This reaction appears 5 to 10 minutes after drinking alcohol and can last from 30 minutes to several hours.

Blood clotting: Matulane (Procarbazine) can reduce the number of platelet cells in the blood. Platelets help the blood to clot, and a shortage could make you bleed more easily. Tell your doctor of any signs that your blood is not clotting as quickly as usual. Such symptoms may include black and tarry stools, blood in the urine, easy bruising, or cuts that won't stop bleeding. Your doctor will do blood tests regularly to monitor the number of platelets in your blood.

Damage to cells: Matulane (Procarbazine) can potentially cause other forms of cancer, such as Lung Cancer and acute myelocytic Leukemia (AML), when given in combination with other anticancer medications. The risk of developing lung cancer is increased with tobacco use. Birth defects and temporary or permanent fertility problems in both men and women may also occur. Permanent nerve damage has also occurred with Matulane (Procarbazine) use.

Dietary precautions: Severe reactions including sudden headache, flushed face, rapid, pounding heartbeat, nausea, vomiting, and dangerously high blood pressure may occur when foods with a high tyramine content are eaten while taking Matulane (Procarbazine). Examples of these foods include wine, yogurt, ripe C.E.S., and bananas. Ask your doctor or pharmacist for a list of foods that should be avoided.

Infection: As well as killing cancer cells, Matulane (Procarbazine) can reduce the number of cells that fight infection in the body (white blood cells). If possible, avoid contact with people who have contagious infections. Tell your doctor immediately if you begin to notice signs of an infection, such as fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness. Your doctor will do blood tests regularly to monitor the number of specific types of blood cells in your blood.

Kidney function: Matulane (Procarbazine) is removed from the body by the kidneys. If you have reduced kidney function, discuss with your doctor how Matulane (Procarbazine) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Matulane (Procarbazine), and whether any special monitoring is needed.

Liver function: Matulane (Procarbazine) is removed from the body by the liver. If you have reduced liver function, discuss with your doctor how Matulane (Procarbazine) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Matulane (Procarbazine), and whether any special monitoring is needed.

Pregnancy: There is a possibility of birth defects if either the father or mother is taking Matulane (Procarbazine) at the time of conception, or if it is taken during pregnancy. Matulane (Procarbazine) should not be used during pregnancy unless the benefits outweigh the risks. Use effective birth control while you are being treated with Matulane (Procarbazine). If you become pregnant while taking Matulane (Procarbazine), contact your doctor immediately.

Breast-feeding: It is not known if Matulane (Procarbazine) passes into breast milk. If you are a breast-feeding mother and are taking Matulane (Procarbazine), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Matulane (Procarbazine) have not been established for children. Children may be at an increased risk of side effects and must be monitored closely by the doctor.