Diflucan One

The recommended dose of fluconazole for vaginal Candidiasis (yeast) infections is a single 150 mg dose.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is very important that Diflucan One be taken as suggested by your doctor or pharmacist.

Store Diflucan One at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

In addition to its desired action, this medication may cause some adverse effects, notably: it may cause headaches; it may cause diarrhea; it may cause stomach ache; it may cause nausea and vomiting. Each person may react differently to a treatment. If you think this medication may be causing adverse effects (including those described here, or others), talk to your health care professional. He or she can help you to determine whether or not the medication is the source of the problem.

Each hard, white, gelatin capsule, marked with the Pfizer logo, contains 150 mg of fluconazole. Nonmedicinal ingredients: colloidal silicon dioxide, lactose, magnesium stearate, maize starch, and sodium lauryl sulfate; capsule shell: gelatin and titanium dioxide.

Do not take Diflucan One if you:

There may be an interaction between fluconazole and any of the following:

• alpha blockers (e.g., Alfuzosin, Doxazosin, Silodosin, Tamsulosin)
• amantadine
• amiodarone
• amphotericin B
• anti-cancer medications (e.g., Cabazitaxel, Docetaxel; Doxorubicin; Etoposide, Ifosfamide, Irinotecan, Vincristine)
• antihistamines (e.g., cetirizine, doxylamine, Diphenhydramine, Hydroxyzine, Loratadine)
• anti-psychotic medications (e.g., Clozapine, Quetiapine, Risperidone, Ziprasidone)
• anti-rejection medications (e.g., Pimecrolimus, Sirolimus, Tacrolimus)
• Apixaban
• Aprepitant
• asunaprevir
• other azole anti-fungals (e.g., ketoconazole, itraconazole, Voriconazole)
• benzodiazepines (e.g., Alprazolam, Chlordiazepoxide, Clonazepam, Clorazepate, Diazepam, Flurazepam, midazolam, Triazolam)
• birth control pills
• Bosentan
• Bromocriptine
• Buprenorphine
• Buspirone
• Calcitriol
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
• cannabis
• Carvedilol
• Celecoxib
• Cimetidine
• chloral hydrate
• chloroquine
• cisapride
• Clopidogrel
• Colchicine
• conivaptan
• corticosteroids (e.g., budesonide, Dexamethasone, Methylprednisolone, Prednisolone, Prednisone)
• Cyclosporine
• dabigatran
• Dapsone
• Degarelix
• didanosine
• Disopyramide
• dofetilide
• Domperidone
• Dronedarone
• Eliglustat
• Eplerenone
• estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
• Fingolimod
• Flutamide
• formoterol
• Galantamine
• Guanfacine
• HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delaviridine, efavirenz, etravirine, nevirapine)
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• Indapamide
• Ivabradine
• Ivacaftor
• lidocaine
• lithium
• Lomitapide
• Losartan
• macrolide antibiotics (e.g., clarithromycin, erythromycin)
• Maprotiline
• maraviroc
• Mefloquine
• Methadone
• mifepristone
• Moclobemide
• Mirtazapine
• Modafinil
• Montelukast
• Naloxegol
• narcotic pain relievers (e.g., Codeine, Fentanyl, Morphine, Oxycodone)
• nefazodone
• nitrates (e.g., isosorbide dinitrate, isosorbide mononitrate)
• Octreotide
• oxycodone
• pentamidine
• phosphodiesterase 5 inhibitors (e.g., Sildenafil, Tadalafil, Vardenafil)
• procainamide
• Propafenone
• praziquantel
• Primaquine
• progestins (e.g., Dienogest, Levonorgestrel, medroxyprogesterone, Norethindrone)
• proton pump inhibitors (e.g., Lansoprazole, Omeprazole)
• quinidine
• quinine
• quinolone antibiotics (e.g., ciprofloxacin, Ofloxacin, moxifloxacin)
• rifabutin
• rifampin
• rilpivirine
• Rivaroxaban
• Romidepsin
• salmeterol
• seizure medications (e.g., Carbamazepine, Gabapentin, Levetiracetam, Phenobarbital, Phenytoin, Topiramate)
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• serotonin antagonists (anti-emetic medications; e.g., Granisetron, Ondansetron)
• simeprevir
• Solifenacin
• Sotalol
• "statin" cholesterol medications (e.g., Atorvastatin, Lovastatin, Simvastatin)
• sulfonamide antibiotics (e.g., sulfadiazine, sulfamethoxazole, sulfisoxazole)
• sulfonylureas (e.g., glipizide, Glyburide)
• tacrolimus
• Tamoxifen
• Tetrabenazine
• Tetracycline
• theophyllines (e.g., Aminophylline, Oxtriphylline, Theophylline)
• Tolterodine
• Ticagrelor
• Ticlopidine
• Tolvaptan
• trabectedin
• Tramadol
• Trazodone
• tricyclic antidepressants (e.g., Amitriptyline, Imipramine, Nortriptyline)
• Trimethoprim
• tyrosine kinase inhibitors (e.g., Bosutinib, Dasatinib, imatinib, Nilotinib)
• Ulipristal
• Venlafaxine
• Warfarin
• Zafirlukast
• zidovudine
• Zolpidem
• Zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Diflucan One. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Diflucan One.

General: If this is your first yeast infection, if you have frequent yeast infections or heart disease, if you have another yeast infection within 2 months after taking Diflucan One, or if you have multiple sexual partners or change partners often, talk to your doctor or pharmacist before taking Diflucan One. Diflucan One should only be taken as a single dose.

The following symptoms are not caused by a yeast infection. Contact your doctor for treatment advice, if you experience them:

• abdominal pain
• discharge with a foul odour
• fever or chills
• lower back or shoulder pain
• nausea, vomiting, or diarrhea
• painful urination

If your symptoms have not improved in 3 days or disappeared in 7 days, contact your doctor.

Grapefruit juice: Taking fluconazole at the same time as drinking grapefruit juice may cause fluconazole to build up in the body and cause side effects. Avoid drinking grapefruit juice if you are taking Diflucan One.

Intercourse and birth control: Vaginal intercourse should be avoided when women have a yeast infection. This will help reduce the risk of infecting your sexual partner(s).

Diflucan One works in the body for several days after you take the dose. To avoid the risks of harm to the developing baby, if you are child-bearing age and may become pregnant, be sure to use an effective form of birth control for 7 days after taking Diflucan One.

QT prolongation: Diflucan One can cause changes in the electrical activity of the heart, called QT prolongation. If you have heart disease, abnormal electrolyte levels (e.g., potassium, sodium), or are taking other medications that can cause QT prolongation (e.g., quinidine, Amiodarone), discuss with your doctor how Diflucan One may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Diflucan One, and whether any special monitoring is needed.

Pregnancy: Diflucan One should not be used during pregnancy unless the benefits outweigh the risks. Women who take fluconazole for vaginal yeast infections and who may become pregnant should useadequate birth control for seven days after a dose of fluconazole.

Breast-feeding: Diflucan One passes into breast milk. If you are a breast-feeding mother and are taking fluconazole, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children and adolescents: The safety and effectiveness of fluconazole 150 mg capsules have not been established for the treatment of vaginal candidiasis in children under 12 years of age.

Generally, this medication is used as a single treatment. However, your pharmacist may have suggested a different schedule that is more appropriate for you. Important: Follow the instructions on the label. Do not use more of this product, or more often, than prescribed. This medication may be taken with or without food. Avoid consuming alcohol or alcohol-containing products while taking this medication.