Nozinan

The dose of Nozinan (Methotrimeprazine) varies widely depending on the condition being treated and the circumstances and age of the person being treated.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Nozinan (Methotrimeprazine) exactly as prescribed by your doctor. If you miss a dose, contact your doctor or pharmacist for advice. Do not take a double dose to make up for a missed one.

Store Nozinan (Methotrimeprazine) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

In addition to its desired action, this medication may cause some adverse effects, notably: it may cause dryness of the mouth; it may make your skin more sensitive to UV rays (e.g., sunlight, tanning lamps) - avoid exposure to UV rays as much as possible and protect yourself when out in the sun; it may cause weight gain, mostly with prolonged use; it may cause drowsiness that lasts until the next day - use caution until you know how you will react; it may increase your heart rate; it may lower your blood pressure, which could cause weakness and/or dizziness - use caution when getting up from a lying or sitting position and when driving. Each person may react differently to a treatment. If you think this medication may be causing adverse effects (including those described here, or others), talk to your health care professional. He or she can help you to determine whether or not the medication is the source of the problem.

Each mL contains Nozinan (Methotrimeprazine) base 25 mg (as the hydrochloride). Nonmedicinal ingredients: ascorbic acid, sodium chloride, sodium sulfite, and water for injection.

Do not take Nozinan (Methotrimeprazine) if you:

• are allergic to Nozinan (Methotrimeprazine), or any ingredient of Nozinan (Methotrimeprazine)
• are allergic to other phenothiazines (e.g., Chlorpromazine)
• are excessively sedated by alcohol, sleeping pills, tranquilizers, pain relievers, or narcotics
• have a blood disorder
• have liver problems
• have brain damage
• have pheochromocytoma (a tumour in the adrenal glands)
• are being treated with regional or spinal pain relief (epidural infusion)
• are experiencing severely Low Blood Pressure or severe heart disorder

There may be an interaction between Nozinan (Methotrimeprazine) and any of the following:

• aclidinium
• alcohol
• Alfuzosin
• Amiodarone
• antacids (e.g., aluminum hydroxide, magnesium hydroxide)
• antihistamines (e.g., cetirizine, doxylamine, Diphenhydramine, Hydroxyzine, Loratadine)
• anti-malarial medications (e.g., chloroquine, hydroxychloroquine, Primaquine)
• anti-Parkinsons medications (e.g., amantadine, Apomorphine, Bromocriptine, levodopa, Pramipexole, Ropinirole)
• antipsychotics (e.g., chlorpromazine, Clozapine, Haloperidol, Olanzapine, Quetiapine, Risperidone)
• amphetamines (e.g., Dextroamphetamine, Lisdexamfetamine)
• Atomoxetine
• atropine
• azelastine
• barbiturates (e.g., butalbital, Phenobarbital)
• belladonna
• benzodiazepines (e.g., Alprazolam, Diazepam, Lorazepam)
• benztropine
• beta-adrenergic blockers (e.g., Metoprolol, Propranolol, sotalol)
• botulinum toxin
• brimonidine
• bromocriptine
• Bupropion
• Buspirone
• cannabis
• chloral hydrate
• Darifenacin
• Degarelix
• Dextromethorphan
• diabetes medications (e.g., chlorpropamide, glipizide, Glyburide, insulin, Metformin, Rosiglitazone)
• Disopyramide
• dofetilide
• Domperidone
• Donepezil
• Dronedarone
• efavirenz
• ergot alkaloids (e.g., ergotamine, Dihydroergotamine)
• Flavoxate
• Flecainide
• Galantamine
• general anesthetics (medications used to put people to sleep before surgery)
• Glucagon
• glycopyrrolate
• guanethidine
• ipratropium
• lithium
• lopinavir
• macrolide antibiotics (e.g., clarithromycin, erythromycin)
• Methadone
• Methylphenidate
• Metoclopramide
• Mexiletine
• mifepristone
• Mirabegron
• Mirtazapine
• monoamine oxidase inhibitors (M.O.S. e.g., Moclobemide, Rasagiline, Selegiline, Tranylcypromine)
• muscle relaxants (e.g., Baclofen, Cyclobenzaprine, methocarbamol, orphenadrine, Tizanidine)
• Nabilone
• narcotic pain relievers (e.g., Codeine, Fentanyl, Morphine, Oxycodone)
• nefazodone
• Nitroglycerin
• Olopatadine
• oxybutynin
• Porfimer
• Pregabalin
• procainamide
• Propafenone
• Pseudoephedrine
• quinidine
• quinine
• quinolone antibiotics (e.g., ciprofloxacin, Norfloxacin, Ofloxacin)
• rilpivirine
• Rivastigmine
• St. John's wort
• saquinavir
• seizure medications (e.g., Clobazam, Levetiracetam, phenobarbital, Phenytoin, primidone, Topiramate, Valproic acid, zonisamide)
• serotonin antagonists (anti-emetic medications; e.g., Granisetron, Ondansetron)
• serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., Desvenlafaxine, Duloxetine, Venlafaxine)
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• sodium oxybate
• sotalol
• Tamoxifen
• Tamsulosin
• Tetrabenazine
• thalidomide
• thiazide diuretics (water pills; e.g., Hydrochlorothiazide, Indapamide, Metolazone)
• tiotropium
• Tolterodine
• Tramadol
• Trazodone
• tricyclic antidepressants (e.g., Amitriptyline, Clomipramine, Desipramine, Trimipramine)
• "triptan" migraine medications (e.g., Eletriptan, Sumatriptan)
• Tryptophan
• certain tyrosine kinase inhibitors (e.g., Lapatinib, Pazopanib, Sunitinib)
• umeclidinium
• Voriconazole
• Zopiclone
• Zolpidem

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Nozinan (Methotrimeprazine). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Nozinan (Methotrimeprazine).

Abnormal heart rhythms: Nozinan (Methotrimeprazine) can cause abnormal heart rhythms. Certain medications (e.g., Sotalol, quinidine, thioridazine, chlorpromazine, droperidol, Pimozide, moxifloxacin, Mefloquine, pentamidine, arsenic trioxide, probucol, Tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should not be used in combination with Nozinan (Methotrimeprazine). You are more at risk for this type of abnormal heart rhythm and its complications if you:

• are female
• are older than 65 years of age
• have a family history of sudden cardiac death
• have a history of heart disease or abnormal heart rhythms
• have a slow heart rate
• have congenital prolongation of the QT interval
• have Diabetes
• have had a Stroke
• have low potassium, magnesium, or calcium levels
• have nutritional deficiencies

If you have heart disease and abnormal heart rhythms, or are taking certain medications (e.g., Verapamil, atazanavir), discuss with your doctor how Nozinan (Methotrimeprazine) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nozinan (Methotrimeprazine), and whether any special monitoring is needed.

Blood Clots: Rarely, Nozinan (Methotrimeprazine) may increase the chance of blood clot formation, causing reduction of blood flow to organs or the extremities. If you have a history of clotting you may be at increased risk of experiencing blood clot-related problems such as Heart Attack, stroke, or clots in the deep veins of your leg. Discuss with your doctor how Nozinan (Methotrimeprazine) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nozinan (Methotrimeprazine), and whether any special monitoring is needed.

If you experience symptoms such as sharp pain and swelling in the leg, difficulty breathing, chest pain, blurred vision, or difficulty speaking, contact your doctor immediately.

Body temperature: Nozinan (Methotrimeprazine), like other antipsychotic medications, may interfere with your body's ability to regulate body temperature. People who exercise vigorously, who are exposed to extreme heat, are dehydrated, or are taking anticholinergic medications (e.g., Benztropine, Oxybutynin) are more at risk. Contact your doctor as soon as possible if you feel very hot and are unable to cool.

Take care to avoid overheating during strenuous exercise or in hot temperatures, and avoid becoming dehydrated by drinking enough fluids.

Diabetes: Nozinan (Methotrimeprazine) may increase blood sugar for people with diabetes or those who are at risk for diabetes. If you have diabetes, monitor your blood sugar frequently as recommended by your doctor. If you experience symptoms of high blood sugar (e.g., increased urination, increased thirst, increased eating, and weakness) while taking Nozinan (Methotrimeprazine), contact your doctor.

Dizziness/lightheadedness: In high doses, dizziness or lightheadedness when getting up from a sitting or lying position may be experienced at the start of treatment. To reduce the possibility of experiencing this, rise slowly from a sitting or lying position.

Drowsiness/reduced alertness: Nozinan (Methotrimeprazine) can cause drowsiness and reduced alertness, especially during the first few days of treatment. Avoid driving, operating machinery, or performing other tasks that require mental alertness until you have determined how Nozinan (Methotrimeprazine) affects you.

Glaucoma: Nozinan (Methotrimeprazine) may cause the symptoms of glaucoma (increased pressure in the eye) to become worse. If you have glaucoma, discuss with your doctor how Nozinan (Methotrimeprazine) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nozinan (Methotrimeprazine), and whether any special monitoring is needed. Report any changes in vision to your doctor as soon as possible while you are taking Nozinan (Methotrimeprazine).

Neuroleptic malignant syndrome (NMS): Nozinan (Methotrimeprazine) may cause a potentially fatal reaction called neuroleptic malignant syndrome (NMS). If you develop symptoms of NMS, such as muscle stiffness, fever, confusion, sweating, or irregular heartbeat, stop taking Nozinan (Methotrimeprazine) and seek immediate medical attention.

Tardive dyskinesia: People taking Nozinan (Methotrimeprazine) may develop tardive dyskinesia, a syndrome of uncontrolled body movements. This syndrome may be irreversible. If you develop uncontrolled or unusual body movements, contact your doctor as soon as possible.

Urinary tract problems: Nozinan (Methotrimeprazine) can cause the symptoms of some urinary tract problems to become worse. If you have an enlarged prostate or another condition that causes urination to be difficult, discuss with your doctor how Nozinan (Methotrimeprazine) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nozinan (Methotrimeprazine), and whether any special monitoring is needed.

Pregnancy: Nozinan (Methotrimeprazine) should not be used during pregnancy unless the benefits outweigh the risks. Infants born to mothers who used Nozinan (Methotrimeprazine) in the later part of pregnancy have had abnormal muscle movement and withdrawal symptoms, including decreased muscle tone, sleepiness, difficulty feeding and severe difficulty breathing after birth. These symptoms can be severe and need medical attention. If you become pregnant while taking Nozinan (Methotrimeprazine), contact your doctor immediately.

Breast-feeding: Nozinan (Methotrimeprazine) passes into breast milk. If you are a breast-feeding mother and are taking Nozinan (Methotrimeprazine), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Seniors: Seniors with Dementia who take Nozinan (Methotrimeprazine) may be at an increased risk of death due either heart disease or infections compared to seniors who are not taking Nozinan (Methotrimeprazine). The use of Nozinan (Methotrimeprazine) by older adults is not recommended.

This medication is typically used only once a day. However, your pharmacist may have suggested a different schedule that is more appropriate for you. Take it regularly and continuously to maintain its beneficial effects. Important: Follow the instructions on the label. Do not use more of this product, or more often, than prescribed. It is not advisable to stop using this product suddenly, particularly if you have been on it for several weeks. If you are considering stopping the medication, talk to your pharmacist first. This medication may irritate the stomach, and should be taken with food. It is best to avoid coffee, spicy food or alcohol. Consuming alcohol may intensify the effect of this product. It is therefore advisable to avoid consuming alcohol or alcohol-containing products while taking this medication.