Apo Clarithromycine Xl

Adults: The recommended adult dose of clarithromycin tablets is 250 mg to 500 mg twice daily (every 12 hours) for 7 to 14 days, depending on the condition being treated.

The recommended adult dose of the extended-release form of clarithromycin is 1,000 mg (2 tablets) once daily for 5 to 14 days, depending on the condition being treated.

For the treatment and prevention of MAC, the usual dose of clarithromycin is 500 mg twice daily. When used with other medications to kill H. pylori, the usual dose of clarithromycin is 500 mg twice daily for 10 days.

Children: The recommended total daily dose for children is 15 mg per kilogram of body weight (to a maximum of 1,000 mg per day). This total daily dose should be divided in 2 equal doses given 12 hours apart. Total treatment duration is usually 5 to 10 days, depending on the condition being treated. For the treatment and prevention of MAC, the usual dose of clarithromycin is 7.5 mg per kilogram of body weight twice daily (up to 500 mg twice daily).

If the child is receiving an oral suspension of clarithromycin, use an oral syringe to measure each dose of the liquid, as it gives a more accurate measurement than household teaspoons.

Clarithromycin tablets and clarithromycin suspension (given twice daily) may be taken with or without food. Taking Apo Clarithromycine Xl with food may cause less stomach upset.

The extended-release tablets of clarithromycin must be taken with food. The tablets must be swallowed whole and not crushed or broken.

Finish all of Apo Clarithromycine Xl, even if you have started to feel better.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Apo Clarithromycine Xl exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store clarithromycin tablets at room temperature, protect them from light and moisture, and keep them out of the reach of children.

Store clarithromycin oral suspension at room temperature with the bottle tightly closed and protected from light. Do not refrigerate. Any unused oral suspension should be thrown away after 14 days. Rinse the dose-measuring oral syringe between uses. Do not store the suspension in the syringe.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

In addition to its desired action, this medication may cause some adverse effects, notably: it may cause headaches; it may cause diarrhea; it may cause stomach ache; it may alter your sense of taste; it may cause nausea and vomiting. Each person may react differently to a treatment. If you think this medication may be causing adverse effects (including those described here, or others), talk to your health care professional. He or she can help you to determine whether or not the medication is the source of the problem.

250 mg
Each yellow, oval, biconvex, film-coated tablet, engraved "APO" on one side and plain on the other side, contains 250 mg of clarithromycin. Nonmedicinal ingredients: colloidal silicon dioxide, crospovidone, D&C Yellow No. 10, hydroxyethyl cellulose, magnesium stearate, polyethylene glycol, stearic acid, sunset yellow, and titanium dioxide.

500 mg
Each light yellow, capsule-shaped, biconvex, film-coated tablet, engraved "APO" on one side and plain on the other side, contains 500 mg of clarithromycin. Nonmedicinal ingredients: colloidal silicon dioxide, crospovidone, D&C Yellow No. 10, hydroxyethyl cellulose, magnesium stearate, polyethylene glycol, stearic acid, and titanium dioxide.

Apo-Clarithromycin XL

Each light yellow, oval, biconvex, coated tablet, engraved "APO" on one side and "CXL500" on the other, contains 500 mg of clarithromycin. Nonmedicinal ingredients: hydroxyethyl cellulose, magnesium stearate, polyethylene glycol, potassium bitartrate, sorbitol, titanium dioxide, and D & C Yellow No. 10.

Do not take clarithromycin if you:

• are allergic to clarithromycin or any ingredients of Apo Clarithromycine Xl
• are allergic to other macrolide antibiotics, such as erythromycin or azithromycin
• have had jaundice (yellowing of the skin or eyes) or liver problems associated with taking clarithromycin
• have severe liver failure in addition to decreased kidney function
• have or have had QT prolongation (an abnormal electrical activity of the heart) or an abnormal heart rhythm
• have untreated hypokalemia (low potassium levels in the blood)
• are taking any of the following medications:
  • astemizole
  • cisapride
  • Colchicine
  • Domperidone
  • ergot alkaloids (e.g., Dihydroergotamine, ergonovine, ergotamine, methylergonovine)
  • oral midazolam
  • Pimozide
  • saquinavir
  • "statin" cholesterol lowering medications (e.g., Lovastatin, Simvastatin)
  • terfenadine
  • Ticagrelor

There may be an interaction between clarithromycin and any of the following:

• Abiraterone acetate
• Aliskiren
• Almotriptan
• alpha-blockers (e.g., Alfuzosin, Doxazosin, Silodosin, Tamsulosin)
• amiodarone
• anti-cancer medications (e.g., Cabazitaxel, Docetaxel, Doxorubicin, Etoposide, Ifosfamide, Irinotecan, Vincristine)
• anti-emetic medications (serotonin antagonists; e.g., Granisetron, Ondansetron)
• antihistamines (e.g., cetirizine, doxylamine, Diphenhydramine, Hydroxyzine, Loratadine)
• antipsychotics (e.g., Chlorpromazine, Clozapine, Haloperidol, Olanzapine, Quetiapine, Risperidone)
• Apalutamide
• Apixaban
• Aprepitant
• "azole" antifungals (e.g., itraconazole, ketoconazole, Voriconazole)
• bacillus Calmette-Guérin (BCG) vaccine
• benzodiazepines (e.g., Clonazepam, Diazepam, Lorazepam)
• Bicalutamide
• Bosentan
• Brinzolamide
• Bromocriptine
• Buprenorphine
• Buspirone
• Cabergoline
• Calcitriol
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
• cannabis
• Carbamazepine
• Carvedilol
• chloroquine
• Cholera vaccine
• Cimetidine
• Cinacalcet
• Clopidogrel
• Cobicistat
• colchicine
• conivaptan
• corticosteroids (e.g., Dexamethasone, Hydrocortisone, Prednisone)
• Cyclosporine
• dabigatran
• Dantrolene
• Darifenacin
• Deferasirox
• Degarelix
• Digoxin
• Disopyramide
• Divalproex
• dofetilide
• domperidone
• Donepezil
• Dronedarone
• Dutasteride
• Edoxaban
• Eletriptan
• Enzalutamide
• Eplerenone
• ergot alkaloids (e.g., dihydroergotamine, ergonovine, ergotamine, methylergonovine)
• estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol, Norethindrone)
• Ethosuximide
• Everolimus
• Fingolimod
• Flecainide
• Fentanyl
• formoterol
• Galantamine
• "gliptin" Diabetes medications (e.g., Linagliptin, Saxagliptin, Sitagliptin)
• grapefruit juice
• Guanfacine
• Hepatitis C antivirals (e.g., asunaprevir, daclatasvir, grazoprevir)
• HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, etravirine, nevirapine)
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• Indacaterol
• insulin
• ivermectin
• lidocaine
• lithium
• Lomitapide
• Loperamide
• Macitentan
• other macrolide antibiotics (e.g., azithromycin, erythromycin)
• maraviroc
• medications used to treat diabetes (e.g., Pioglitazone, Rosiglitazone, Repaglinide)
• Mefloquine
• Methadone
• mifepristone
• Mirtazapine
• Modafinil
• Nadolol
• narcotic pain relievers (e.g., Codeine, fentanyl, Morphine, Oxycodone)
• nefazodone
• nitrates (e.g., isosorbide dinitrate, isosorbide mononitrate)
• Oxybutynin
• pentamidine
• Phenobarbital
• Phenytoin
• phosphodiesterase 5 inhibitors (e.g., Sildenafil, Tadalafil, Vardenafil)
• Prasugrel
• praziquantel
• primidone
• procainamide
• progestins (e.g., Dienogest, Levonorgestrel, medroxyprogesterone, norethindrone)
• Propafenone
• proton pump inhibitors (e.g., Lansoprazole, Omeprazole)
• quinidine
• quinine
• quinolone antibiotics (e.g., ciprofloxacin, Norfloxacin, Ofloxacin)
• Ranitidine
• rifabutin
• rifampin
• rifaximin
• rilpivirine
• Rivaroxaban
• Romidepsin
• salmeterol
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• serotonin-norepinephrine reuptake inhibitors (SNRIs; e.g., Duloxetine, Venlafaxine)
• Sirolimus
• sodium picosulfate
• sotalol
• "statin" anti-cholesterol medications (e.g., Atorvastatin, lovastatin, simvastatin)
• St. John's wort
• sulfonylureas (e.g., Glyburide, Tolbutamide)
• Tacrolimus
• Tamoxifen
• theophyllines (e.g., Aminophylline, Oxtriphylline, Theophylline)
• ticagrelor
• Tofacitinib
• Tolterodine
• Tolvaptan
• Tramadol
• Trazodone
• tricyclic antidepressants (e.g., Amitriptyline, Clomipramine, Desipramine, Trimipramine)
• Trimethoprim
• typhoid vaccine
• tyrosine kinase inhibitors (e.g., Dasatinib, imatinib, Nilotinib)
• Ulipristal
• Valproic acid
• vilanterol
• Warfarin
• zidovudine
• Zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than the ones listed above may interact with Apo Clarithromycine Xl. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Apo Clarithromycine Xl.

Abnormal heart rhythm: Clarithromycin may cause a heart rhythm problem called QT prolongation. If you have a history of QT prolongation, a medical condition associated with QT prolongation, or are taking certain medications (e.g., Amiodarone, Sotalol), discuss with your doctor how Apo Clarithromycine Xl may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Clarithromycine Xl, and whether any special monitoring is needed.

Allergy: If you have had some form of allergy to erythromycin or azithromycin, you may be more likely to have an allergic reaction to Apo Clarithromycine Xl. If you develop symptoms of an allergic reaction such as a rash, contact your doctor. If you develop hives; difficulty breathing; or swelling of the face, mouth, throat, or tongue, stop taking Apo Clarithromycine Xl and get immediate medical attention.

Bacterial resistance: Misuse of an antibiotic such as clarithromycin may lead to the growth of resistant bacteria that will not be killed by the antibiotic. If this happens, the antibiotic may not work for you in the future. Although you may begin to feel better when you first start taking clarithromycin, you need to take all of the medication, exactly as prescribed by your doctor, to finish ridding your body of the infection and to prevent resistant bacteria from taking hold. Do not take clarithromycin or other antibiotics to treat a viral infection such as The Common Cold; antibiotics do not kill viruses, and using them to treat viral infections can lead to the growth of resistant bacteria.

Diarrhea: As with other antibiotics, clarithromycin is associated with a serious infection called Clostridium difficile-associated diarrhea, caused by the bacteria C. difficile. This can occur as late as 2 months after your last dose of Apo Clarithromycine Xl.

If you have loose, watery bowel movements especially if they are green, foul-smelling, or bloody and accompanied by Fever, either during or after taking clarithromycin, get medical attention as soon as possible.

Dizziness, confusion, and disorientation: Apo Clarithromycine Xl can cause dizziness, confusion, or disorientation. Do not drive or operate machinery until you are certain that Apo Clarithromycine Xl does not affect your ability to perform these tasks safely.

Kidney function: Kidney Disease or reduced kidney function may cause Apo Clarithromycine Xl to build up in the body, causing side effects. If you have reduced kidney function, discuss with your doctor how Apo Clarithromycine Xl may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Clarithromycine Xl, and whether any special monitoring is needed.

Liver problems: Liver disease or reduced liver function may cause Apo Clarithromycine Xl to build up in the body, causing side effects. If you have reduced liver function, discuss with your doctor how Apo Clarithromycine Xl may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Clarithromycine Xl, and whether any special monitoring is needed. Apo Clarithromycine Xl should not be used by people with severe liver problems.

If you develop symptoms of liver problems (e.g., loss of appetite, nausea, vomiting, yellowing of the skin or eyes, dark urine, itchy skin, abdominal pain), contact your doctor immediately.

Myasthenia gravis: Apo Clarithromycine Xl can worsen or cause symptoms of myasthenia gravis. If your symptoms worsen or you develop new symptoms such as double vision, drooping eyelids, muscle weakness, or difficulty chewing or swallowing, contact your doctor.

Pregnancy: Clarithromycin should not be used during pregnancy, especially the first 3 months of pregnancy, unless there is no other appropriate therapy. If you become pregnant while taking Apo Clarithromycine Xl, contact your doctor.

Breast-feeding: Apo Clarithromycine Xl passes into breast milk. If you are a breast-feeding mother and are taking clarithromycin, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using clarithromycin oral suspension have not been established for children younger than 6 months old. For pneumonia, the use of clarithromycin oral suspension has not been studied for children younger than 3 years old. The safety and effectiveness of using clarithromycin to prevent MAC infection has not been studied for children younger than 20 months old. The safety and effectiveness of using clarithromycin tablets have not been established for children younger than 12 years old.

<p>Clarithromycin belongs to the group of medications called <i>macrolide antibiotics.</i> It is used to <b>treat infections caused by certain bacteria.</b> It works by killing or stopping the growth of bacteria that can cause certain infections. Clarithromycin may be prescribed for people with bacterial throat infections, sinus infections, ear infections, Bronchitis, pneumonia, and skin infections such as impetigo and Cellulitis.</p><p>Clarithromycin may also be used to prevent and treat certain infections (<i>mycobacterium avium complex </i>or MAC), associated with human immunodeficiency virus (HIV) infection. Clarithromycin can be used in combination with other medications to kill <i>H. pylori,</i> a bacteria known to cause ulcers in the digestive tract.</p><p><b>Apo Clarithromycine Xl may be available under multiple brand names and/or in several different forms.</b> Any specific brand name of Apo Clarithromycine Xl may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Apo Clarithromycine Xl may not be used for all of the conditions discussed here.</p><p><b>Your doctor may have suggested Apo Clarithromycine Xl for conditions other than those listed in these drug information articles.</b> If you have not discussed this with your doctor or are not sure why you are taking Apo Clarithromycine Xl, speak to your doctor. <b>Do not stop taking Apo Clarithromycine Xl without consulting your doctor.</b></p><p><b>Do not give Apo Clarithromycine Xl to anyone else, even if they have the same symptoms as you do.</b> It can be harmful for people to take Apo Clarithromycine Xl if their doctor has not prescribed it.</p>