Moclobemide

The usual starting dose of moclobemide for adults is 150 mg twice daily. If necessary, your doctor may gradually increase your dose after the first week to a maximum of 300 mg twice daily. The recommended dose of moclobemide for adults ranges from 150 mg to 300 mg, taken twice daily after meals.

Moclobemide should be swallowed whole with a glass of water. Do not split, crush, chew, or dissolve the tablets.

Moclobemide may take a few days to several weeks to achieve the best effect. Unlike other MAO inhibitors, no special dietary restrictions are necessary when taking moclobemide. It is very important, however, to always take Moclobemide immediately after you have eaten.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Moclobemide exactly as prescribed by your doctor. Do not stop taking Moclobemide without talking to your doctor first, even if you start to feel better. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Moclobemide at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

In addition to its desired action, this medication may cause some adverse effects, notably: it may cause dryness of the mouth; it may cause headaches; it may cause dizziness - use caution when getting up from a lying or sitting position and use caution if driving; it may cause sleep disturbances or insomnia; it may cause nausea or, rarely, vomiting; it may cause shakiness. Each person may react differently to a treatment. If you think this medication may be causing adverse effects (including those described here, or others), talk to your health care professional. He or she can help you to determine whether or not the medication is the source of the problem.

100 mg
Each oval-shaped, scored, orange, film-coated tablet contains 100 mg of moclobemide. Nonmedicinal ingredients: dextrates, croscarmellose sodium, magnesium stearate, colloidal silicon dioxide, hydroxypropyl methylcellulose 2910 ES, polydextrose, polyethylene glycol 33580, titanium dioxide, yellow ferric oxide, red ferric oxide, and carnauba wax.

150 mg
Each oval-shaped, scored, pale yellow, film-coated tablet contains 150 mg of moclobemide. Nonmedicinal ingredients: dextrates, croscarmellose sodium, magnesium stearate, colloidal silicon dioxide, hydroxypropyl methylcellulose 2910 ES, polydextrose, Polyethylene Glycol 3350, titanium dioxide, yellow ferric oxide, and carnauba wax.

300 mg
Each oval-shaped, scored, white, film-coated tablet contains 300 mg of moclobemide. Nonmedicinal ingredients: methylcellulose 15 CPS, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, colloidal silicon dioxide, hydroxypropyl cellulose type LF, hydroxypropyl methylcellulose 2910 ES, polyethylene glycol 8000 and titanium dioxide.

Do not take Moclobemide if you:

• are allergic to moclobemide or any ingredients of the medication
• are in an acute state of confusion
• are taking any of the following medications:
  • Bupropion
  • Dextromethorphan
  • Meperidine
  • other MAO inhibitors e.g., Tranylcypromine)
  • Selegiline
  • SNRI antidepressants e.g., Desvenlafaxine)
  • SSRI antidepressants e.g., Fluoxetine, Sertraline)
  • thioridazine
  • Tramadol
  • tricyclic antidepressants (e.g., Amitriptyline)
  • "triptan" migraine medications (e.g., Sumatriptan)

There may be an interaction between moclobemide and any of the following:

• alcohol
• acetylcholinesterase inhibitors (e.g., Donepezil, Galantamine, Rivastigmine)
• aclidinium
• alpha/beta agonists (e.g., Epinephrine, norepinephrine)
• alpha agonists (e.g., Clonidine, methyldopa)
• amphetamines (e.g., Dextroamphetamine)
• anesthetics (e.g., halothane)
• anti-emetic medications (e.g., Granisetron, Ondansetron)
• antihistamines (e.g,. cetirizine, doxylamine, Diphenhydramine, Hydroxyzine, Loratadine)
• antipsychotic medications (e.g., Haloperidol, Quetiapine, Risperidone)
• appetite suppressants (e.g., sibutramine, mazindol)
• Atomoxetine
• atropine
• azelastine
• "azole" antifungals (e.g., itraconazole, ketoconazole, Voriconazole)
• belladonna
• Benztropine
• beta-2 agonists (e.g., salbutamol, formoterol, terbutaline)
• Betahistine
• Bezafibrate
• botulinum toxin
• Bromocriptine
• bupropion
• Buspirone
• Cabergoline
• Carbamazepine
• Cimetidine
• clidinium
• Clobazam
• Clopidogrel
• Cyclobenzaprine
• decongestants (e.g., phenylephrine, oxymetazoline, Pseudoephedrine, tetrahydrazoline, xylometazoline)
• Dabrafenib
• delavirdine
• dextromethorphan
• Diabetes medications (e.g., chlorpropamide, glipizide, Glyburide, insulin, Metformin, Nateglinide, Rosiglitazone)
• Diazepam
• Disopyramide
• Domperidone
• efavirenz
• Entacapone
• Enzalutamide
• ergot alkaloids (e.g., ergotamine, Dihydroergotamine)
• Esomeprazole
• Fesoterodine
• Flavoxate
• Gemfibrozil
• glaucoma medications (e.g., apraclonidine, brimonidine)
• isoniazid
• Glucagon
• glycopyrrolate
• ipratropium
• isoniazid
• ketotifen
• levodopa
• lithium
• Linezolid
• lopinavir
• Maprotiline
• meperidine
• methylene blue
• Methylphenidate
• Metoclopramide
• Midodrine
• Mirabegron
• Mirtazapine
• Modafinil
• other monoamine oxidase inhibitors (M.O.S. e.g., moclobemide, phenelzine, Rasagiline, selegiline, tranylcypromine)
• narcotic medications (e.g., Fentanyl, Morphine, Codeine, Oxycodone)
• nefazodone
• Octreotide
• Omeprazole
• orphenadrine
• Oxybutynin
• Phenobarbital
• Phenytoin
• Pizotifen
• potassium chloride
• quinidine
• quinine
• reserpine
• rifampin
• St. John's wort
• scopolamine
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, fluoxetine, Paroxetine, sertraline)
• serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., desvenlafaxine, Duloxetine, Venlafaxine)
• Solifenacin
• Stiripentol
• sympathomimetic medications (e.g., epinephrine, norepinephrine)
• Tapentadol
• Tetrabenazine
• tetrahydrozoline
• thioridazine
• tiotropium
• Ticlopidine
• Tizanidine
• Tolterodine
• tramadol
• Trazodone
• tricyclic antidepressants (e.g., amitriptyline, Clomipramine, Desipramine)
• "triptan" migraine medications (e.g., Rizatriptan, sumatriptan)
• Trospium
• Tryptophan
• umeclidinium

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Moclobemide. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Moclobemide.

Diet restrictions: Treatment with moclobemide does not require special diet restrictions as with other MAO inhibitors such as Phenelzine. However, you should avoid consuming large amounts of certain foods, such as over 70 g of Marmite or 200 g of strong C.E.S.. As a safety measure, immediately report the sudden occurrence of any of the following:

• extremely fast or slow heart rate
• headache
• neck stiffness
• other unusual symptoms not previously experienced
• palpitations

Drowsiness/reduced alertness: Moclobemide may cause drowsiness or dizziness. Do not drive, operate machinery, or perform other potentially hazardous tasks until you have determined how Moclobemide affects you.

Glaucoma: Moclobemide may cause symptoms of glaucoma (increased pressure in the eyes), such as blurred vision or eye pain or pressure, to become worse. If you have glaucoma, discuss with your doctor how Moclobemide may affect your medical condition, and whether any special monitoring is needed.

Kidney Disease: If you have reduced kidney function or kidney disease, discuss with your doctor how Moclobemide may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Moclobemide, and whether any special monitoring is needed.

Liver function: Liver disease or reduced liver function may cause Moclobemide to build up in the body, causing side effects. If you have reduced liver function or liver disease, discuss with your doctor how Moclobemide may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Moclobemide, and whether any special monitoring is needed. For people with severe liver dysfunction, the daily dose of moclobemide should be reduced to one-third or one-half of the standard dose.

Other medications: Treatment with tricyclic antidepressants may be started after moclobemide has been stopped for at least 2 days. Do not start treatment with moclobemide until antidepressants have been stopped for 2 weeks in most cases (wait 5 weeks after taking fluoxetine).

Suicidal or agitated behaviour: People taking Moclobemide may feel agitated (restless, anxious, aggressive, emotional, and feeling not like themselves), or they may want to hurt themselves or others. These symptoms may occur within several weeks after starting Moclobemide. If you experience these side effects or notice them in a family member who is taking Moclobemide, contact your doctor immediately. You should be closely monitored by your doctor for emotional and behaviour changes while taking Moclobemide.

Thyroid disease: With certain types of thyroid disease, Moclobemide can cause a severe increase in blood pressure. If you have thyroid disease, discuss with your doctor how Moclobemide may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Moclobemide, and whether any special monitoring is needed.

Pregnancy: The safety of using moclobemide during pregnancy has not been established. Moclobemide should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Moclobemide, contact your doctor immediately.

Breast-feeding: Moclobemide passes into breast milk. If you are a breast-feeding mother and are taking moclobemide, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Moclobemide have not been established for children.

This medication is typically used twice a day. However, your pharmacist may have suggested a different schedule that is more appropriate for you. Important: Follow the instructions on the label. Do not use more of this product, or more often, than prescribed. It is not advisable to stop using this product suddenly, particularly if you have been on it for several weeks. If you are considering stopping the medication, talk to your pharmacist first. It must be used regularly and continuously to maintain its beneficial effects. Be sure to keep an adequate supply on hand. If you forget a dose, take it as soon as you remember -- unless it is almost time for your next dose. In that case, skip the missed dose. Do not double the next dose to catch up. This medication should be taken immediately after finishing a meal. Consuming alcohol may intensify the effect of this product. If you choose to drink alcohol, do so in moderation. Talk to your health care professional to find out exactly how much alcohol you can drink. A severe reaction may occur if this medication is taken with certain foods, such as: fermented cheese, cold cuts, beer, shrimp, organ meats and red wine. Avoid these foods during your treatment.